早

Objective To study the effect of all-trans retinoic acid and arsenic trioxide (As2O3) on tissue factor expression and procoagulant activity of acute promyelocytic leukemia cells in vivo and in vitro.

目的探讨全反式维甲酸和三氧化二砷（As2O3）在体内外对急性早幼粒细胞性白血病细胞组织因子表达的影响。

The significance of combined therapy of arsenic trioxide and alltrans retinoic acid in treating acute promyelocytic leukemia.

全反式维甲酸联合三氧化二砷治疗初发急性早幼粒细胞白血病的疗效观察。

Objective To investigate the effects of all-trans retinoic acid,arsenic trioxide(As2O3) and daunorubicin on tissue factor expression in acute promyelocytic leukemia cell line NB4 cells.

目的 探讨全反式维甲酸、三氧化二砷（As2O3）及柔红霉素对急性早幼粒细胞白血病细胞株NB4细胞组织因子表达的影响。

Objective:To observe the therapeutic efficacy and side effect of all-trans retinoic acid combined with arsenic trioxide(As2O3)on newly-diagnosed patients with acute promyelocytic leukemia.

目的：观察全反式维甲酸联合三氧化二砷(As2O3)治疗初发急性早幼粒细胞白血病的疗效和不良反应。

AbstractObjectiveTo observe the therapeutic efficacy of all-trans retinoic acid combined with arsenic trioxide(As2O3) on acute promyelocytic leukemia.

中文摘要：摘要目的研究全反式维A酸联合三氧化二砷治疗急性早幼粒细胞性白血病可产生的协同作用。

Acute promyelocytic leukemia ; All-transrefinoic acid ; Arsenic

急性早幼粒细胞白血病；全反式维甲酸；砷剂

ABSTRACT］ Objective To observe the efficacy and side effects of combined therapy with alltrans retinoic acid, arsenic trioxide (As2O3) and chemotherapeutics for newly diagnosed acute promyelocytic leukemia.

急性早幼粒细胞白血病是急性髓系白血病中的一种独特类型(M3型)，以特异的染色体易位t(15，17)(q22，q21)为特征，形成PMLRARa融合基因，该融合基因是APL发病的分子基础和分子标志。

Over the past year, the group evaluated the seven-year follow-up results of therapeutic effects of all-trans retinoic acid and arsenic trioxide (As2O3) combined treatment in newly diagnosed acute promyelocytic leukemia. We also studied the mechanism of therapeutic effects of Imatinib and As4S4 combined treatment in CML cell line and animal model. These two papers were published on PNAS.

过去的一年中，本课题组总结完成了全反式维甲酸和三氧化二砷联合治疗初发急性早幼粒细胞白血病的七年临床随访资料的疗效评估；在慢性粒细胞性白血病，完成了应用As4S4和STI571联合治疗作用的细胞、分子和整体动物水平的机制研究，这两部分工作均已发表于PNAS。

The company is engaged in domestic earlier Wooden and paper art packaging companies.

公司是国内较早从事木艺和纸艺包装的公司之一。

Methods Sequence specific primers-polymerase chain reaction was used for the detection of genotypes and alleles of rs3850641 A/G loci in OX40L gene in 187 PACS cases (≤55 years) and 138 controls. Diseased vessel numbers and stenostic severity integral by coronary arteriogram and serum levels of sOX40L, C-reactive protein and vascular cell adhesion molecule-1 (VCAM-1) by enzyme-linked immunosorbent assay and nephelometry were measured. The relationship between OX4OL gene variants and PACS risk, SSI as well as plasma levels of three cytokines were analysed.

采用聚合酶链反应－序列特异性扩增技术检测187例年龄≤55岁、早发急性冠状动脉综合征患者和138例冠状动脉造影正常者rs3850641位点A/G变异的基因型、等位基因及其分布频率；采用冠状动脉造影测量病变血管支数和狭窄程度积分；应用ELISA法测试血浆sOX40L、血管细胞黏附分子(VCAM-1)；应用散射比浊法测试血浆C反应蛋白水平；分析OX40L基因变异与ACS风险、冠状动脉病变程度和血浆3个细胞因子之间的关系。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。