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Because of increased awareness of the activity and toxicity of current drugs, the threshold for initiation of therapy has shifted to a later time in the course of HIV disease. However, the optimal time to initiate therapy remains imprecisely defined.

随着对当前新药活性和毒性了解的不断增加,学术界比较认可抗逆转录病毒治疗开始的时间应该放在艾滋病患者病程的较晚期这一共识,但治疗开始的最佳时间尚未得到精确测定。

Nancy:This was a style around the same time as Post Impressionism, in the late 1800s.

Victor:它和后印象派几乎出现在同一时代,在 19 世纪晚期

In her middle and late periods, Impressionistic harmonies were found.

到了中晚期,受印象乐派影响所做的实验性和声进行愈多,半音阶的使用减少。

Some people say workers in mid career or later won't have time to recoup the cost of an advanced degree .

有人说在职业生涯中期或晚期的工作人士没有时间来享受更高的学位带来的益处。

TITe is a sharp contrast in with his earlier and in a while works.

他的早期作品和晚期作品截然不相同。

In addition, the late hemorrhoids, can cause anus repeatedly about muscle relaxation and expansion, cause anus margin secretion, often damp unclean and eczema itching, serious when still can cause the pain and wipe urticant painful, hemorrhoids bleeding can also cause anemia, dizziness, languid, energy, inappetence, defecate drying is the common symptoms of anemia.

此外,晚期内痔反复脱出,可引起肛门扩约肌松驰和分泌物增多,致使肛缘常潮湿不洁,出现瘙痒和湿疹,严重时还可引起擦摩痛和痒痛,内痔出血还可引起贫血,头晕、倦怠乏力、精力不佳、食欲不振、大便干燥等是贫血的常见症状。

His next play, Brand (1865), was to bring him the critical acclaim he sought, along with a measure of financial success, as was his next play, Peer Gynt (1867), to which Edvard Grieg famously composed the incidental music .

重要劇作有《青年同盟》、《社會支柱》、《玩偶之家》、《群鬼》、《人民公敵》等。1891年,易卜生六十三歲時回到久別的祖國,在奧斯陸度晚年,他晚期的創作,不像中期那樣熱情、犀利,顯得冷峻、深邃,轉向心理描寫和精神分析,也有悲觀情緒和象徵主義色彩,作品有《野鴨》、《建築師》等。

Recent series reported increasing incidence of esophageal and cardial cancers with prognosis still severe in spite of surgical progress. The late diagnosis reduces the chance of radical surgery; on the other hand about 80-90% of patients develop local or distant recurrence.

最近一系列的报道表明食管癌和贲门癌的发生率不断增长,不论外科进展如何,但其预后是差的,晚期病例减少了外科的选择,另一方面,大约有80-90%的病人发生局部或远处转移。

For locally advanced NSCLC patients, an individulized treatment plan made by evidence-based methods not only can inprove the treatment efficacy but also can lead both of doctors and patients to assume the indeterminateness of medicine.

采用循证治疗方法,为晚期非小细胞肺癌患者确定合理的治疗方案,不仅可有效提高治疗效果,同时有利于引导医患双方共同承担医疗不确定性的风险。

The results indicated that the content of cytosolic CaM in cells treated with exogenous Ca2+ has increased indistinctively, while fluorescence intensity in cells treated with TFP decreased. So we believed that exogenous Ca2+ has little effect on the expression of CaM. High concentration of TFP can enter yeast cells and combine to CaM to make it inactive, which is the reason that TFP restrain the growth of yeast cells. 5mmol/L EGTA could completely arrest the cell proliferation of MFP7 after 28h, when the fluorescence intensity in cells wasobviously increased with flow cytometry and LSCM.

被较高浓度TFP处理过的MFP7胞内荧光强度则相对较弱,推测是因为TFP进入胞内与CaM结合从而使其失活,这也是高浓度TFP抑制酵母细胞增殖的原因。5mmol/L EGTA处理28h左右后,酵母细胞的生长被抑制在G1晚期,此时通过细胞流式法和在激光扫描共聚焦显微镜下观察到胞内荧光强度显著高于对照,说明CaM的表达水平在G1后期开始上升;回加10mmol/L Ca~(2+)处理24h后,细胞开始恢复生长,细胞流式法测定胞内荧光强度有所下降,表明多数细胞完成G1/S转换,进入生长对数期。

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We have no common name for a mime of Sophron or Xenarchus and a Socratic Conversation; and we should still be without one even if the imitation in the two instances were in trimeters or elegiacs or some other kind of verse--though it is the way with people to tack on 'poet' to the name of a metre, and talk of elegiac-poets and epic-poets, thinking that they call them poets not by reason of the imitative nature of their work, but indiscriminately by reason of the metre they write in.

索夫农 、森那库斯和苏格拉底式的对话采用的模仿没有一个公共的名称;三音步诗、挽歌体或其他类型的诗的模仿也没有——人们把&诗人&这一名词和格律名称结合到一起,称之为挽歌体诗人或者史诗诗人,他们被称为诗人,似乎只是因为遵守格律写作,而非他们作品的模仿本质。

The relationship between communicative competence and grammar teaching should be that of the ends and the means.

交际能力和语法的关系应该是目标与途径的关系。

This is not paper type of business,it's people business,with such huge money involved.

这不是纸上谈兵式的交易,这是人与人的业务,而且涉及金额巨大。