有毒性的

It was decided at this meeting that the investigation of gelatin and oxypolygelatin should be discontinued until a product could be supplied that could be characterized physicochemically; with evidence of reproducibility and stability; and of higher molecular size, so that it would not be excreted at an excessive rate, as were the products then in use.

在这次会议上决定了，直到一个产品可以提供理化兼备的特点，有再现性和稳定性的特征，和较高的分子量以使它不能以过高的速率排出，直到将来这样产品被应用，明胶和氧化聚明胶的研究才能中断，在动物身上的忍受性和毒性也应该很理想。

Susan D. Horn, Harold L. Wright, James J. Couperus, Robert S. Rhodes, Randall J. Smout, Kevin A. Roberts, Antonio P. Linares. Association between Patient-Controlled Analgesia Pump Use and Postoperative Surgical Site Infection in Intestinal Surgery Patients. Surgical Infections. Kyzer S, Ramadan E, Gersch M, Chaimoff C.

病患自控式止痛是最普遍被使用於术后疼痛控制的方法，但有报告显示使用PCA做术后止痛，会增加手术伤口的感染率，引起手术伤口感染的原因应考虑1材料污染2污染物的毒性3伤口的局部状况及4病人的抵抗力。

Topotecan is an effective agent for SCLC when used as monotherapy or in combined treatment, but myelosuppression such as leucopenia and thrombopenia was relatively severe. Although it has been recommended as a second-line agent for recurrence of sensitive SCLC, more clinical trials are needed to define its role in first-line treatment.

拓扑替康治疗小细胞肺癌有确切临床疗效，无论是单药还是与其他药物的联合用药均具有与当前一线经典方案相当的疗效，但具有相对高的致白细胞和血小板下降的骨髓毒性，已被认为是治疗化疗敏感的小细胞肺癌患者复发的二线推荐药物，但是作为一线用药仍然需要更多的实践来证实。

At last, the effects of JA on the bile salt resistance of Bifidobacteria were studied.The test proved that:Deoxycholic acid Na-Salt had intensely toxical action on Blm and Bbm;Adding glucose and fructose in media could decrease the lexical action on Bbm.but inulinand JAP had not apparent effect.

初步研究了菊芋对双歧杆菌的胆盐耐受性的影响，实验表明，脱氧胆酸钠盐对Blm和Bbm有一定毒性作用；在培养基中补充一定量的葡萄糖和果糖可以改善Bbm的胆盐耐受性，而菊糖和菊芋粉对提高Blm和Bbm的胆盐耐受性没有明显作用。

China has acceded to a series of major international arms control and disarmament treaties and conventions, including the Protocol for the Prohibition of the Use in War of Asphyxiating, Poisonous or Other Gases, and of Bacteriological Methods of Warfare, the Convention on Prohibition or Restriction on the Use of Certain Conventional Weapons Which May Be Deemed to Be Excessively Injurious or to Have Indiscriminate Effects, the Antarctic Treaty, the Treaty on Principles Governing the Activities of States in the Exploration and Use of Outer Space, Including the Moon and Other Celestial Bodies, the Convention on the Prohibition of the Development, Production and Stockpiling of Bacteriological and Toxin Weapons and on Their Destruction, the Treaty on the Prohibition of the Emplacement of Nuclear Weapons and Other Weapons of Mass Destruction on the Seabed and the Ocean Floor and in the Subsoil Thereof, and the Treaty on the Non-Proliferation of Nuclear Weapons.

中国参加了一系列重要的国际军控与裁军条约或公约，主要有：《禁止在战争中使用窒息性、毒性或其他气体和细菌作战方法的议定书》、《禁止或限制使用某些可被认为具有过分伤害力或滥杀滥伤作用的常规武器公约》、《南极条约》、《关于各国探测及使用外层空间包括月球与其他天体活动所应遵守原则的条约》、《禁止细菌及毒素武器的发展、生产及储存以及销毁这类武器的公约》、《禁止在海床洋底及其底土安置核武器和其他大规模毁灭性武器条约》和《不扩散核武器条约》等。

