早幼粒细胞

Objective To study the mechanism of drug resistance of APL to ATRA and the methods of reversion.

目的 揭示急性早幼粒细胞白血病产生维甲酸耐药的机制，探讨耐药性逆转的方法。

RESULTS : Twenty－five patients were treated with arsenous acid. Among them, 2 4 reached CR (CR rate 96%), 1 no remission.

结果：亚砷酸治疗25例复发急性早幼粒细胞白血病，24例达完全缓解，1例未缓解，缓解率96%。

Arsenous acid solution is an effective drug for the treatment of relaps ed APL which was resi stant to tretinoin.

亚砷酸是治疗对维A酸耐药的复发急性早幼粒细胞白血病的有效药物，并相对比较安全。

AIM: To evaluate the effectiveness of arsenous aci d (As2O3) injectable solution in the treatment of relapsed acute promyelocyti c leukemia.

目的：观察亚砷酸对复发的急性早幼粒细胞白血病的疗效。

ABSTRACT AIM: To evaluate the effectiveness of arsenous aci d (As2O3) injectable solution in the treatment of relapsed acute promyelocyti c leukemia.

目的：观察亚砷酸对复发的急性早幼粒细胞白血病的疗效。

METHODS : Twenty－five relapsed APL patients were enrolled (M 15, F 10, 3 4 a±s 12 a), 10 mL of 0.1% arsenous acid solution+5% glucos e 500 mL was injected iv, dr ip, daily for 28－56 d.

复发的急性早幼粒细胞白血病25例(男性15例，女性10例；年龄34a±s 12 a)以亚砷酸10mg/d+5%葡萄糖注射液500 mL静脉滴注，28～56 d为一个疗程。

Subacut myeloid leukemia can be a defined type of leukemia. The common characteristics of subacute myeloid leukemia are as follows: the onset is insidious, and anemia and hemorrhage of skin and mucosa are the main clinical manifestations. Hepatosplenomegaly is rare. There are multilineage abnormalities in blood cell counts and increased blasts in the bone marrow with cytogenetical abnormal clone in most cases. The disease course is subacute and progressive.

1、亚急性髓性白血病是一个可以确定的白血病类型，其特征为：起病隐袭，以贫血或皮肤粘膜出血为主要症状，肝脾肿大的特征较少，血象为一系、二系或三系的异常，骨髓细胞形态学检查原早幼粒细胞异常增高，细胞遗传学检查多数有克隆性异常核型，病程中可有克隆演进，呈现亚急性而进行性的临床经过。

Acute promyelocytic leukemia and acute monocytic leukemia are subtypes of AML that need different treatment than other subtypes of AML.

急性早幼粒细胞性白血病和急性单核细胞白血病是急性髓细胞性白血病的两个亚型，对这两个亚型的治疗不同于其他亚型。

Acute promyelocytic leukemia and acute monocytic leukemia are subtypes of AML that need different treatment than other subtypes of AML.

急性早幼粒细胞白血病和急性单核细胞白血病是急性髓细胞白血病的两个亚型，其治疗方法不同于其他亚型。

Acute promyelocytic leukemia and acute monocytic leukemia are subtypes of AML that need different treatment than other subtypes of AML.

急性早幼粒细胞白血病和急性单核细胞白血病是急性髓细胞白血病的其中两个亚型，治疗方法不同于其他亚型。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。