时

This may eventually cause problems with patient access to these new therapies, the editorial suggests. All of the targeted therapies available to date are added onto conventional treatment, thus adding costs to the healthcare system."When the goal is to improve the chance for a cure, these new treatments seem to be well worth the expenditure," comments editorialist Hyman Muss, MD, from the Vermont Cancer Center, in Burlington."However, when the goal is to improve the quality of life or delay the time to progression by several months, as it is with many treatments for metastatic breast cancer, it is less clear whether the health system can and should bear these expenses."

当病患最终接触到这些新疗法时可能会发生问题，主编表示，目前为止，这些新的标靶疗法都是加在传统疗法之上，这对医疗系统造成负担；布灵顿Vermont 癌症中心Hyman Muss医师表示，当目标放在治癒时，这些新疗法是值得研究的，然而，当目标放在改善生活质量与减缓疾病进程时，仍有许多其它疗法可以选择，这些新药物应用在这种情形下的角色仍不清楚，且应该考虑医疗系统是否能够或是是否需要负担这些费用。

Its universality: its democratic equality and constancy to its nature in seeking its own level: its vastness in the ocean of Mercator's projection: its unplumbed profundity in the Sundam trench of the Pacific exceeding 8000 fathoms: the restlessness of its waves and surface particles visiting in turn all points of its seaboard: the independence of its units: the variability of states of sea: its hydrostatic quiescence in calm: its hydrokinetic turgidity in neap and spring tides: its subsidence after devastation: its sterility in the circumpolar icecaps, arctic and antarctic: its climatic and commercial significance: its preponderance of 3 to 1 over the dry land of the globe: its indisputable hegemony extending in square leagues over all the region below the subequatorial tropic of Capricorn: the multisecular stability of its primeval basin: its luteofulvous bed: its capacity to dissolve and hold in solution all soluble substances including millions of tons of the most precious metals: its slow erosions of peninsulas and islands, its persistent formation of homothetic islands, peninsulas and downwardtending promontories: its alluvial deposits: its weight and volume and density: its imperturbability in lagoons and highland tarns: its gradation of colours in the torrid and temperate and frigid zones: its vehicular ramifications in continental lakecontained streams and confluent oceanflowing rivers with their tributaries and transoceanic currents, gulfstream, north and south equatorial courses: its violence in seaquakes, waterspouts, Artesian wells, eruptions, torrents, eddies, freshets, spates, groundswells, watersheds, waterpartings, geysers, cataracts, whirlpools, maelstroms, inundations, deluges, cloudbursts: its vast circumterrestrial ahorizontal curve: its secrecy in springs and latent humidity, revealed by rhabdomantic or hygrometric instruments and exemplified by the well by the hole in the wall at Ashtown gate, saturation of air, distillation of dew: the simplicity of its composition, two constituent parts of hydrogen with one constituent part of oxygen: its healing virtues: its buoyancy in the waters of the Dead Sea: its persevering penetrativeness in runnels, gullies, inadequate dams, leaks on shipboard: its properties for cleansing, quenching thirst and fire, nourishing vegetation: its infallibility as paradigm and paragon: its metamorphoses as vapour, mist, cloud, rain, sleet, snow, hail: its strength in rigid hydrants: its variety of forms in loughs and bays and gulfs and bights and guts and lagoons and atolls and archipelagos and sounds and fjords and minches and tidal estuaries and arms of sea: its solidity in glaciers, icebergs, icefloes: its docility in working hydraulic millwheels, turbines, dynamos, electric power stations, bleachworks, tanneries, scutchmills: its utility in canals, rivers, if navigable, floating and graving docks: its potentiality derivable from harnessed tides or watercourses falling from level to level: its submarine fauna and flora, numerically, if not literally, the inhabitants of the globe: its ubiquity as constituting 90 percent of the human body: the noxiousness of its effluvia in lacustrine marshes, pestilential fens, faded flowerwater, stagnant pools in the waning moon.

