有变化的

Note: pregnancy, lactation, severe liver damage, jaundice, or a continued itching during pregnancy, Dubin-Johnson syndrome, Rotor syndrome, liver cancer or a history of liver tumors, thromboembolic, or a history of sickle-cell anemia, breast cancer or endometrial cancer, vascular changes associated with severe diabetes, lipid metabolism disorders, should be used with caution.

注意事项：妊娠，哺乳，严重的肝功能损害，黄疸或在妊娠期有持续瘙痒，Dubin-Johnson综合征，Rotor综合征，肝脏肿瘤或有肝脏肿瘤病史，血栓栓塞或病史，镰状细胞性贫血，乳腺癌或子宫内膜癌，伴有血管变化的严重糖尿病，脂质代谢紊乱，均应慎用。

Modern approach methods of geography, ecology, quantitative analysis, expert integration, remote sensing image analysis and geographical information system were combined to reveal the matters in this paper. The eco-geographical background of the research area and the research work studied by other scholars were comprehensively expatiated. The temporal and spatial variation of precipitation and soil moisture, vegetation and soil distribution, and land use/land cover were compared as well. On the basis of foregoing analysis, the eco-geographical differentiation was discussed. According to principles and indicators, with extension engineering method and integrated analysis, the physical geography boundary between subhumid and semiarid areas were demarcated. By using remote sensing image analysis, wavelet analysis of the perennial precipitation and temperature, and the comparison of temporal and spatial variation of the desertification, this paper accounted for the regional response to global environmental change and suggested the dominant environmental problems.

本文采用了地理学与生态学相结合、定量分析与专家集成相结合、遥感图像解译和地理信息系统相结合的方法，对研究区的生态地理背景和已有研究工作进展情况给予了全面的分析和阐述；通过对区域水分条件（大气降水、土壤水分条件）、植被、土壤、土地利用／土地覆被状况等环境要素的时间与空间特征的对比分析，探讨了研究区内部生态地理特征的差异；在一定的原则指导下，通过建立指标体系，以可拓工程方法和模型为支撑，经过综合分析确定了研究区内半湿润、半干旱区界线划分方案；通过遥感图像解译、典型站点多年降水与温度的小波分析、土地沙漠化时空变化的对比分析等，说明了研究区域对全球变化的响应；表明了该区域所面临的主要环境问题。

Mi's characters were strongly influenced by those of Wang Hsien-chih and have an untrammeled and expansive feeling.

米芾的字受王献之影响最深，有一种俊逸疏爽之气，在北宋四大家中，米字的笔法和速度最灵活而有变化。

Simulation results show that the system has better control performance and estimation effect , but the influence of parameters variation on speed estimation error is evident .

仿真结果表明该系统有较好的控制性能和辨识效果，但参数变化对速度辨识误差有明显的影响。

The main food items also varied monthly, and changed from small-sized to relative large-sized species. The main diet composition included polychaeta and crab in May, fish and amphipoda in June, fish and polychaeta in July, empty stomach in August, and fish and shrimp in September.

主要饵料生物组成有明显的月变化，且食物个体有逐渐增大的趋势，其中5月主食多毛类和蟹类，6月主食鱼类和端足类，7月为鱼类和多毛类，8月样本较少且为空胃，9月为鱼类和虾类。

About the style I study the close intrinsic relationship between his preferring to prose and his philosophy of life and how the changes of his prose style show the ones of his thoughts. Concerning the subject matter of writing I discuss how Zhou" s loving life and "common humanity influenced it. For example, he like to write the fate of unimportant person, the local snacks, the folk arts, the slight changes in nature and so on. As regard to the genre of writing, I set forth that the contradiction of his philosophy of life make his works present the contradictious style which not only is peaceful but also shows his teeth.

关于文体，着重研究周作人的人生哲学和他对散文的偏爱有什么样的内在联系以及他一生不断创造和尝试不同的散文体式背后的思想变化；关于题材，着重论述周作人对生命的关注热爱与&平凡人道观&在其选材上的体现，如喜欢写小人物的命运故事、不起眼的地方小吃和民间手工艺、大自然的细微变化等等；关于风格，着重阐述周作人人生哲学的矛盾性如何使他的散文也呈现出一种&平淡腴润&与&浮躁凌厉&矛盾统一的复杂艺术风貌。

The growth inhibiting rate of T24 cell lines were detected by MTT methods, apoptosis of cells were detected by flow cytometry, the mechanism of apoptosis was analyzed by detecting the protein expression of Bcl-2, Bax, Caspase-9, Caspase-3 and cytoplastic protein Cytochrome C. 4 We injected live T24 cells into the subcutaneous space of nude mice and successfully built up the animal model of bladder carcinoma. The effect of CS-PAA-EPI polymer magnetic microspheres targeting chemotherapy was investigated by HE staining, TUNEL ,tumor weight and volume inhibition rate. Results: 1 TEM revealed that the CS-PAA polymer magnetic microspheres were regular spherical shape,the average diameter was 80nm in dry condition. By controlling the pH value of the medium,polymers had positive or negative zeta potential. VSM showed the CS-PAA polymer magnetic microspheres had superparamagnetic. The diameter of CS-PAA-EPI polymer magnetic microspheres were 200nm in solution by DLS examining,the embedding ratio was 20%,the EPI loading rate was 15%, which was higer than reported in other articles. 2 Raw eye observation found that the rat"s bladder of treatment group was brown color,which meaned the aggregation of iron particles, compared with the control group, iron stain found iron particles were assembled in rat"s bladder of the treatment group, the amount of iron particles in liver and spleen were less obviously.

