明显

By using Morris Maze task,The results indicated the learning and memory impairment was continuously maintained by MA-induced neurotoxity,PF_(11) significantly antagonized the learning and memory impairment by MA-induced neurotoxicity, Motor incoordination was studied by using the rotating rod method in mice,PF_(11) markedly alleviated the injury induced by MA.using HPLC-ECD,there were markedly decrease the contents of DA,DOPAC,HVA and 5-HIAA,PF_(11) markedly antagonised decrease of DA in MA-induced neurotoxicity.

在Morris水迷宫空间辨别性学习记忆实验中，甲基苯丙胺中毒小鼠找到平台的潜伏期明显延长，PF_(11)沈阳药科大学硕士学位论文中文摘要能显著缩短延长的潜伏期。转棒实验表明，甲基苯丙胺中毒小鼠运动协调性显著降低，而PF；；能桔抗小鼠运动协调性的降低。甲基苯丙胺中毒小鼠大脑内多巴胺及其代谢产物DOPAC、HVA含量明显降低，另外，5一羟色胺的代谢产物5－HIAA明显降低，而PF；；与甲基苯丙胺联合给药小鼠大脑内DA、HVA的含量显著升高。这些结果提示PF；通过影响多巴胺神经系统而桔抗甲基苯丙胺神经毒性的作用。

Glucose load can significantly lower blood glucose in mice, but also significantly against adrenaline-induced increase in blood glucose response in mice, and it can obviously confrontation Phenformin mice caused by hypoglycemia.

可使葡萄糖负荷的小鼠血糖明显降低，也能明显对抗肾上腺素引起的小鼠血糖升高反应，而且它还能明显对抗苯乙双胍引起的小鼠实验性低血糖。

Results:Osteoblasts has the ability of transmembrane transport of metformin. The transport of metformin could be saturable with time and drug concentration adding;a certain range of temperature and pH can promote the transport of metformin;The transport of metformin was inhibited by cimetidine and phenformin,but promoted by verapamil;Oct1 but no Oct2 was expressed extensively in cell membrane and cytoplasm of osteoblasts;The protein level of Oct1 can be up-regulated by metformin with different drug concentrations and times,but no obvious differentces from each group.

结果：二甲双胍能够在成骨细胞上进行跨膜转运，且随着转运时间和药物浓度的增加而增加，并可达到饱和；一定范围内提高温度和pH值可以促进二甲双胍的转运；西米替丁和苯乙双胍对二甲双胍转运有明显抑制作用，而维拉帕米则对转运有明显的促进作用；Oct1广泛表达在成骨细胞的胞膜及胞浆中，而Oct2无表达；二甲双胍在不同浓度及不同给药时间均能够上调Oct1的表达，但各组间无明显差别。

Antiviral 〔HBV, HCV and HIV〕, and anti-inflammatory 〔of Shigella dysenteriae, Bacillus anthracis, a, b-type melting Streptococcus pneumoniae, Staphylococcus aureus, E. coli, salmonella have both antibacterial antibacterial activity〕,〔Jiangtang glucose load can significantly lower blood glucose in mice, but also significantly against adrenaline-induced increase in blood glucose response in mice, and it can obviously confrontation Phenformin mice caused by hypoglycemia .

抗病毒〔 HBV ， HCV 与 HIV 〕，，抗炎〔对志贺氏痢疾杆菌，炭疽杆菌， a 、 b 型溶链球菌肺炎双球菌，金黄色球菌，大肠杆菌、沙门氏菌均有抗菌均有抗菌作用〕，降糖〔可使葡萄糖负荷的小鼠血糖明显降低，也能明显对抗肾上腺素引起的小鼠血糖升高反应，而且它还能明显对抗苯乙双胍引起的小鼠实验性低血糖。

The results showed that a reduction of glutamate in brain homogenates and changes of enkephalins in 3 brain regions,without changes in other regions.