50它的普遍性，它的民主的平等性，以及保持着它自身求平的本质。用墨卡托投影法在地图上所标示出的浩淼的海洋；太平洋中巽他海沟那超过八千噚的不可测的深度；永不消停、后浪推前浪地冲刷着海岸线每一部位的波涛以及水面上的微粒子；水的单位粒子的独立性；海洋变幻莫测；根据液体静力学，风平浪静时它纹丝不动；根据液体动力学，小潮大潮时它便涨了起来。暴风雨后一片沉寂；北极圈与南极圈冰冠地带的不毛性以及对气候及贸易的影响；跟地球上的陆地相比占三对一优势；它在亚赤道带南回归线以南的整个区域延伸无数平方海里的绝对权威；其在原始海盆里数千万年以来所保持的稳定性；它那橙红色海床；它那把包括数百万吨贵金属在内的可溶解物质加以溶解，并使之保持在溶解状态的性能；它对半岛和有下陷趋势的岬角所产生的缓慢的浸蚀作用；其冲积层；其重量、容积与浓度；它在咸水湖、高山湖里的静谧；其色调因热带、温带和寒带而变为或浓或淡；与陆上的湖泊、溪流及支流汇合后注入海洋的河川，还有横跨大洋的潮流所构成的运输网。沿着赤道下面的水路自北向南的湾流；海震、水龙卷、自流井、喷泉、湍流、漩涡、河水暴涨、倾盆大雨、海啸、流域、分水岭、间歇泉、大瀑布、漩流、海漩、洪水、泛滥、暴雨等滥施淫威；环绕陆地的上层土壤那漫长的曲线；源泉的奥秘可用探矿杖来占卜或用湿度测定器来揭示；阿什汤大门的墙壁上的洞、空气的饱和与露水的蒸发能够证明那潜在的湿度；水的成分单纯，是氢二、氧一的化合物；水的疗效；水的死海里的浮力；它在小溪、涧谷、水坝的缝隙、船舷的裂口所显示的顽强的浸透性；它那清除污垢、解渴、灭火、滋养植物的性能；作为模范和典型，它的可靠性；它变化多端：雾、霭、云、雨、麦、雪、雹；并在坚固的消防龙头上发挥出压力；而且千姿百态：湖泊、湖岔、内海、海湾、海岬、环礁湖、环状珊瑚岛、多岛海、海峡、峡江、明奇、潮汐港湾、港湾；冰河、冰山、浮动冰原显示出它是何等坚硬；在运转水车、水轮机、发电机、发电厂、漂白作坊、鞣皮厂、打麻厂时，它又是那样驯顺；它在运河、可航行的河川、浮船坞和干船坞所起的作用；潮汐的动力化或利用水路的落差使它得以发挥潜力；海底那些成群的动物和植物虽然并非名副其实地栖息在地球上，论数目却占地球上生物的一大半；水无所不在，占人体的百分之九十；在沼泽地、闹瘟疫的湿地、馊了的花露水以及月亏期那淤积污浊的水塘子，水所散发的恶臭充满了毒气。

The principal of buffer is described as follows.At impulsing down,the piston moves down and vacates the annular space.The pressure in respiratory cavity decreases to a certain level and the traveling valve opens.At that time,the liquids enter into traveling valve and cavity and the plunger is impulsed upward to carry out the gentle transient at the sudden change.When the upward impulsing begins,the respiratory cavity is subjected to pressure and the traveling valve closes.During the gradual pressure rising,the liquids in respiratory cavity effuse from the upper ventage and the sudden change of force-summing direction of plunger is relieved relying on the resistance of ventage.

其原理大致是：下冲程时，活塞向下运动，让出环形空间的体积，呼吸腔内压力下降，下降到一定水平后，游动阀打开，此时，游动阀和小孔同时进液，使柱塞在从上死点处突然改变方向向上运动时得到缓冲，实现了柔和过渡；当上冲程开始时，呼吸腔受压，游动阀关闭，在压力逐渐上升的过程中，呼吸腔内的液体从上部的小孔流出，并依靠小孔的阻力使柱塞受力突然换向得到缓冲。

It is found that the overall heat transfer coefficient of elliptic cylinder with k.0 is higher than that of a circular cylinder.At k=6.0,it has the maximum which is about 1.6 times that of a circular cylinder.At the same time,the drag coefficient drops down with the increase of k.For k=2.0,the drag coefficient is about 60％ that of a circular cylinder.

当k.0时，椭圆管的平均对流换热系数高于圆管；当k=6.0时，达到最大值，大约为圆管的1.6倍，同时，其阻力系数随着k的增大而减小；当k=2.0时，阻力系数约为圆管的60％。

Using algebraic methods which include extended Tanh-method,some new solitary solutions to the DBM and Log-DBM equation,such as singular solitary solutions,double singular peakon solitary wave solutions,double solitary wave solution with peakon and singular periodic solitary wave solutions are obtained..With the aid of an auxilitary function combined with the elliptic integral of the first kind,periodic solitary solution,singular and periodic singular solitary solutions can be obtained.

第三章利用扩展的Jacobi椭圆函数展开法研究了方程，并给出ZK-MEW方程的Jacobi椭圆函数解，特别的，当模数m→0和m→1时，其中一部分解退化为三角函数解和孤立波解；其次使用sn-cn拟设法，研究了K(k，s，1)方程，得到了k=s=3时的新的精确解，并在模数m→0和m→1时得到了丰富的三角函数和孤立波解。

Methods Through the triaxial creep test, the triaxial creep curves and isochorounous stress-strain curves have been obtained, then the creep characteristics of mica-quartzose schist have been obtained by analyzing the triaxial creep curves, and the isochrounous stress-strain characteristics of mica-quartzose schist have been obtained by analyzing the isochorounous stress-strain curves. Finally, an empirical formula of creep curve is obtained by data fitting and the analysis of the relation between time and parameter of fitting formula.

