明显特征

DCs acquired by our reformed methods express both CD83 and CD 14 molecules highly, and have a higher density than other domestic reports. The higher TNF in DCs culture medium of HC patient suggests DCs in patient still have antigen presenting ability and by optimization the culture medium would improve its presenting ability and have a potential value in design and application individual vaccine. Although antigens pulsed DCs have a decrescent antigen presenting ability but BCG HSP70 could induce its mature and improve its presenting ability. Suggests BCG HSP70 would be a useful mature inducer. Lymphocytes primed by DCs based HC vaccine have the specific cytotoxicity against HCC lines. The CTL after freezing and anabiotic could prophylaxis and therapy HC xenograft on nude mouse. The results also suggests that CD4〓 lymphocytes play a important role in HC with a good differentiation and would be useful in treatment this kind of HC. After being activated by Peptide LLNQHACAV of hAFP and apoptotic HCCs pulsed DCs respectively, the culture medium of activated lymphocytes both contains a high level Th1 cytokines IL-12 and TNF. Primed lymphocytes appeared a characteristic of NK cells. DCs not only inhibited the growth of human HCC and other cancer cells in vitro but also prevented the growth of HC xenograft on nude mouse in vivo. There are at least three kinds of mechanism playing important role in DC based vaccine ,there are inhibition of DCs, HC specific CTL and cytokines pathway.

诱导出的DC共同表达CD83和CD14分子，CD83分子表达明显高于国内报道；肝癌患者DC培养上清中TNF水平高于健康人，提示肝癌患者DC仍具一定的抗原呈递能力，适当调控可使其行使APC功能，以期在肝癌个体化疫苗中发挥作用；DC负载肝癌可溶性抗原后，抗原呈递能力降低，BCG HSP70可促进DC成熟，增加其抗原呈递能力，预示BCG HSP70有可能成为促进DC活化和成熟的另一重要分子；肝癌DC疫苗在体外诱导肝癌特异性淋巴细胞，活化的淋巴细胞在体外对肝癌细胞的杀伤以特异性CTL为主，同时分泌较高水平Th1型细胞因子IL-12和TNF，并抑制4种肝癌细胞生长；冷冻复苏后的肝癌特异性淋巴细胞可以预防和抑制人肝癌裸鼠皮下移植瘤，提示DC负载肝癌可溶性抗原后诱发的MHC-Ⅱ类限制性CD4〓T细胞有可能在分化程度高的肝癌治疗中发挥作用；用DC和HLA-A2〓DC分别负载凋亡肝癌细胞和hAFP218-226位LLNQHACAV HLA-A2限制性九肽，在体外诱导肝癌特异性淋巴细胞，活化后的CTL细胞分泌较高水平的Th1型细胞因子IL-12和TNF，并具较强杀伤活性，此CTL同时具备NK细胞特征；DC对肿瘤细胞的抑制作用可能是通过吞噬实现的，Fas-L在DC抑制中也起一定作用；DC对人肝癌裸鼠皮下移植瘤的抑制率为97％；在肝癌DC疫苗的作用中，至少联合3种以上机制，即通过DC的直接作用、肝癌特异性CTL和细胞因子途径直接或间接地杀伤和抑制肝癌细胞。

Creep cracks seem always to initiate at inherent casting pores and slowly propa-gate anisotropically along the (001) planes, perpendecular to axis of stress applied, upto the final fast fracture. Creep cracks can also nucleate at fractured carbides or at in-terfaces between carbides and matrix in the alloys containing more carbon.

结果表明：单晶的蠕变断裂具有明显的晶体学特征，蠕变裂纹总是从已有的铸造的显微疏松处萌生；对于含碳量较高的材料，碳化物及其与基体的界面也是裂纹萌生的有利位置；这些已萌生的裂纹在外加应力轴垂直的(001)面上各向异性地扩展，直到由于承载截面的逐渐减小而导致最终破坏。

The uptake of anthropogenic CO2 by the Ocean is studied.

