月桂酮

ABSTRACT Aim: To study the effect of laurocapram and its mixed transdermal accelerator on the transdermal absorption of benzocaine.

摘 要 目的：研究月桂氮酮及其混合透皮促进剂对苯佐卡因透皮吸收的影响。

Objective: To investigate the effect of different concentration lauric azone on absorption through skin.

目的：研究不同浓度月桂氮酮对透皮吸收的影响。

The penetrative rate of diclofenac acid was smaller than that of diclofenac sodium in carbopol.

双氯芬酸钠从含有月桂氮酮的凝胶中透皮扩散的速率比从相应没有月桂氮酮的凝胶中透皮扩散的速率有所增加，但增加的程度不明显。

The main components of santolina essential oil are artemisia ketone; vulgarone;β-Phellandrene; curcumene; myrcene; sabinene; and β-Pinene, accounting for 83.44 percent of the total content and 887.5μL/kg·FW in terms of absolute content.

2银灰菊精油主成分为蒿酮、vulgarone、β-水芹烯、姜黄烯、月桂烯、桧烯、β-蒎烯等，总百分含量占83.44%，总绝对含量为887.5μL/kg·FW。

After ultra high pressure treatment, limonene concentration was decreased greatly while myrcene and α-pinene concentrations were not changed significantly and the concentration of limonene was decreased by 75% after high pressure treatment of 500 MPa for 15 min,α-terpineol and carvone concentrations were increased significantly. The aldehydes concentrations were retained well. The ester concentrations were changed under high pressure treatment, but generally their concentrations were not changed remarkably.

通过定量检测分析发现：超高压处理对橙汁中的柠檬烯成分影响很显著，经500 MPa的压力处理15 min后其含量下降了75%，而月桂烯和α-蒎烯受高压影响较小；α-松油醇、香芹酮含量经高压处理后迅速增加；醛类特征香气成分基本不受高压影响；酯类成分在高压下会发生变化，但总体变化不显著。

Result: The flux of anemonin permeating through human skin from 30% ethanol, 50% ethanol solution and a combination of 3 % laurocapm -5% polysorbate 20 and 30 % ethanol -3 % laurocapm -5% polysorbate 20 of anemonin was (9.30±0.32),(18.56±0.58),(7.29±0.35),(13.77±0.16)μg·cm-2·h-1 and 7.9, 15.9, 6.2, 11.8 times higher than from saturated water solution respectively.

结果：白头翁素饱和水溶液的稳态渗透速率为(1.17±0.03)μg·cm-2·h-1，含30%、50%乙醇和3%月桂氮酮-5%聚山梨酯20、30%乙醇-3%月桂氮酮-5%聚山梨酯20的白头翁素溶液稳态渗透速率为(9.30±0.32)，(18.56±0.58)，(7.29±0.35)，(13.77±0.16)μg·cm-2·h-1，分别使白头翁素的经皮渗透速率提高了7.9，15.9，6.2，11.8倍。

Amino-6-methoxy Benzothiazole 99%、2-Amino Benzothiazole 99%、Veratraldehyde 99%、Veratric Acid 99%、1,2- Dimethoxy Benzene 99%、6-Nitroveratric Acid 97%、2,5-Dichlorobenzoic Acid 99%、4-Chloro-3-Nitrobenzoic Acid 99%、 3-Nitrobenzole Acid 98%、p-Methoxybenzoie Acid 99%、Anisole 99.5%、p-Methoxyacetophenonc 99%、(2'-Chloroethyl) Benzene 99%、(2'-Bromoethyl) Benzene 99%、N,N-Diethyi-m-Toiuamide 99%、Aminoacetonitrile Hydrochloride 98%、 Alkyl Diphenyl Phosphate Estrel 98%、5-Chloro-2-benzothiazolone 99%、6-bromo-2-naphthol 98%、6-Nitro-Veretric Acid Estrel 97%、4-chloro phenoxyaeetic 99

2-氨基-6-甲氧基苯骈噻唑、2-氨基苯骈噻唑、藜芦醛、藜芦酸、藜芦醚、6-硝基藜芦酸、2，5-二氯苯甲酸、3-硝基-4-氯苯甲酸、3-硝基苯甲酸、对甲氧基苯甲酸、苯甲醚、对甲氧基苯乙酮、β-氯代苯乙烷、β-溴代苯乙烷、N，N-二乙基间甲苯甲酰胺、氨基乙腈盐酸盐、磷酸二苯月桂酯、5-氯-2-苯骈噻唑酮、6-溴-2-萘酚、6-硝基藜芦酸甲酯、4-氯苯氧乙酸

Aroma components of Hexylalcohol,Benzeneethanol,Butylalcohol,Pentylalcohol, ethyl acetate, Lactic acid ethylester, Butanedioic acid,diethylester, isopentylacohol acetate, acetic acid hexylester, acetic acid phenethylester, hexanoic acid ethylester, ethyl caprylate, decanoic acid ethylester, octanoic acid, linalool andα-terpineol were identified in former kiwi wine reports.

本试验首次在猕猴桃酒中发现了油酸乙酯，棕榈酸乙酯，9-癸烯酸，肉豆蔻酸乙酯，月桂酸乙酯，香茅醇，法呢醇，异薄荷酮香气物质，目前国内外资料中报道的猕猴桃酒香气物质—己醇，苯乙醇，丁醇，戊醇，乙酸乙酯，乳酸乙酯，琥珀酸二乙酯，乙酸异戊酯，乙酸己酯，乙酸苯乙酯，己酸乙酯，辛酸乙酯，癸酸乙酯，辛酸，芳樟醇，α-松油醇等均在本试验研究中也检测出，并得到证实。

Results: Absorbances of Bahenxiao Paste are different with different concentration of lauric azone; and absorbances of identical concentration are linear related to time.

结果：不同浓度月桂氮酮的涂膜剂的体外透皮吸收溶液吸光度不同，同一浓度月桂氮酮的涂膜剂的体外透皮吸收溶液与时间变化成线性关系。

Study on the Effect of Azone on Percutaneous Absorption of Clindamycin Hydrochloride in Cream;2. OBJECTIVE To observe the effects of three transdermal enhancers( azone ,isopropyl myristate,oleic acid) in vitro under the condition of iontophoresis with diclofenac sodium as the model drug.

方法选择聚乙烯醇、聚乙烯吡咯烷酮、羟丙甲基纤维素为基质，制备了分别含有月桂氮酮、肉豆蔻酸异丙酯和油酸的双氯芬酸钠经皮离子导入凝胶，采用改良Franz纵向释放池，以人体皮肤为透皮屏障，进行药物凝胶的离子导入经皮试验。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失