有效部分

Our results indicate that 1 NSC606985, at nanomolar level, can effectively induce apoptosis in AML cells NB4 and U937 and significantly inhibit the proliferation without cell death in breakpoint cluster region–Abelson murine leukemia kinase-carrying leukemic K562 cells; 2 At such low concentrations, this agent also significantly inhibits the clonogenic activity of hematopoietic progenitors from patients with AML; 3 For apoptosis induction, NSC606985 rapidly induces the proteolytic activation of protein kinase Cδ with loss of mitochondrial transmembrane potential and caspase-3 activation; 4 Co-treatment with rottlerin, a PKCδ-specific inhibitor, completely blocks NSC606985-induced mitochondrial m loss and caspase-3 activation, while the

结果显示：(1)纳摩尔浓度的NSC606985即可有效诱导AML细胞系NB4和U937细胞凋亡并显著抑制含有bcr-abl融合蛋白激酶的K562细胞的增殖；(2)低浓度的NSC606985也显著抑制来自AML病人骨髓的新鲜白血病细胞的克隆形成能力；(3)除了迅速诱导线粒体跨膜电位的崩塌及Caspase-3的活化外，NSC60698也导致蛋白激酶Cδ的水解激活；(4)PKCδ特异的抑制剂rottlerin能够完全抑制NSC606985诱导的线粒体跨膜电位的崩塌和Caspase-3的活化，而Caspase-3特异的抑制剂z-DEVD-fmk仅能部分削弱PKCδ的活化及细胞的凋亡；(5)以移植PML-RARα转基因小鼠产生的白血病细胞建立的模型研究了该化合物对白血病可能的治疗作用。

This Agreement and every provision hereof shall be deemed to be severable and, in the event that any paragraph is invalid or illegal, or shall be construed as preventing the formation of a valid binding contract between the parties of the Agreement, any such paragraph shall be deemed to be stricken from the Agreement, and the remainder of this Agreement shall continue to be in full force and effect as though such paragraph was not contained in this Agreement.

本协议和协议各条款应被认为是可分离的。若有任何段落无效或是不合法，或是妨碍形成对双方都有约束力的协议，该段落应该被认为从协议删除。协议的其他部分仍然有效。

After the balance of sediment depositing and sluicing is achieved, the effective reservoir volumes can regulate both water and silt for a long term.

两库淤沙与冲淤排沙达到平衡以后，虽然部分库容被淤，但是保留下来的有效库容能够长期调水调沙。

Take as a single example this easily overlooked little passage from the rondo of the 23rd piano concerto; it is, in its essence, nothing more than a functional bit of connective tissue taking us from one place to another within the movement's structure. Ten brief bars—about 10 seconds—of basic scalar material, doing its job efficiently and economically. But it is at the same time so richly and amusingly characterized, so full of piping energy, with its determined but struggling piano line climbing its stutteringly inexorable way up to the note E, punctuated along its course by deadpan commentary from the winds, sneaking in the D natural that signals the change of key with almost undetectable sleight of hand—the passage almost constitutes a miniature comic universe all by itself.

请听这段在《第23钢琴协奏曲》中常常被人忽视的回旋曲( http：//img.slate.com/media/87/7_mozart488.asf )，没有哪个功能性连结段能比它更好地仅通过乐章结构就将听众带入另一个世界，长约10秒钟的概要部分(brief bars of basic scalar material)不仅经济有效地发挥其职能，同时又表现出丰富、诙谐的特色，充满木管乐器的活力，伴随着坚决但阻碍不断的钢琴的快速音群移入E大调，其行进过程不时被管乐器部加以修饰、注解，自然而然的转为D大调，转调手法之娴熟几乎无法察觉——这段音乐本身创造出一个微缩的喜剧世界。

The tetrazine high-nitrogen energetic materials are new kinds of ones researched and reported widely at home and abroad in recent years.

四嗪环是一种含氮质量分数达68.3%的六元氮杂环含能基团，是设计高能钝感含能材料中非常有效的结构单元；四嗪类高氮含能材料也是近年来国内外研究和报道较多的一种新型含能材料，部分具有生成焓高、热稳定性好和感度较低等特点。

The tetrazine high-nitrogen energetic material s are new kinds of ones researched and reported widely at home and abroad in recent years.

四嗪环是一种含氮质量分数达68.3%的六元氮杂环含能基团，是设计高能钝感含能材料中非常有效的结构单元；四嗪类高氮含能材料也是近年来国内外研究和报道较多的一种新型含能材料，部分具有生成焓高、热稳定性好和感度较低等特点。

Tetrazine ring is an energetic nitrogen hexa-heterocyclic group with nitrogen mass fraction of 68.3%,so it is a very effective structure unit in the design of high energetic,insensitive materials.The tetrazine high-nitrogen energetic materials are new kinds of ones researched and reported widely at home and abroad in recent years.

四嗪环是一种含氮质量分数达68.3%的六元氮杂环含能基团，是设计高能钝感含能材料中非常有效的结构单元；四嗪类高氮含能材料也是近年来国内外研究和报道较多的一种新型含能材料，部分具有生成焓高、热稳定性好和感度较低等特点。

Additionally, a programmable bus-hold latch is available to hold tristate outputs in their last valid state until the bus is driven again by some device.

此外，一个可编程的总线保持锁存可用来举行他们的最后一个有效的状态，直到三态输出总线驱动部分设备再次。

The question is with embodying in insufficiently mainly: The electoral procedure is not enough for the norm ; Elect through bribery , village two committee intensification , excessive existence of intervention of villages and towns of contradiction influence fairness and quality that elect; Detest ubiquitously and select troublingly; The defect of the legal system is unfavorable to the protection of the right of voter , has limited the enforcement of some rights of voter such as voter"s resignation system, fire procedure perfection is it to supervision , village committee of member , the most important thing is villager elect right lack effective legal protection and relieve mechanism to infavorableto, can"t ensure villagers election right , has dampenned the enthusiasm that peasants participate in politics seriously, it is apt to bring out a great deal of destabilizing factors.

问题与不足主要体现在：选举程序不够规范；贿选、村两委矛盾的加深、乡镇过分干预的存在影响了选举的公正与质量；普遍存在的厌选令人担忧；法律制度的缺陷不利于对选民权利的保护，如选民登记制度限制了部分选民权利的行使，罢免程序的不完善不利于对村委会成员的监督，最重要的是村民选举权利缺乏有效的法律保护和救济机制。

In tank seismic design considered the liquid sloshing, hydrodynamic pressure of tank shell, uplifting condition of unanchored tank and effective bottom plate width.

而未锚定储槽的槽壁上举状态分析，应将有效上举部分的底板列入设计考量，这些都是储槽耐震分析的重点。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