海洋人为CO2的吸收有明显的纬度特征。

The inflammation reaction hyperplactic stage and lymphatic nodular stage are of nonspecific morphological changes and should be diagnosed with the help of positive tuberculin test and obvious increase of adenosine deaninase ; tuberculous nodular stage has a great number of epithelioid cells,and Langhans cells,caseous necrosis stage is characterized by a great deal of necrotic tissue and debris,a small number of fragmented epithelioid cells,and mainly by antiacid bacteria fibrinous hyperplastic stage is featured by a few fibrous tissue,cells and mucous oweing to hardness to get puncture,which neans tuberculous restoration,and scar formation.

炎性增殖反应期非特异性形态学变化，需要结合结核抗体阳性和腺苷酸脱氨酶明显增高有助于诊断，结核结节期主要可有较类上皮样细胞及郎罕氏细胞；而干酪样脓样坏死主要见量坏死组织及碎屑、少残碎不全类上皮样细胞，此期主要能查到抗酸菌特点；纤维增殖期，抽出物难取，仅见少数纤维组织、纤维细胞和黏液间质为其特征，提示结核恢复、瘢痕形成所致。

The inflammation reaction hyperplactic stage and lymphatic nodular stage are of nonspecific morphological changes and should be diagnosed with the help of positive tuberculin test and obvious increase of adenosine deaninase ; tuberculous nodular stage has a great number of epithelioid cells,and Langhans cells, caseous necrosis stage is characterized by a great deal of necrotic tissue and debris,a small number of fragmented epithelioid cells, and mainly by antiacid bacteria fibrinous hyperplastic stage is featured by a few fibrous tissue, cells and mucous oweing to hardness to get puncture, which neans tuberculous restoration,and scar formation.

炎性增殖反应期非特异性形态学变化，需要结合结核抗体阳性和腺苷酸脱氨酶明显增高有助于诊断，结核结节期主要可有较多类上皮样细胞及郎罕氏细胞；而干酪样脓样坏死主要见大量坏死组织及碎屑、少数残碎不全类上皮样细胞，此期主要能查到抗酸菌为特点；纤维增殖期，抽出物难取，仅见少数纤维组织、纤维细胞和黏液间质为其特征，提示结核恢复、瘢痕形成所致。

The inflammation reaction hyperplactic stage and lymphatic nodular stage are of nonspecific morphological changes and should be diagnosed with the help of positive tuberculin test and obvious increase of adenosine deaninase ; tuberculous nodular stage has a great number of epithelioid cells,and Langhans cells, caseous necrosis stage is characterized by a great deal of necrotic tissue and debris,a small number of fragmented epithelioid cells, and mainly by antiacid bacteria fibrinous hyperplastic stage is featured by a few fibrous tissue, cells and mucous oweing to hardness to get puncture, neans tuberculous restoration,and scar formation.

结核初期-炎性增殖期60例，占5.5%；结核早期-淋巴结节期130例，占11.9%；结核中期-结核性结节期有590例，占54.1%；结核晚期-干酪样脓样坏死期有280例，占25.7%；结核恢复期-纤维素增殖期30例，占2.8%。炎性增殖反应期非特异性形态学变化，需要结合结核抗体阳性和腺苷酸脱氨酶明显增高有助于诊断，结核结节期主要可有较多类上皮样细胞及郎罕氏细胞；而干酪样脓样坏死主要见大量坏死组织及碎屑、少数残碎不全类上皮样细胞，此期主要能查到抗酸菌为特点；纤维增殖期，抽出物难取，仅见少数纤维组织、纤维细胞和黏液间质为其特征，提示结核恢复、瘢痕形成所致。

After the carboxymethylation,the solubility of pachyman in the water was significantly increased,its β-D-glucan characteristic absorption peak at 890 cm-1 became weak obviously,and its methylene vibration absorption peak and CO antisymmetrical stretch vibration absorption peak appeared at 1 333 and 1 606 cm-1 respectively,which indicated that the carboxymethylation succeeded.The analysis of AFM results showed that CMP molecules existed in different morphology under different solution conditions,and that the concentration,ionic strength and solvent physical chemistry characteristics of polysaccharide solution had effects on the CMP chains conformation and the action mode between different molecular chains.The phenomena were considered to be related to hydrogen bond association and intramolecular and intermolecular electrostatic interactions of CMP.