结果 二甲苯使染毒大鼠脑组织兴奋性氨基酸谷氨酸含量明显下降，部分脑区β-内啡肽和亮啡肽含量与对照组比较有明显改变，而另一些脑区则无明显变化。

These enzymatic haemostatic agents can be used to antagonize the side effect of hirudin. We take the batraxobin as an example to illustrate that the enzymatic haemostatic can antagonizes hirudin. Agglutination reaction occurred after the tubes containing hirudin were added with batroxobin , i.e., batroxobin can antagonize hirudin. In a canine model,, the reduction extent of TT and APTT in the test group was larger than that in the control group; the bleeding time was decreased obviously and it was shorter in the experimental group than in the control group at lh, 2h and 3h after hirudin injection, indicating batroxobin can antagonize the bleeding side effects of hirudin.

以巴曲停为例，加入巴曲停的水蛙素抗凝试管内又可发生凝集反应，而未加入巴曲停的试管内不发生凝集反应；犬动物模型显示，水蛙素实验组TT值、 APTT值明显低于水蛙素对照组，犬给予巴曲停后出血时间明显缩短，出血时间在滴注水蛙素后lh、2h、3h明显短于对照组(P.05)，说明巴曲停有拮抗水蛙素抗凝血的作用。

The asymmetry of sidebands can be observed in two aspects:on the one hand,the asymmetry of the power between the positive and the negative order numbers is obvious,which can be observed that the intensity of the positive second order is higher 14.28 dBm than that of the negative same order;on the other hand,the sideband asymmetry numbers from the positive to the negative orders are also obvious,the number of the positive orders is more 5 numbers than that of the negative.

实验结果表明，光谱不对称性主要存在两方面的明显特点：1强度不对称性，最明显时正二级的强度比负二级的强度高14.28 dBm ；2数量不对称性，最明显时正级数量要比负级数量多5个。

Western blot showed that increased TGF-β1, p-Smad2/3 and phosphorylation of P-38 MAPK proteines in DCM were repressed with treatment of astragaloside, while Smad7 showed no evident variations. Collagen I, the target gene of TGF-β1/Smad and TGF-β1/p38MAPK signal transduction pathway, was cut down in group Astr.

蛋白定量检测结果显示：黄芪甲甙降低TGF-β1、p-Smad2/3及Smad4的表达，以Smad4表达降低最明显，对Smad7的表达无明显作用；抑制p38MAPK的磷酸化活动；Ⅰ型胶原是TGF-β1/Smad和TGF-β1/p38MAPK信号通路的靶基因，黄芪甲甙明显降低Ⅰ型胶原mRNA的表达。

RESULTS:Under room temperature,after YZH mixed with Ringer's solution,the pH...

结果 ：在室温条件下，茵栀黄注射液与林格配伍后，其pH值变化明显，并有大量白点产生；与GNS配伍后，24h内其pH值及黄芩苷的含量均无明显变化；与其它3种输液配伍后，在2h内其pH值及黄芩苷的含量均无明显变化，但与NS配伍后不溶性微粒数不符合规定。

Kidney structure, the activities of ALP, MDH, SDH and ATPase were unaffected in EILST rats. But in KYD rats, the structure of the kidney injured and the activities of ALP, MDH, SDH and ATPase decreased. And the PK activity decrased in all rats as well.

运动性低血睾酮&对肾脏的结构、ALP、MDH、SDH和ATP酶活性没有明显影响，&肾阳虚&则破坏肾脏的结构，明显降低ALP、MDH、SDH和ATP酶的活性，两种状态都使肾脏PK活性明显降低。&

I am accused of being overreligious," she said in her quiet, frank manner,"but that does not prevent me thinking the children very cruel who obstinately commit such suicide.""

客人们在卡罗利娜·埃凯家里，举止就文雅一些，因为卡罗利娜的母亲治家很严厉。

Designed by French fashion house Herm è s, this elegant uniform was manufactured in our home, Hong Kong, and was the first without a hat.

由著名品牌 Herm è s 设计，这件高贵的制服是香港本土制造，是我们第一套不配帽子的制服。