无髓的

We identified a novel NMO lesion in the spinal cord and medullary tegmentum extending into the area postrema, characterized by AQP4 loss in foci that were inflammatory and oedematous, but neither demyelinated nor necrotic.

我们在对脊髓和延髓背盖延伸入最后区的一个异常NMO病灶研究中证实，该病变仅表现为以AQP4缺失为特征的炎性水肿，既无脱髓鞘也无坏死。

Recently, many foreign researchers found that the tetrodotoxin-resistant voltage-gated sodium channel, Nav1.8, which is expressed only by unmyelinated small-diameter sensory neurons associated with nociception in dorsal root ganglion and trigeminal ganglion, is involved in pain pathways and play a key role. Thus it provides a new idea in pain research.

近年来，国外众多学者发现河豚毒素(tetrodotoxin，TTX)不敏感型(TTX-resistant，TTX-R)电压门控钠通道Na_v1.8与疼痛的关系极为密切，其仅分布在背根神经节(dorsal root ganglion，DRG)和三叉神经节(trigeminal ganglion，TG)中的与伤害性感受密切相关的无髓鞘的小直径感觉神经元胞体上，它为疼痛的研究提供了新的思路。

We introduced improved primary mixed glial culture and different-attachment method to isolate and purify the OPCs, the cells were proliferated in serum-free medium, flow cytometry and immunohischemistry methods were employed to estimate the purity of cultured OPCs. Their abilities of differentiation and expression of trophic factors were identified by RT-PCR and immunostaining. Several methods including TUNEL and MTT were adopted to estimate the protective effects of conditioned culture medium from oligodendrocyte lineage cells on the primary cultured cerebellar granule neurons. Intravitreal transplant of OPCs, combined with retrograde fluorescent labeling the superior colliculus and intraorbital optic nerve transection, were used to investigate the protective effects of OPCs on the axotomized RGCs in vivo. Intravitreal transplantof OPCs or NSCs on the newborn rats, and retinal transplant of OPCs on the young rats were performed, to observe the myelin formation in the retina at different stages after cellular transplantation. Optic nerve transection was carried out on some rats with myelinated retinae, to study the influence of myelination on the injuried RGCs.

为此，本研究采用改良的胶质细胞混合培养与差速贴壁方法获得大鼠OPCs，使用无血清培养基进行扩增、培养，用免疫组织化学和流式细胞技术对培养细胞的纯度进行鉴定，对少突胶质系细胞表达部分营养因子的情况进行检测；采用TUNEL、MTT等方法对少突胶质系细胞条件培养基对原代培养小脑颗粒神经元的保护作用进行检测；将OPCs移植入成年SD大鼠玻璃体内，利用上丘逆行荧光标记技术，观察眼内移植的OPCs对眶内视神经切断时的视网膜神经节细胞的保护作用及其持续时间；将OPCs或NSCs移植入新生和幼年SD大鼠玻璃体或视网膜内，观察不同时期视网膜内髓鞘形成与分布特点，分析髓鞘的超微结构，并观察眼内髓鞘形成对损伤神经节细胞的保护作用。

Of the 26 lesions with pontine and bulbar involvement, three had no association with other lesions (Fig 2). Twelve were associated with tegmental and superior cerebellar peduncular extension, and six showed corticospinal tract involvement in continuity with an MDJ lesion. In one patient with additional telencephalic lesions, the right side of the pons was hyperintense on long TR/TE images that did not cross the midline, suggestive of an arterial lesion (Fig 3). In two patients with pontine tegmental lesions, there was an associated middle cerebellar peduncle and deep cerebellar white matter involvement (Fig 4). Two others had associated cervical lesions.

在26处脑桥延髓区病灶中，3处病灶仅限于脑桥延髓区，其它部位无病灶（图2）；12处病灶还同时伴有背盖部和小脑上脚/结合臂处病灶；6处病灶为与中脑-间脑接合处病灶相连的皮质脊髓束受累；还有1例患者除端脑见病灶外，右侧脑桥于T2像也见高信号病灶，但未超越正中线，提示可能系动脉病变所致（图3）；2例脑桥背盖部病灶的患者同时伴有小脑中脚/小脑脑桥脚和小脑深部白质受累（图4）；还有2处脑桥延髓区病灶还同时伴有颈髓病灶。

The follow-up periods were various from 6m to 21m. The apical MTA barrier technique was used to manage pulpless permanent teeth with incomplete root formation. The postoperative radiographs showed complete repair of periradicular tissue in 5 of 7 teeth and improvement obviously in other 2 teeth. Only one case (1 tooth) had a 3mm periodontal pocket in four perforation repair cases. The lesion at the perforation sites was improved obviously.