通过三轴蠕变试验首先得到了云母石英片岩的蠕变曲线和应力应变等时曲线，然后对试验曲线进行分析得到云母石英片岩的蠕变特性和云母石英片岩的等时应力应变特性，最后拟合应力应变等时曲线，并分析时间和拟合公式中参数的关系，得出了蠕变经验公式。

The influences of the shock thickness and Alfven waves on the particle acceleration by diffusive shock waves are numerically studied through solving one-dimensional diffusive equation including the second-order Fermi effect. It is shown that the spectral index of the energetic particles strongly depends on the shock thickness. For example, the spectral index increases from 2.1 to 3.7 in the low energy range of 3-10 MeV and from 2.5 to 5.0 in the high energy range of 20-60 MeV as the thickness increases. The spectral index decreases from 4.3 to 3.1 as the particle injection energy increases. The spectral index decreases from 4.0 to 1.8 at the quasi-steady stage with the enhancement of the compression ratio from 2 to 4. The results indicate that under the influence of Alfven waves, the energetic particle spectrum at lower energy becomes flat and the spectral index decreases from 2.5 to 0.6 in the low energy range of 3-10 MeV and from 11.6 to 5.0 in the high energy range of 20-60 MeV. At the same time, the rollover energy reaches 19.6 MeV. The spectral index decreases from 5.8 to 2.9 as the energy density of Alfven waves increase. All these results are basically consistent with the theoretical models, as well as the observations of typical energetic particle events.

通过数值求解包含二阶费米加速的一维扩散方程，探讨在准平行激波条件下激波厚度和级联阿尔芬波对粒子加速的影响，研究粒子分布函数的演化与激波厚度和阿尔芬波强度的内禀关系，计算结果表明：(1)考虑激波厚度时，谱指数明显依赖于激波厚度，随着厚度从0.32增大到2.56，低能端(3-10MeV)谱指数逐渐从2.1增加到3.7，高能端(20-60MeV)谱指数从2.4增大到5.0，能谱逐渐变软；当初始注入粒子动量增大1.3倍，质子能谱指数从4.3减小到3.1，且与零厚度激波加速的谱指数差值缩小；厚度不变时，随着压缩比从2增加到4，准稳态分布时低能端(3-10MeV)粒子能谱指数逐渐从4.0减小到1.8谱变硬；(2)在级联阿尔芬波的影响下，随着时间的增大，粒子在低能处(3-10MeV)的谱指数从2.5减小到0.6高能端(20-60MeV)谱指数从11.6减小到5.0，能谱变硬，拐点能量值从7.5MeV增大到为19.6MeV；随着波的能量密度增大，谱指数从5.8减小到2.9，这表明阿尔芬波强度越大，加速效率越高，通过与激波厚度解析结果和高能粒子事件的观测能谱比较发现两者是一致的，说明数值模拟结果是可靠的。

The SiC slurry catched high thixotropy when the SiC powders were coated all by hydrophile groups, and the viscosity of the SiC slurry would increase 1236.0mPas suddenly when its solid loading added from 57.4% to 58.5%; If the SiC powders were coated by lipophile group, the thixotropy of the SiC slurry would reduce and the enhancive scope of the high solid loading SiC slurry's viscosity would also be weakened.

改性粉表面全是亲水基团时，料浆触变性大，当固相体积含量由57.4%上升到58.5%时，料浆粘度突然增大1236.0mPaS；随着亲油基团的引入，料浆触变性降低，高固相含量时粘度增大平缓。

Under ADAMS environment,it establishes 6-DOF powertrain test rig model and studies the characteristic of force entent and frequency on the condition of sympathetic vibration by means of the performance of ER fluid, it is known that the value of force is small when electric field is strengthened at low rotation speed and the value of force is small when electric field is weakeded at high rotation speed.

利用电流变隔振器的性能，在ADAMS下建立发动机6自由度的仿真模型，通过频域分析，我们可以发现，当发动机在低速运转时，加大电场会使得发动机在共振频率时的幅值较小，而当发动机在高运转时，情况恰恰相反。

In blastula embryos and 50% epiboly embryos, the zygotic pou2 transcript is also distributed in every blastomere cell. At the stage of 90% epiboly, expression of pou2 converges to the dorsal midline of embryos and locates in two waves of lateral neural plate and two transverse stripes in the brain region. In embryos at 100% epiboly, pou2 transcript is restricted in the neural plate and areas of presumptive midbrain amid himdbrain. From somite stage, gibel carp pou2 can not be detected any more, which is consistent with the RT-PCR result.

在高囊胚期和50%下包期，高度表达的合子转录本仍在所有的胚盘细胞中，但至90%下包期时，pou2的表达向胚胎背部的正中线汇聚，集中在神经板的两侧区域和脑部的两条横向条带在100%下包期时，pou2的表达集中在神经板的中间区域以及预期形成的中后脑区域至体节期时，转录本消失，这与RT-PCR结果高度一致。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。