有毒性的

Bronchial asthma is the most common chronic diseases in children.Asthma can not be fully explained by imbalance of Thl/Th2.With the research progress of CD4+ CD25+ Treg cell,it has been found that CD4+ CD25+ Treg cell related factors such as forkhead/winged helix transcription factor,heine oxygenase-1,transforming growth factor-β,cytotoxic T lymphocyte-associated antigen-4 are closely linked to asthmatic mechanisms.

支气管哮喘是一种儿童时期最常见的慢性疾病，单纯的Thl/Th2应答失衡并不能完全解释支气管哮喘的发生，伴随着CD4+CD25+调节性T细胞的研究进展，人们发现与CD4+CD25+Treg细胞相关的因素如叉头/翼状螺旋转录因子、血红蛋白加氧酶-1、转化生长因子β、细胞毒性T淋巴细胞相关抗原-4与支气管哮喘均有密切的联系。

LOM could remarkably protect the hippocampus cells from the damage of QA.

LOM 对QA所致的海马神经元损伤有明显的保护作用，而QA所引起的兴奋毒性可能与Ca2+超载所造成的链式损伤有关。

Either electron-donating or electron-withdrawing group linked at the intercalation plane may increase the motility of π-bond and the molecular polarization, thus enhancing the intercalation.

2在刚性平面上引入特定长度的柔性侧链作为导向连接结构，可以增强DNA选择性结合的作用，这说明在抗癌药物设计中柔性侧链的引入可能对增大抗癌活性，降低毒性是有作用的。

Although the derivatives have lower toxicity, the curative effects are often lower than that of nitrogen mustard. And the toxic-side effect of the derivatives, such as bone marrow inhibition, cross-resistance, and mutation are still serious.

然而不幸的是这一问题并未得以解决，新的氮芥衍生物的毒性虽然小于氮芥，但细胞毒作用常低于后者，并且发现新的衍生物仍有相当的毒副作用，如骨髓抑制，交抗，致突变作用等。

Result:(1)Tau prevented neurons against Mn toxicity of low and middle concentrations. The ideal conditions can reach upon 4. 5 mM Tau added just, nearly no apoptosis cells could be detected.(2)The percentages of apoptosis intogether were lower than those in Mn just , being concentration-dependent relations with Taurine levels.(3)Mn induced DNA damage of neurons with dose-depedent, The higher of Mn concentration, the lengther of the comet tail and the higher percent comet-like cells. Tau incubated could weaken significantly the lesions of Mn towards DNA on the degree.

结果：(1)牛磺酸对中低剂量锰的毒性有一定的拮抗作用，单独加入牛磺酸效果最好剂量是4.5mM，视野下几乎不见凋亡细胞；(2)牛磺酸干预后培养神经细胞凋亡率低于相同剂量的单纯锰培养细胞组，且与牛磺酸浓度呈剂量依赖性；(3)锰引起培养神经细胞DNA损伤，表现在彗星尾长增加，彗星样细胞百分率增加；加入牛磺酸干预后，可明显改善锰造成的培养神经细胞DNA损伤。

The existing nonclinical data implicate not only NMDA-receptor antagonists, but also drugs that potentiate -aminobutyric acid signal transduction, as potentially neurotoxic to the developing brain.

现有的非临数据提示不仅 NMDA 受体拮剂还有其他强γ-氨基酸信号转换的药物对发育的大脑有潜在的神经毒性。

It was recently reported in Japan that effective component of the extract of Rubia Cordifolia L has obvious inhibition for leukemia, cancer of colon and carcinoma of the lung in mice, its curative effects equaled or exceeded to the catharanthine, mitomycin and adriacin and had less virulence for normal cells.

近来日本学者系川秀治等研究发现茜草提取物中的有效成分环己肽类化合物对小鼠的白血病、腹水癌、大肠癌、肺癌均有明显的抑制作用，其疗效等于或优于长春碱，丝裂霉素、阿霉素，并且对正常细胞的毒性低。

The author concludes his review by asking,"Where is the scientific evidence showing that GM plants/food are toxicologically safe, as assumed by the biotechnology companies?"

作者在评论中用询问作结论：&有哪里的科学证据去证明，正如生物技术公司自己所假设的一样：转基因植物/食物的毒性是安全的呢？&

Objective:to primarily find out the effect about luteolin rivalizing ototoxicity of gentamicin.methods: in this experimental study,gentamicin group was compared to the group of gentamicin with different dose of luteolin (10 mg,20 mg).the changes in hearing and vestibule function were discovered by measuring the threshold of abr and the frequency of eng.the method of cochlear preparation stained with sdh was used to observe morphological changes in cochleas.results: the auditory examination results showed that the thresholds of the group of gentamicin with different dose of luteolin were higher than the one of the gentamicin group,and the difference was significant in statistics.the morphology analysis result was consistent with auditory examination.

目的：初步了解木樨草素对庆大霉素耳毒性的影响。方法：设庆大霉素组与庆大霉素加不同剂量木樨草素（10 mg、20 mg）两组，并进行组间比较，观察听性脑干反应阈值、眼震电图的频率，了解其听功能及前庭功能的变化。结合耳蜗基底膜铺片琥珀酸脱氢酶染色方法观察耳蜗形态学变化。结果：听功能检查结果显示，庆大霉素加不同剂量木樨草素组的abr阈值明显低于庆大霉素组，经统计学处理，差异有显著性。形态学检查结果与听功能检查结果一致。

In what is, admittedly, the least-tested part of their thesis, Dr Unger and Dr Scherer argue that other cells react to this increase in leptin concentration by becoming resistant to the hormone's effects. That, in turn, stops them oxidising lipids and opens those cells to lipids' toxic effects.

昂格尔和谢勒博士的理论中有一部分证据最为不充分，在这一部分中，他们称其他细胞会对瘦素的累积产生反应，开始对激素的作用产生抵抗，从而不再对脂质进行氧化，是它们受到脂质毒性的攻击。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