替换

Methods Blood samples were obtained from 5 patients with AIDS, the C2~C3 region of HIV-1 envelope gene was amplified by nested polymerse chain reaction from plasma of each patient, and then subject to sequencing, clonal-quasispecies analysis, and the accumulation of synonymous and nonsynonymous substitutions as well as ds/dn ratios were calculated.

采用套式聚合酶链反应方法对5例艾滋病患者血浆HIV-1 env基因C2~V3区进行PCR扩增，产物经纯化后克隆至pMD-18T载体中，每例患者分别挑取5~8个克隆，共34株，完成阳性克隆的鉴定、抽提纯化和测序，将获得的DNA序列及核苷酸序列进行分析，并计算其核苷酸同源替换率与非同源替换率的比值。

Blood samples were obtained from 5 patients with AIDS, the C2~C3 region of HIV-1 envelope gene was amplified by nested polymerse chain reaction from plasma of each patient, and then subject to sequencing, clonal-quasispecies analysis, and the accumulation of synonymous and nonsynonymous substitutions as well as ds/dn ratios were calculated.

采用巢式PCR方法对5例艾滋病患者血浆HIV-1env基因C2~V3区进行PCR扩增，产物经纯化后克隆至pMD-18T载体中，每例患者分别挑取5~8个克隆，共34株，完成阳性克隆的鉴定、抽提纯化和测序，将获得的DNA序列及氨基酸序列进行分析，并计算其氨基酸同源替换率与非同源替换率的比值。

These results indicated that the genetic variation within exon 2 appeared to have largely arisen by gene recombination and balancing selection. Alignment of the deduced amino acid sequences of the β1 domain coded by exon 2 revealed 6 synonymous mutations and 27 nonsynonymous substitutions at the 33 disparate sites.

对B-LBⅡ等位基因第二外显子所编码的B-LBⅡ分子β1结构域氨基酸序列比对发现，31个B-LBⅡ新等位基因属于26个等位基因主型；在β1结构域氨基酸序列的33个变异位点上，存在6个同义替换和27个错义替换。

Second, residues in the reactive site of the inhibitor were replaced by the consensus substrate recognition sequence of furin, namely, Arg at P_1, Lys at P_2, Arg at P_4 and Arg at P_6. In addition, the P_7 residue Asp was substituted with Ala to avoid possible electrostatic interference with furin inhibition. Finally, the extra N and C terminal residues beyond the doubly conjugated disulfide loops were further truncated. However, all resultant synthetic peptides were found to be temporary inhibitors of furin and kexin during a prolonged incubation, with the scissile peptide bond between P1 and P'1 cleaved to different extents by the enzymes.

高活性、低分子量的furin酶抑制剂有可能发展成为新型的抗细菌内毒素和抗病毒感染的药物，我们以绿豆胰蛋白酶抑制剂Lys片段长链22肽为模板，设计了一系列能抑制furin和kexin活性的突变体，采用如下三种方法逐步优化：一、去除Lys片段长链三对二硫键中的一对，用Ser替换Cys，减少可能存在的二硫键错误配对；二、抑制剂的活性中心根据furin底物的专一性逐步改变，即P1、P2、P4和P6位分别变为Arg、Lys、Arg和Arg，同时为了避免P7 Asp和P6 Arg之间可能存在的相互作用，将P7位Asp替换为Ala；三、将两对二硫键形成的双环的外面5个氨基酸残基去除。

When a string is defined using double quotes, any references to variables within that string will automatically be replaced with their respective values, whereas unparsed strings will replace nothing.

当一个文本串被使用双引号定义，任何在文本串内的变量引用将自动地被它们各自的值替换掉，相反对于非解析的文本串将不做任何替换。

"Against all liabilities, claims, demands, proceedings, costs or expenses of whatsoeer nature which may be made or brought against or incurred by the lessor by reason of any loss, injury, death or damage caused or chaimed to be caused to any person or of any loss of or damage to property occasioned by or arising or claimed to be occasioned or to arise directly or indirectly out of the manufacture, deliery, presence, possession, proision, operation, use, instalment, remoal, transportation, replacement or repair of the goods and whether arising or claimed to arise out of defects in the goods or by reason of the goods infringing or being claimed to infringe any patent, copyright, confidential information of other intellectual property rights."

&对出租人可能提出的或出租人可能招致的，由于以下原因的所有责任、索赔、要求、诉讼、费用或任何性质的开支，其原因或者是直接或间接因货物的制造、送交、存在、占有、供应、操作、使用、安装、移动、运输、替换或修理，不论是否由于或据称由于货物有缺陷，而对任何人造成或据称造成的任何损失、伤害、死亡或损害，或对财产造成或引起或据称造成或引起的任何灭失或损害，或者是因货物侵犯或据称侵犯任何专利、版权、机密情报或其他智力产权&。这里保证补偿的是&……一切责任、索赔、要求、诉讼、费用或任何性质的开支&，其原因有两种情况，一是租赁货物对人或财产造成损害，二是租赁货物侵犯智力产权。关于第一种情况，合同不厌其烦地列举&直接或间接因货物的制造、送交、存在、占有、供应、操作、使用、安装、移动、运输、替换或修理，不论是否由于或据称由于货物有缺陷……&。这段话中多次提到&造成&、&引起&，但都要加上&或据称&，成为&造成或据称造成&、&引起或据称引起&。

The algorithm meliorates the classification accuracy of the samples of metamorphic characteristic words including Pinyin substitution, homophone substitution and symbols insertion,etc.

算法提高了对于含有拼音替换、同音字替换、符号插入等变形特征词样本的分类准确率。

With regard to traditional replace policy in buffer, the thesis propounds an improved adaptive LRU replace policy on basis of researches on merits and faults of various algorithms.

研究各传统缓冲区替换算法的优缺点，提出一种改进的自适应LRU替换算法。

Cabinet refacing, cabinet door replacements, or paint offer options for consumers who cannot afford to replace complete cabinets.

重修表面，橱门替换或者油漆不可能替换完全内阁的消费者的内阁提议选择。

If the result part of the expression is repeated, you can replace the repeats one at a time.

如果要替换的表达式的这一部分重复出现，你可以每次替换一个。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。