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星形细胞瘤

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Objective To study the significance of IL-6 mRNA expression in astrocytomas and its relation with pathological grade in astrocytoma.

目的 研究IL-6mRNA在星形细胞瘤中的表达及其与星形细胞瘤病理分级的关系。

The mean tumor volume at the time of GKS was 2.5 cm3. In 10 cases a tumor specimen was obtained either by open surgery or stereotactic biopsy, securing the diagnosis of pilocytic astrocytoma in five patients and nonpilocytic astrocytoma in five others.

开始GKS治疗时的平均体积是2.5 cm3.10例的肿瘤标本通过开放手术或立体定向的活检获得,得出的诊断是:5例毛细胞性星形细胞瘤,5例为非毛细胞性星形细胞瘤

The mean tumor olume at the time of GKS was 2.5 cm3. In 10 cases a tumor specimen was obtained either by open surgery or stereotactic biopsy, securing the diagnosis of pilocytic astrocytoma in fie patients and nonpilocytic astrocytoma in fie others.

开始GKS治疗时的平均体积是2.5 cm3.10例的肿瘤标本通过开放手术或立体定向的活检获得,得出的诊断是:5例毛细胞性星形细胞瘤,5例为非毛细胞性星形细胞瘤

Results Ependymoma and astrocytoma are the most common spinal cord gliomas.The rate of radical resection was higher in ependymoma than in astrocytoma cases.

结果脊髓胶质瘤以室管膜瘤和星形细胞瘤为主,其中以室管膜瘤居多而且手术全切率较高,星形细胞瘤手术全切率较低。

Results 1. The expression of P53, KI-67, hTERT and ToPo II a protein was higher in astrocytoma than that in nomal brain tissue, the expression of these markers was obversely correlated to the grade of astrocytoma (P.05). The expression of Fas was higher in astrocytoma than that in nomal brain tissue, on the contrary, expression of P16 was lower in astrocytoma than that in nomal brain tissue.

结果 1、星形细胞瘤中P53、KI-67、hTERT与ToPoⅡα蛋白表达阳性率高于正常脑组织,P53、KI-67、hTERT与ToPoⅡα蛋白表达与星形细胞瘤的病理组织学分级呈显著正相关(P.05);Fas蛋白在星形细胞瘤中的表达高于正常脑组织,而P16蛋白表达低于正常脑组织,Fas、P16蛋白表达与组织学分级无显著相关性。

Results: the findings on ct and mri were as follows: 57 cases of oligodendroglioma, 15 cases of ganglioglioma , 5 cases of dysembryoplastic neuroepithelial tumor , 3 cases of pleomorphic xanthoastrocytoma .conclusion:the images on ct and mri of cerebra peripheral tumor occur some characters , so ct and mri were certain worth on the diagnose and differentiate diagnose of cerebra peripheral tumor.

结果:少枝胶质瘤47例,间变性少枝胶质瘤10例,节细胞胶质瘤15例,胚胎发育不良性神经上皮瘤5例,多形黄色细胞瘤3例。结论:脑浅表肿瘤存在影像特征,ct及mri对其诊断有一定的价值。少枝胶质细胞瘤;节细胞肿瘤;胚胎发育不良性神经上皮瘤;多形性黄色星形细胞瘤;ct;mri

The distribution of PA I-1 protein was mainly in tumor cells of high-grade astrocytomas, particularly abundant in areas of vascular proliferation and in tumor cells surrounding necr otic foci, whereas it was only weekly expressed in low-grade astrocytomas.

PAI-1蛋白主要分布在高级别星形细胞瘤的瘤细胞和内皮细胞,尤以血管增殖部位和坏死灶周围较为显著,低级别星形细胞瘤呈低表达。

Results 5 cases of ependymocytoma, 3 cases of astrocytoma, 1 medulloblastoma hemangioblastoma in 10 cases of intra-medullary tumor; 36 cases of neurogenic tumor, 11 cases of spinal meningioma in 47 cases of subdural extramedullary tumor; 2 cases of neurogenic tumor strided over scleromeninx;2 cases of extradural metastatic tumor, 1 cestodiasis, 2 cases of epidural hematoma, which were mistaken for hemangioma before surgical operation and 1 vascular malformation in 4 cases of intraspinal nontumorous occupying lesion.

结果:10例髓内肿瘤中,室管膜瘤5例;星形细胞瘤3例;血管母细胞瘤1例;成神经管细胞瘤1例。47例脊髓外硬膜下肿瘤中,神经源性肿瘤36例;脊膜瘤11例。2例跨硬膜内外生长的神经源性肿瘤2例。硬膜外的转移瘤2例。4例椎管内非肿瘤性占位性病变中,椎管内绦虫病1例;硬膜外血肿2例,术前误为血管瘤;血管畸形1例。

Stupp R, Mason WP, van den Bent MJ, et al: Concomitant and adjuvant temozolomide and radiotherapy for newly diagnosed glioblastoma multiforme: conclusive results of a randomized phase III trial by the EORTC Brain and RT Groups and YCIC Clinical Trials Group.

星形细胞瘤则为5~10年。毛细胞性星形细胞瘤则为正常寿命。许多脑膜瘤[1]和垂体腺瘤[2]的病人一直没有症状。这些肿瘤被偶然发现,或在死于其它疾病后尸检发现肿瘤。

The results showed that among the parameters clinically used by the pathologists in the diagnoses of astrocytomas,tumor size,giant tumor cell number/high power fieldand mitoses/30HPF were closely related to the DI and PI of the...

结果发现,病理学工作者在星形胶质细胞瘤诊断时所依据的各种参数中,肿瘤体积、每高倍视野瘤巨细胞数和每30个高倍视野中核分裂数与星形细胞瘤DI及PI密切相关,肿瘤平均直径越大、瘤巨细胞数和核分裂数越多,则DI和PI值越高。

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