追踪观察时间为6-21月。4例穿孔修补的病例，均为延迟修补，除一例为根尖1／3处的病理性吸收外，其余患牙的穿孔部位位于牙根的冠1／3或根分叉处，一例6m复查时有3mm的牙周袋形成，其余患牙骨吸收暗影均明显缩小。7例根尖发育不全并无髓牙的病例均为成人，5例根尖暗影完全消失，2例明显缩小。

Maxillary central incisors had a slightly greater pulpal blood flow values than maxillary lateral incisors. The flow values from 15 teeth with necrotic pulp or pulpless teeth were significantly lower than that from the control teeth. Before therapy the values from 16 deep caries teeth were all higher than that from the control teeth. After therapy, most (15/16) of those values decreased to normal in three days. The value of one tooth with deep caries remained high, and one week later, the pulp became necrosis.

由死髓牙测得的流量值显著小于正常对照。16颗深龋患牙治疗前牙髓血流量皆高于正常对照组，治疗后有15颗患牙的血流量很快降至正常，有1颗患牙在治疗后血流量无明显变化，最终发生牙髓坏死。

Methods: We established an experimental model of rat molars pulpitis, used homemade Calcium hydroxide compound as pulp-cap in pulpotomy of rats' teeth, Calvital and blank were det as the control groups. Forty rats' teeth in each group were observed using light microscope 4 and 12 weeks after pulpotomy.

建立大鼠早期牙髓炎的模型，应用自制氢氧化钙复合制剂作为鼠牙牙髓切断术的盖髓剂，以calvital作对照组及无盖髓剂作为空白对照组。

Result: Schwann-like cells disperse in the hole of nerve graft at oneweek under Scanning Electronic Microscope, the processes of thesatellite-like cells adhere to the wall of graft.There was no statisticaldifference of activity of cells in both group(P＞0.05) using MTT. At 12weeks,the result of appearance, histology and TEM were similar, therewere no statistical difference in SFI%, NEP and quantitative analysis ofrecovery rate of myelinated fiber populations, diameter of myelinatedfiber and thickness of myelin sheat.

结果：1w后扫描电镜下可见接种的类Schwann细胞分散在材料表面的孔隙内，细胞形态为星状，细胞突起与支架管壁粘附；MTT法测定细胞活性示神经支架组在各时间点与对照组无显著性差异P＞0.05；12w时两组动物坐骨神经外观、组织学光镜观察、透射电镜观察结果相似、两组坐骨神经功能指数恢复率、神经电生理、再生有髓神经纤维计数恢复率、神经纤维直径恢复率、髓鞘厚度恢复率等指标相比无显著性差异(P＞0.05)。

67 of old person latent to split tooth carry on clinical diagnosis, adopt the complex treatment method according to different situations to 63. 4 shallow form latent to split tooth, dental pulp normal having subjective symptoms to be only competent to transfer tooth treat jointly; Have deeper crackle as to 5, the vigor of dental pulp is normal, but there is trouble tooth of dentine irritated symptom, prepares against the hole, is filled with on the crack while adjusting the tooth contract; Pulpitis, 22 58 drops of trouble tooth with the sharp disease, symptom of the root already appear to 36, go ahead of the rest steel wire ring pitch or make, bring ring bonding in order to protect corona, rub except that high sharp abrupt slope, after dispelling the tooth and shutting the wound, the root canal with complete regeneration, observe for 2 weeks, after there is no clinical symptom, preceded and repair completely in time.

对63例老年人67颗隐裂牙进行临床诊断，并根据不同情况采用了综合治疗的方法。4颗浅表的隐裂牙，牙髓正常且无自觉症状仅行调牙合治疗；对于5颗有较深裂纹，牙髓活力正常，但有牙本质过敏症状的患牙，调牙合同时在裂隙处备洞、充填；对36颗已出现牙髓炎、22颗伴有根尖病症状的58颗患牙，先行钢丝环扎或做带环粘结以保护牙冠，磨除高尖陡坡，消除牙合创伤后，再行完善的根管治疗，观察2周，无临床症状后，及时做全冠修复。

This study is aimed to address the question whether the early discharges can affect thesilent period and modulate the late discharges and to investigate the possiblerole of dysfunction of primary myelinated afferents in generation of chronicpain. In addition, we also investigate the effect of the precedingA-conditioning stimuli with graded numbers on the late discharges of WDRneurons evoked by a following nociceptive test stimulus that activates bothA- and C-fibers.

在定义WDR神经元的反应特性时，通常用一个短促的电刺激刺激相关的神经干，激活A及C类纤维，这时可记录到一个反映有髓纤维传入的高频短促的早成分放电，接着是一个无放电的宁静期，最后是C纤维激活所诱发的晚成分放电，这种放电形式有别于脊髓背角的其它神经元。

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了