早幼粒细胞

Objective:To explove the mechanism of BCB treating leukemia and investigate the apoptosis of leukemic cells induced by BCB.and its action on cell cycle.

为探讨乳香抗白血病的作用机制，研究乳香诱导急性早幼粒细胞白血病细胞凋亡与细胞周期关系。

Objective To study the effect of all-trans retinoic acid and arsenic trioxide (As2O3) on tissue factor expression and procoagulant activity of acute promyelocytic leukemia cells in vivo and in vitro.

目的探讨全反式维甲酸和三氧化二砷（As2O3）在体内外对急性早幼粒细胞性白血病细胞组织因子表达的影响。

The significance of combined therapy of arsenic trioxide and alltrans retinoic acid in treating acute promyelocytic leukemia.

全反式维甲酸联合三氧化二砷治疗初发急性早幼粒细胞白血病的疗效观察。

Objective To investigate the effects of all-trans retinoic acid,arsenic trioxide(As2O3) and daunorubicin on tissue factor expression in acute promyelocytic leukemia cell line NB4 cells.

目的 探讨全反式维甲酸、三氧化二砷（As2O3）及柔红霉素对急性早幼粒细胞白血病细胞株NB4细胞组织因子表达的影响。

Over the past year, the group evaluated the seven-year follow-up results of therapeutic effects of all-trans retinoic acid and arsenic trioxide (As2O3) combined treatment in newly diagnosed acute promyelocytic leukemia. We also studied the mechanism of therapeutic effects of Imatinib and As4S4 combined treatment in CML cell line and animal model. These two papers were published on PNAS.

过去的一年中，本课题组总结完成了全反式维甲酸和三氧化二砷联合治疗初发急性早幼粒细胞白血病的七年临床随访资料的疗效评估；在慢性粒细胞性白血病，完成了应用As4S4和STI571联合治疗作用的细胞、分子和整体动物水平的机制研究，这两部分工作均已发表于PNAS。

For example, Vitamin B12 and folic acid apply to megaloblastic anemia; chalybeate only apply to iron-deficiency anemia, and cannot be used with other types, since this will cause an overdose of iron, which will influence the function of some important organs (such as the heart, liver and pancreas);vitamin B6 applies to sideroblastic anemia; corticosteroid applies to autoimmune hemolytic anemia; testosterone applies to aplastic anemia, etc.

例如维生素B12及叶酸适用于治疗巨幼细胞性贫血；铁剂仅用于缺铁性贫血，不能用于非缺铁性贫血，因为会引起铁负荷过重，影响重要器官的功能；维生素B6用于早幼粒细胞性贫血；皮质类固醇用于治疗自身免疫溶血性贫血；睾丸酮用于再生障碍性贫血等。

Chalybeate only apply to iron-deficiency anemia, and cannot be used with other types, since this will cause an overdose of iron, which will influence the function of some important organs (such as the heart, liver and pancreas).vitamin B6 applies to sideroblastic anemia. corticosteroid applies to autoimmune hemolytic anemia. testosterone applies to aplastic anemia, etc.

例如维生素B12及叶酸适用于治疗巨幼细胞性贫血；铁剂仅用于缺铁性贫血，不能用于非缺铁性贫血，因为会引起铁负荷过重，影响重要器官的功能；维生素B6用于早幼粒细胞性贫血；皮质类固醇用于治疗自身免疫溶血性贫血；睾丸酮用于再生障碍性贫血等。

No primitive blood cells were observed in liver, which implies that the liver was not the hemopoietic organ in C. mydas. The development of erythrocytes includes 5 stages: primitive, early, middle, late, and mature. The body sizes of these cells increased first, then decreased, and increased in the end. The development of granulocytes includes 5 stages also: myeloblast, promyelocyte, meddle immature granulocytes, late immature granulocytes, and mature granulocytes. The body sizes of them decreased; and the sublobe of the nuclear may indicate the aging.

红血细胞的发育经历了5个阶段：原红血细胞、早幼红血细胞、中幼红细胞、晚幼红血细胞和红血细胞等阶段，其胞体体积经历了由小到大，由大到小、再到大的发育过程；粒细胞的发育经历了5个阶段：原粒细胞、早幼粒细胞、中幼白细胞、晚幼白血细胞和白细胞等阶段，胞体体积均由大到小变化，核分叶可能是粒细胞的衰老的标志；淋巴细胞和单核细胞的发育各经历了3个阶段。

The percentage of myeloblasts and promyelocytes of the patients with myelodysplastic syndrome increased when compared with that of controls.Morphological changes including nuclear abnormalities were also observed in granulocytic and erythrocytic lines.

骨髓增生异常综合征患者骨髓中原粒和早幼粒细胞百分率高于正常，分别为5.08和7.85(正常参考值分别为0.64和1.59)，粒细胞和红细胞有细胞形态异常和核畸形。

Among the cases, hypergranular promyelocytic was present in 15%. Infected bone marrow and megaloblastic anemia were observed in 5% respectively. Fungi infected bone marrow and idiopathic thrombocytopenic purpura were found in 2.5% respectively. Pure red cell aplasia and granulocytic series deficiency due to regenerative granulocyte failure were observed in 2.5% respectively.

在40例艾滋病患者中，反应性早幼粒细胞增多者占15％，感染性骨髓象和巨幼细胞性贫血各占5％，真菌感染性骨髓象和特发性血小板减少性紫癜各占2.5％，纯红再障和生成减少性粒细胞缺乏症各占2.5％。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。