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The study show that the frozen earth in this area is mainly silty clay. The content of the dissolvable solt is relative high,which is 12.01%, and the main salinity is NaCL and KCL. The research also revealed that frozen intensity would ascend jumpily when the water contend in the soil reached its optimization( 10.61%) and kept rising,and this phenomena got more obvious with the decrease of the temperature. Between 0C and 10C, the frozen intensity vared very obviously, when the temperature is under -10C, the variety of frozen intensity got gently, and the change is not obvious. The frozen strength was influenced by the solution thickness in the soil hole.when the thickness increased, the frozen intensity decreased.

研究表明:那曲河地区冻土区冻土主要为颗粒较细小的粉质粘土:土样易溶盐含量较高,为12.01%,主要盐分为氯化钠NaCL和氯化钾KCL;该地区冻土土内水分达到最优含水率10.61%并继续增大时,冻结强度有个跳跃式的上升,这种现象随着温度的降低而愈明显;由0℃到-10℃时,冻结强度变化十分明显,温度下降到-10℃以后,冻结强度变化趋于平缓,变化不甚明显;冻结强度受土样孔隙中盐溶液浓度的影响,盐溶液浓度增加,冻结强度减小。

Nerve ton e deterioration; vagal ton e withdr awal,sympathetic ton in creasingand C ardiac v agal ton e in creasing and

患者存在自主神经调节异常,SDNN 和HF 明显降低,LF 降低不明显,LF/HF 比值明显增加;替米少坦治疗3 月后迷走神经活性明

On the other hand, in IBS model groups, the changes of ethology was most significant in the 0.8 ml group, and the ethology was no difference among the 0.8 ml, 1.2 ml, 1.4 ml and 1.5 ml groups, the electric activity of external oblique muscle of abdomen have no obvious change in the normal control group and air bladder control group.

实验组IBS大鼠,0.6ml时即出现明显的痛行为学表现(痛行为评分为51.55±7.57至53.23±5.46)与单纯给与气囊之对照组的痛行为(17.16±3.12至19.23±4.54)相比有显著性差异0.8ml组的痛行为学最为明显(痛行为评分为93.53±4.07至90.33±4.79),基本上达到痛行为学反应的高峰,与0.6ml组相比,存在显著性差异,而与1.0m组及以后各组相比无明显差异。

In order to study the relation of cytochrome P-450 with the protective action of SY-801 and SY-640 against 〓-induced UDS and 3H-BP binding to nuclear DNA, the effects of SY-801 and SY-640 on liver microsomal cytochrome P-450 were studied in mice. The results indicated that the liver microsomal cytochrome P-450 concentration and aminopyrine demethylase activity were significantly increased in mice pretreated with SY-801 150mg/kg or SY-640 150 mg/kg once daily for three days.

本实验进而观察了SY-801对小鼠肝微粒体细胞色素P-450酶系的影响,结果表明SY-801和SY-640体内连续给药3天,可诱导小鼠肝微粒体细胞色素P-450含量明显增加,同时氨基比林脱甲基酶活性亦明显增加;给药1次2小时内二者均可抑制氨基比林脱甲基酶活性,而对肝微粒体细胞色素P-450含量则无明显影响。

Results The body weight, visceral fat and body weight ration, as well as the levels of blood glucose, insulin, triglyceride, total cholesterol, LDL, and total FFA, were significantly lower in high fat-fed group than in control group (P.01). The aortic tunica intima was intact, the number of foam cells was decreased, and inflammatory cells infiltrated into the med-intima smooth muscle of the n-3 PUFA group. However, with no such changes were observed in control and n-3 PUFAs groups.

结果 n-3脂肪酸组大鼠体重第1~11周均明显降低,空腹血糖、血清胰岛素、TG、TC、LDL-C、总FFA和内脏脂肪占体重百分比均明显低于HF组,HDL-C则明显高于HF组,与对照组无明显差别;n-3脂肪酸组大鼠主动脉主动脉内膜完整无内皮细胞脱落现象,内膜下泡沫细胞及炎细胞浸润减少,内膜的NF-κB呈弱阳性表达,IκBα呈阳性表达,ICAM-1和MCP-1均呈阴性或弱阳性表达。

The aortic tunica intima was intact, the number of foam cells was decreased, and inflammatory cells infiltrated into the med-intima smooth muscle of the n-3 PUFA group. However, with no such changes were observed in control and n-3 PUFAs groups. Little or no expression of NF-κB, ICAM-1 and MCP-1, and a high expression level of IκBα were detected in aortic tunica intima of the n-3 PUFA and control groups, while high expression levels of NF-κB, ICAM-1 and MCP-1, and little expression of IκBα were detected in aortic tunica intima of the high fat-fed group.

结果 n-3脂肪酸组大鼠体重第1~11周均明显降低,空腹血糖、血清胰岛素、TG、TC、LDL-C、总FFA和内脏脂肪占体重百分比均明显低于HF组,HDL-C则明显高于HF组,与对照组无明显差别;n-3脂肪酸组大鼠主动脉主动脉内膜完整无内皮细胞脱落现象,内膜下泡沫细胞及炎细胞浸润减少,内膜的NF-κB呈弱阳性表达,IκBα呈阳性表达,ICAM-1和MCP-1均呈阴性或弱阳性表达。

Results After the administration of morphine, there was a obvious increase of SOBP, SOCA and SOF; after the administration of anisodamine, there was a obvious decrease of SOBP and SOCA; after the administration of 10g of magnesium sulfate, there was a obvious decrease of SOCA.