结果表明：经过羧甲基修饰，茯苓多糖在水中的溶解性显著增加，890 cm-1 处的β-D-葡聚糖特征吸收峰明显减弱，1 333 cm-1 处出现次甲基振动吸收峰，1 606 cm-1 处出现〖JG(〗C〖ZJLX，Y〗O〖JG)〗非对称伸缩振动吸收峰，表明羧甲基化成功；原子力显微镜分析表明：在不同溶液条件下，CMP分子以不同形态存在，多糖溶液的浓度、离子强度及溶剂的物化特性均能对CMP的分子链构象及链间相互作用形式产生影响，推测可能与CMP分子内、分子间的氢键缔合及静电作用有关，CMP分子与云母基底间的吸附及静电作用也会对CMP的分子链构象及图像质量产生影响。

This dissertation first introduced actuality of farmer specialty cooperation of Taizhou city in briefly and analyzed its characteristics from associator relation, organization structure, stock structure , benefit return and other sides. Indicated that these organizations have remarkable city characteristic of Taizhou; Sumed up main operative methodof Taizhou to develop farmer specialty cooperation as follows:(1) increased policy support, improved develop environment;(2) established service flat roof;(3) reinforced work lead, accelerated criterion development;(4) intensified organization impulse,formed develop main.

本文首先简要介绍了台州市农民专业合作社发展现状；从社员关系、组织结构、股权结构、利益返还和表权方式等方面分析了台州市农民专业合作社的组织特色，指出这些组织特色具有明显的台州地域特征；总结了台州市发展农民专业合作社的主要做法：(1)加大政策扶持，改善发展环境；(2)建服务平台，培植典型示范；(3)加强工作指导，促进规范发展；(4)强化组织推动，形成发展全力。

The discrepancy between MASSR and behavioral threshold is another audiometric feature of AN.

多频听觉稳态反应阈同纯音听阈之间明显的不一致性是听神经病的又一项较为显著的听力学检查特征。

The activated or leached process and their influence elements are studied by 1DREACT software package of coupled mass/heat transfer and chemical reaction dynamics of water-rock interaction, according to the geological and geochemical characters of fine disseminated gold deposits.(1) Water-rock reaction time is not the important influence element of activating gold;(2) At first, activating capability of hydrothermal solution increases with the increasing of total sulfur activity; after lga〓≥-4, the content of activated gold in solution is mainly related to original content of gold in wall rock, and does not visibly dependent on total sulfur activity.(3) It is a complicated nonlinear process of influence of activating gold capacity of hydrothermal solution with the change of temperature, in general, 220 ℃ is most favorable to gold activation.(4) The influence of oxygen fugacity on gold activation has a multiple functions coupling nonlinear effect, in general, Igfo〓=-41 is most favorable to gold activation.(5) Solubility of gold in fluid decreases with the increasing of velocity of flow, the product of velocity and aurous solubility reaches maximum when velocity is 0.2～0.5m〓m〓. yr〓, i. e. this scope of velocity is most favorable to gold activation.

利用1DREACT水-岩相互作用反应-输运耦合动力学软件包，根据微细浸染型金矿床地质地球化学特征，计算机模拟研究了金的活化、浸取过程及其影响因素，发现：(1)金活化过程中水-岩反应时间不是其主要制约因素；(2)热液对金的活化能力开始随总硫活度的增高而增高，当lg a〓≥-4后，热液中活化金的含量将主要与围岩中金的初始丰度有关，而对总硫活度无明显依赖关系；(3)温度对热液浸金能力的影响是一个复杂的非线性过程，总体而言，220℃最有利于金的活化；(4)氧逸度对金活化的影响呈现出一种多因素叠加的非线性效应，总体而言，lgfo〓＝-41最有利于金的活化与浸取；(5)流体中金的浓度随流体流速的加快而降低，流速与金浓度的乘积在流速为0.2～0.5m〓m〓。yr〓时达到极大，即0.2～0.5m〓m〓。yr〓的流速范围最有利于本类矿床的金的活化。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。