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有毒性的

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It is a colourless, oily, somewhat toxic liquid with a sweet, burning taste.

它是无色油状稍有毒性的液体,有甜而辣的味道。

Poisonous toxins to actually melt out of the plastic wrap and drip into the food.

於食物是裸露的,高热会让有毒性的戴奥辛,自塑料包裹膜中熔出,而滴

As the food is nuked, the high heat causes poisonous toxins to actually melt out of the plastic wrap

由于食物是裸露的,高热会让有毒性的二恶英,自塑料包裹膜中熔出,而滴入食物。

As the food is naked, the high heat causes poisonous toxins to actually melt out of the plastic wrap and drip into the food.

由于食物是裸露的,高热会让有毒性的戴奥辛,自塑料包裹膜中熔出,而滴入食物。

As the food is nuked, the high heat causes poisonous toxins to actually melt out of the plastic wrap and drip into the food.

由于食物是裸露的,高热会让有毒性的戴奥辛,自塑料包裹膜中熔出,而滴入食物。

Most of new drugs are very toxic at the moment.

目前大部分新药物都是有毒性的

Medicine is used to unclose and seize mysterious physiology, pathology and pathogeny of human body, and solve problems pointedly and flexibly, but it is difficult to find a versatile medicine, operation or treatment means. So, some people cannot get away from illness despite medical treatment, some even die. Sometime, medicines are suitable for adult A, but not for adult B who has the same sickness, or do harm to infant A even lead to death; some patients get better by taking virose medicines, but others disable or die; suffering from the same sickness, some people pull through and live for another tens of years, some people die in the operating table; sickness recrudesces in some people whose families break up after several operations, etc.

医学能把人体深层奥秘的生理、病理、病因揭开并掌握,还可以针对性或应变性解决,但难以制造出广谱特效的药物和手术及用各种治疗手段来解决,所以有的病经久治疗难愈,有的病被治死,有的药可以治愈同一种病的甲成人,而不能治愈同一种病的乙成人,或对甲小儿有害甚者易致残亡;有病人服有毒性的药可以治愈病,但有的人服后致残或死;同一种病,有人手术后恢复健康活至几十年,有人死于手术台;有的手术后病情复发,然经几次手术后家破人亡,等等。

There are several D-amino acid itself is toxic to plants even in the relative low concentration of D-amino acids because many plants lack the normal channels of D-amino acid oxidation deamidation, Therefore, we can use D-amino acid lyase having the toxicity to plant as a safe selectable marker.

对植物来说,很多组织缺乏正常的途径对D-氨基酸进行氧化脱氨基作用,由于这种消化系统的不同导致的结果是,有几种D-氨基酸本身对植物是有毒性的,即使在D-氨基酸相对浓度较低的情况下。

Glioma is still one of refractory disease in the neurosurgical field; the development of new primary and adjuvant treatment is vital. Recently, the gene therapy of glioma is developed rapidly and there are many methods about the gene therapy that include: suicide gene therapy, immunologic gene therapy, drug resistangce gene therapy, angiostatin gene therapy and so on. The sucide gene therapy is the most potential approach of antitumer, these nonmammalian genes encode enzyme that convert nontoxic prodrugs into highly toxic metablites. Cells transfected with suicide genes are targeted for specific negative selection, witch can be induced by administrtion of the corresponding produg. Among the enzyme/produg combinations, two of the best characterized system are herpes simplex virus thymidine kinase /ganciclovir and Escherichia coli cytosine deaminase /5-flourocytosine (5-FC). The formor can convert the antiviral nucleoside analogs acyclovir , ganciclovir to their nucleoside monophosphate derivatives, the monophosphate forms are subsequently phosphorylated by endogenus cellular kinases to triphosphates, these molecules are potent inhibitors of DNA synthesis.

近年来脑胶质瘤的基因治疗发展迅速,应运而生的方法有自杀基因、免疫基因、多药耐药基因以及抗血管生成基因等,其中自杀基因被认为是最有前景的基因治疗方法,它又称病毒介导的酶/药物前体疗法,是利用转基因技术将哺乳动物细胞中所不含有的自杀基因转入到哺乳动物肿瘤细胞中,该基因表达的产物可将无毒的药物前体转化为毒性药物,从而选择性杀伤该肿瘤细胞,常用的自杀基因有单纯疱疹病毒-胸苷激酶基因和大肠杆菌胞嘧啶脱氨酶基因,前者催化无毒性抗病毒核苷类似物如丙氧鸟苷、无环鸟苷等成为单磷酸核苷衍生物,然后在内源性细胞激酶作用下转化为具有明显毒性的三磷酸核苷,作为DNA合成链的终止剂和DNA合成酶的抑制剂,干扰细胞DNA的合成;后者编码的胞嘧啶脱氨酶可催化5-氟胞嘧啶(5-FC)脱氨成为5-氟尿嘧啶(5-FU),然后代谢为有毒性的5-氟尿嘧啶-5′三磷酸(5-FUTP)和5-氟-2′脱氧尿嘧啶-5′磷酸(5-FdUTP),5-FUTP通过与UTP竞争性结合而抑制mRNA和tRNA的合成,5-FdUTP则作用于胸苷合成酶,导致TMP衰竭而阻止DNA的合成,最终诱导肿瘤细胞凋亡。

The use of penicillins in veterinary medicine does not present the same risks of hypersensitivity in animals as in humans. Although incidents of hypersensitivity have been recorded in horses and dogs, there are other materials which are toxic to certain species, e.g. the ionophore antibiotics in horses.

在兽用药中使用青霉素并不存在人用时过敏的危险,虽然有偶然的关于马和狗对青霉素有过敏的报导,有些药物对某些动物甚至是有毒性的,如离子载体抗生素对马。

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