研究结果：1合成的CS-PAA磁性聚合物微球呈球形，大小均一，TEM测定其干态下粒径为80nm左右，磁化曲线证实具有超顺磁性，具有一定的PH敏感性，固载表柔比星后，水溶液性状稳定，无沉淀物，DLS测定直径约200nm左右，测定载药率为15％，较文献报道高，包封率为20％。2肉眼观察试验组大鼠膀胱表面呈褐色，可见大量的Fe粒子聚集，普鲁士兰染色法显示，试验组大鼠膀胱壁内有大量的Fe粒子，分布至膀胱壁全层，与对照组大鼠相比，试验组大鼠的肝、脾内的Fe粒子聚集量明显降低；HPLC测定结果与Fe染色相同；高剂量磁性CS-PAA-EPI生理盐水组及单纯EPI生理盐水组均在给药后14天出现血肌酐和尿素氮的升高，其他组大鼠血生化指标没有明显变化。3MTT法发现，高、中、低剂量磁性CS-PAA-EPI生理盐水组在外加磁场的协同作用下杀伤T24细胞效应明显高于单纯的EPI生理盐水组，FCM发现试验药物组可引起明显的肿瘤细胞凋亡，试验药物治疗组细胞胞浆内出现了由线粒体释放出的细胞色素C，试验组细胞Bcl-2蛋白减少，Bax蛋白变化不明显，Caspase-3、Caspase-9蛋白受到了激活活化。4高、中、低剂量磁性CS-PAA-EPI生理盐水组的瘤重抑制率和瘤体积抑制率均明显高于单纯的EPI生理盐水组(P＜0.01)，其中高剂量组的抑制率最高。

It was found from the structure-electrochemical studies of cytochrome c that (1) the secondary and tertiary structural changes of cytochrome c are greatly influenced by the reductions of tyrosine residues and iron ions in heme;(2) the reduction reaction dose not induce the configuration transition;(3)α helix, parallel β sheet, antiparallel β sheet and random coil take part in the complex secondary structural transitions;(4) mechanism and parameters about the electroreduction have also been obtained.

在细胞色素c的结构-电化学研究中发现：（1）细胞色素c的二级和三级结构受电场和酪氨酸残基及血红素中Fe的电化学还原的影响，其中酪氨酸残基还原的影响较大；（2）细胞色素c的电化学还原没有发生构型转化现象；（3）细胞色素c参与二级结构变化的构象有α螺旋，平行β折叠，反平行β折叠和无规卷曲；各组份随电位的变化复杂；（4）获得细胞色素c电化学还原的机理和参数

Years of Chinese real estate, but was staged in Hainan, a large, real estate Enlightener Hollywood blockbusters like to attend the meeting in the single-pole, hero At that time, the soul-stirring only a small number of people; in 1998, real estate was thrown after the market-oriented, there are known as real estate development was "encircled monopoly"-like, until 2002, real estate development of only 10% of the investment banks can borrow撬起leverage of the secret is no secret that the world only on indictment, when the real estate belongs to a circle Ambilight; in 2005, up to the circle containment wall finally collapsed, re-allocation of resources, every resource structure the changes are drastic changes in the pattern of a business opportunity, even if the profits of real estate development from 30% to 10%, but outside of people, here is still the land of the return on investment.

一九九三年的中国房地产，但分别在海南，一个大型，房地产启蒙好莱坞大片要出席这次会议的单相，英雄在这当时，惊心动魄，只有少数的人；在1998年，房地产被抛出后，以市场为导向，有被称为房地产开发&包围垄断&一样，直到2002年，房地产开发的只有10个％的投资银行可以借用杠杆撬起的秘密是什么秘密，世界上只有公诉，当房地产属于一个圆圈流光溢彩；在2005年，最多的圆圈，终于遏制墙倒塌，重新分配资源，每一个资源结构的变化是急剧变化的商业模式的机会，即使利润的房地产开发由30 ％至10 ％，但外面的人，这里仍然是土地上的投资回报率。

All results above indicated that:The expression of ERβand p-ERβin mouse ovary at oestrous cycle and in early gestational period changed regularly, it showed that ERβand p-ERβhad important effects to ovaries development, ovarian follicles groth, oocyte maturation and form corepus luteum in female mouse ovary during oestrous cycle and in early gestational period.

以上结果表明：ERβ及其磷酸化形式——p-ERβ在小鼠发情周期以及妊娠早期卵巢中表达有规律性的变化，揭示ERβ与p-ERβ在雌性小鼠发情周期及妊娠早期，对卵巢发育、卵泡生长、卵母细胞成熟和黄体形成有重要的作用。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。