China has acceded to a series of major international arms control and disarmament treaties and conventions, including the Protocol for the Prohibition of the Use in War of Asphyxiating, Poisonous or Other Gases, and of Bacteriological Methods of Warfare, the Convention on Prohibition or Restriction on the Use of Certain Conventional Weapons Which May Be Deemed to Be Excessively Injurious or to Have Indiscriminate Effects, the Antarctic Treaty, the Treaty on Principles Governing the Activities of States in the Exploration and Use of Outer Space, Including the Moon and Other Celestial Bodies, the Convention on the Prohibition of the Development, Production and Stockpiling of Bacteriological and Toxin Weapons and on Their Destruction, the Treaty on the Prohibition of the Emplacement of Nuclear Weapons and Other Weapons of Mass Destruction on the Seabed and the Ocean Floor and in the Subsoil Thereof, and the Treaty on the Non-Proliferation of Nuclear Weapons.

中国参加了一系列重要的国际军控与裁军条约或公约，主要有：《禁止在战争中使用窒息性、毒性或其他气体和细菌作战方法的议定书》、《禁止或限制使用某些可被认为具有过分伤害力或滥杀滥伤作用的常规武器公约》、《南极条约》、《关于各国探测及使用外层空间包括月球与其他天体活动所应遵守原则的条约》、《禁止细菌及毒素武器的发展、生产及储存以及销毁这类武器的公约》、《禁止在海床洋底及其底土安置核武器和其他大规模毁灭性武器条约》和《不扩散核武器条约》等。注意，注意力集中

Firstly, the acute cytotoxicity of profenofos on FG-9307 cells was studied, it was found that the cell growth rate was markedly reduced by profenofos at all the concentrations tested; and that the fine structures of the cells were also altered by profenofos, as evidenced by dilation of nuclear membranes and mitochondria cristae, and presence of enlarged lysosomes with engulfed organelles and numerous vacuoles in the cytoplasm.

丙溴磷对FG-9307的急性细胞毒性研究结果发现：1）在所有实验浓度下，细胞的生长速度均受到抑制。2）细胞的超微结构被丙溴磷所改变，最明显的特征则是线粒体损伤严重，嵴肿胀，部分溶解破裂；核膜肿胀，有溶解；细胞内的电子密度高的溶酶体增多；内质网的膜溶解，核糖体从粗面内质网上脱落下来，游离于胞质中。

It is now known that seere hypoxia-ischemia may not cause immediate cell death, but may precipitate a complex biochemical cascade leading to the delayed deelopment of neuronal loss. These phases include a latent phase after reperfusion, with initial recoery of cerebral energy metabolism but EEG suppression, followed by a secondary phase characterized by accumulation of cytotoxins, seizures, cytotoxic edema, and failure of cerebral oxidatie metabolism from 6 to 15 h post insult.

现在认识到严重的局部缺氧有可能不立即引起细胞坏死，但是可能促成一种复杂的生化级联反应，这可能导致神经元丢失，进而导致延缓发育，这些时期包括再灌注后的潜伏期，该期出现早期的脑能量代谢复苏但脑电图却呈抑制状态，紧接着第二期表现为损伤后6－15个小时细胞毒素，癫痫，细胞毒性水肿，脑氧化功能衰竭的累积。

Of 17 objective responses, nine (38%) were partial responses, including two that were greater than 90%. Five patients (21%) had ORs lasting more than five months. Clinically meaningful PRs occurred in five of seven patients with pancreatic cancer, and in all three with neuroendocrine cancers.

其他与70 mg/m2的CIS有关的副作用包括第III级的耳毒性，以及三名患者中有二人出现第二级的神经病变，因此研究人员估计CIS的最高容许剂量为60 mg/m2，并且建议以此剂量作为第 II 阶段的研究剂量。

For drug substances with limited aqueous solubility (e.g., griseofulvin,nitrofurantoin), particle size can have a large effect on the behavior of the drugproduct, and significant differences in particle size may also affect toxicity.

对于有限的水溶性的原料药（如，灰黄霉素，呋喃妥因），粒度可能对制剂的性能有较大的影响，粒度的较大变化也可能会产生较大的毒性。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