结果 肌注吗啡后SO基础压、收缩幅度和胆总管压力均明显升高,SO收缩频率明显增快;肌注15mg山莨菪碱,SO基础压和收缩幅度明显下降;口服25%硫酸镁10g,SO收缩幅度明显下降。

The lungs of CDH fetuses were hypoplastic compared with normal controls and had thick walled septa with poorly developed saccules. In contrast, Dex and EGF fetuses showed improved mesenchymal differentiation with well-developed saccules and thin-walled septae, manifested by radial alveolar counts , mean terminal bronchiole density , ratio of pulmonary mesenchyma and that of pulmonary acinuses.

EGF组肺组织形态明显改善,表现在肺泡间隔变薄,肺泡面积所占比例明显增大,轴向腺泡计数较CDH组及Dex组均有明显增加,其平均终末支气管密度较CDH组改善明显,但仍少于正常对照组。

Histologically, the seminiferous tubules contained numerous Sertoli cells and more Sertoli-spermatozoa complexes, accompanied by the depletion of Leydig cells with deeply stained nuclei. Mature spermatozoa were stored up in the epididymis, but only a few in the efferent ducts. In the second place was testicular atrophy(32/120; 26.7%). The seminiferous tubules showed moderate to severe inactivity of spermiogenesis with evidence of only spermatogonia, spermatocytes and Sertoli cells. The Leydig cells were obviously decreased in numbers associated with decrease of lipid droplets in their cytoplasms. Testicular hypoplasia was the third disorders(22/120; 18.3%). Only a few spermatogonia and Sertoli cells appeared without any spermiogenesis. The associated changes was decreased in Leydig cells and fibrous hyperplasia in the interstitium.Epididymal stones were sometimes found(12/120; 10%). Grossly, yellowish-white nodules with various sizes and firm in consistency were observed in the epididymis and the front efferent ducts. Microscopically, the epididymal ducts were dilated with voluminous spermatozoa storage, even showed calcification in severe cases. The deposited calcium salts were stained positively by Von Kossa and Alizarin red methods.Amyloidosis was also detected in 10 roosters(8.3%). Eosinophilic, homogeneous, amyloid-like substances were deposited mainly in the testicular interstitium and the periphery of blood vessels. These substances showed positive reaction by Congo red staining. Five roosters(4.2%)had Marek's lesions in the testis, epididymis and peripheral nerves with infiltration of pleomorphic lymphocytes. Only one case showed epithelial necrosis of seminiferous tubules accompanied by fibrous proliferation in the interstitium.

结果发现,在总共搜集的120个病例中,其中因年老所导致的产精力不佳为最多,占38例(31.7%),於镜下可见大量精虫黏附於Sertoli cell的表面,并可见Sertoli cell数量明显增多而Leydig cell明显减少,且其细胞核呈现浓染的现象,而在其副睪中仍可见到成熟精虫蓄留於管腔中,但在其输精管内却只有少量精虫存在;其次为睪丸萎缩,占32例(26.7%),镜下可见中度至重度无造精作用,其生精小管中只见到精母细胞、精原细胞及Sertoli cell存在,但Leydig cell数量明显减少且其细胞质内的脂质也明显减少;睪丸发育不全,占22例(18.3%),於生精小管内只见到精母细胞及少量Sertoli cell存在,不见造精细胞分化,於生精小管间质可见Leydig cell减少并伴随结缔组织增生;副睪结石,占12例(10%),肉眼下可在副睪及输精管前段见到黄白色大小不一的结节,触感坚硬,於镜下可见副睪管扩张并有大量成熟精虫蓄积,严重时可见钙化现象,以Von Kossa及茜素红染色均呈阳性反应;类淀粉沉著症,占10例(8.3%),镜下在睪丸间质及血管周围可见粉红均质样的物质沉积,以刚果红染色成阳性反应;马立克病,占5例(4.2%),镜下可在睪丸、副睪实质及周边神经内均可见到嗜碱性大小不一的淋巴样细胞浸润;睪丸坏死,占1例(0.8%),镜下可见生精小管上皮细胞坏死脱落及间质结缔组织增生。

Results:Compared with the normal controls, manifestations of severe right heart failure,well-elevated pulmonary arterial pressure and serious right heart hypertrophywere observed in the pulmonary hypertensive rats 28 days after left lungresection and MCT injection.

结果:与对照组相比,MCT 注射后28 天大鼠出现重度右心衰竭征象,平均肺动脉压、右室肥厚度均明显升高;镜下可见明显肺血管重构,表现为右肺纤维化、肺小动脉内皮和中膜平滑肌层增生、血管密度降低;肺组织中HGF、eNOS 表达明显减少、TGF-β和ET-1 显著升高(P0.05),这些细胞因子表达量的改变与肺血管重构存在着明显的相关性。

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