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Journal of Antimicrobial Chemotherapy Advance Access publication 6 December 2005 OXE β-lactamases in Acinetobacter:the story so far Molecular Chemotherapy,Centre for Infectious Diseases,University of Edinburgh,The Chancellor's Buliding,49 Little France Crecent,Edinburgh,EH16 4SB,UK The emergence of carbaoenem resistance in Acinetobacter baumannii has become a global concern since these β-lactams are often the only effectine treatment lsft against many multiresistant strains.A recent debelopmenth has the discovery of a novel group of narrow-spectrum OXA β-lactamases in carbapenem-resistant strains,some of whitch have acquired the ability to hydrolyse the carbapenems.The first of these was found in a strain isolated in Edinburgh before imipenem was in usr in the hospital.Whether these carbapenemases have been acquired or are part of the genetic make-up of this species has yet to be determined.More importantly,however,they represent an important stage in the evolution of antibiotic resistance in Acinetobacter.This paper discusses the emergence of these unusual enzymes over the past decade.

抗菌化学疗法》杂志上 2005年12月6日提前存取出版在不OXEβ-lactamases:到目前为止分子化疗,中心为传染性疾病,爱丁堡大学,议长,49岁的法国Crecent少、爱丁堡、EH16 4SB,英国 carbaoenem电阻的出现在鲍曼不动杆菌已成为全球关注这些β-lactams通常是唯一effectine对抗许多multiresistant菌株治疗lsft…最近的一debelopmenth已发现的一种β-lactamases仅OXA集团在carbapenem-resistant株,其中一些已经取得了hydrolyse能力的carbapenems第一个被发现在一株孤立在爱丁堡的药物有亚胺培南在使用之前在医院这些carbapenemases是否已经或正在部分的基因构成该物种还有待确定然而更重要的是,他们代表着一种重要阶段的抗生素耐药性的演化出不本文探讨了产生这些不寻常的酶在过去的十年。

At a recent conference in Singapore on regional security, organised by the London-based International Institute for Strategic Studies, Singapore's prime minister, Lee Hsien Loong, said that how China and the West handled problems caused by "narrow interest groups"(apparently referring to the pro-Tibet lobby and its ilk), would "strongly influence whether China's emergence will unsettle the international order, or whether China succeeds in its path of peaceful integration with the rest of the world."

最近在新加坡举行的由伦敦国际战略研究所组织的一次地区安全会议上,新加坡总理李显龙说:中国和西方国家如何处理由"狭隘利益集团"(显然是指亲西藏的游说团体及其同类)引发的问题,将"严重影响中国的出现是否会破坏国际秩序,或中国能否成功实现其与世界其它部分的和平一体化。"

"Mysterious ice grain " Pluto once was fully favoured by "constellation fan " and uncounted astrophil, unfortunately "greatly "be laid-off" in reducing the staff the solar system", on August 24 , 2006 late in nearest once, the representative at the meeting takes it as an excuse that "whose insufficient big prepare a track and adjacent to mass planets part coincides ", unanimous decision "gives Plutonian planet qualification the sack", and demotes the person for average short planet on international astronomy federation annual meeting holding in Prag.

曾经备受"星座迷"和无数天文爱好者宠爱的"神秘冰谷"冥王星,不幸在最近的一次太阳系"大裁员"中"下岗",2006年8月24日晚,在布拉格举行的国际天文学联合会年会上,与会代表们以"其质量不够大和轨道与邻近行星部分重合"为由,一致决定"开除"冥王星的行星资格,并将其降级为普通的矮行星。

Canadian architects Saucier Perrotte shared with us their finalist proposal for the Planetarium de Monteral competition , a black mantle connecting the different programatic pieces .

建筑事务所最近和我们分享了他们为蒙特利尔天文馆设计竞赛所做的最后参赛方案--一个黑色的斗篷将所有不同的部分连接起来。

Canadian architects Saucier + Perrotte shared with us their finalist proposal for the Planetarium de Monteral competition, a black mantle connecting the different programatic pieces.

加拿大Saucier + Perrotte建筑事务所最近和我们分享了他们为蒙特利尔天文馆设计竞赛所做的最后参赛方案——一个黑色的斗篷将所有不同的部分连接起来。

The walls held Amarrian religious icons, forms and images, but most of these were partly covered by the recently hung banners of House Sarum.

墙壁举行Amarrian宗教图标,表格和图片,但其中大部分被部分所涵盖最近挂横幅众议院Sarum 。

Second in this group come those parts of the Sibylline Books whose date, as Geffken's recent critical analysis has established ("Komposition und Entstehungszeit der Oracula Sibyllina," pp. 7-13), is about the year 83 BC The Messiah is pictured (verses 652-666) as a king sent by God from the rising of the sun, who will put an end to war all over the earth, inasmuch as he will destroy some peoples and make permanent treaties with the others; in all his actions he will be solicitous not to follow his own counsel, but to obey the commands of God.

第二,在这个小组来那些部分的知未来的书籍,其日期, geffken最近的批判性分析已成立(下称" komposition und entstehungszeit明镜oracula sibyllina ,"聚丙烯7-13 ),是关于今年83公元前弥赛亚是图(小诗652-666 ),作为国王派出的上帝,从上升的太阳,他们将结束所有战争超过地球,因为他会破坏一些民族和长期措施,使条约与他人在他的所有行动,他将被solicitous不跟随他自己的律师,但必须绝对服从命令的上帝。

In its most recent season the Met, which gets 50% of the box-office revenue from simulcast tickets (sold at an average price of $22), more or less broke even with the scheme.

Met从同步直播的票房收入中抽取50%分成(同步直播的票价平均是22美元),在最近的演出季里,即使算上这部分分成Met也几乎入不敷出。

A recent study found that a five per cent increase of birds in the skua diet would result in an annual loss of thousands of other seabirds.

最近的一项研究发现,贼鸥的食谱中海鸟的部分增加5个百分点,就意味着每年多损失数千只海鸟。

The latest video from Somalia's Al-Qaida-backed Al-Shabaab wing is as slickly produced as a reality TV show but with a startling message complete with a hip-hop jihad vibe.

据美国有线新闻网报道,"基地"组织索马里分支"青年党"最近公布的录像出现了新的"圣战"宣传方式,在视频结尾部分,他们根据"圣战"的精神制作了一段流畅的说唱音乐舞曲。

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The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应,而且减少跟风的可能性。

The new PS20 solar power tower collected sunlight through mirrors known as "heliostats" to produce steam that is converted into electricity by a turbine in Sanlucar la Mayor, Spain, Wednesday.

聚光:照片上是建在西班牙桑路卡拉马尤城的一座新型PS20塔式太阳能电站。被称为&日光反射装置&的镜子将太阳光反射到主塔,然后用聚集的热量产生蒸汽进而通过涡轮机转化为电力