无角化

Results: The PCNA mean labelling index was 48.84％± 13.63％, and the apoptotic labelling index was12.26‰± 5.20‰. The Kaplan-Meier survival curves showed that the postoperative survival time of the patient was shorter when the tumor infiltrated to the adventitia of esophagus,with lymph node metastasis, without keratinization, PI ≥ 40％ or AI＜10‰. Using forward multivariate Cox regression analysis, only the parameters of pN category and PI could be verified as independent prognostic factors.

结果：36例手术切除的食管鳞癌组织平均PCNA表达指数(PCNAlabellingindex，PI)为48.84％±13.63％，细胞凋亡指数(apoptosisindex，AI)为12.26‰±5.20‰；PI升高与患者年龄小、分化程度低、有淋巴结转移和肿瘤进行性浸润呈正相关，而AI升高与分化程度高、角化明显呈正相关；绘制Kaplan－Meier生存曲线，发现病变侵及食管外膜、有淋巴结转移、无角化、PI≥40％或AI＜10‰的患者术后生存率明显降低；COX比例风险模型分析，发现只有淋巴结转移和PI是影响预后的独立因素。

Neither nail change nor mucosal involvement was noted. The biopsy specimen taken from the thigh showed characteristic acantholysis and dyskeratosis. The clinical and histological differential diagnoses are presented and discussed.

患者无家族史，亦无指甲与粘膜病变，大腿皮肤病灶切片，病理显示典型棘层分解与角化不全，关於临床及病理下类似的鉴别诊断，将在本文中加以讨论。

Results In normal tongue mucosa and LP,the positive staining of Notch1 was mainly distributed in stratum corneum, partially in stratum granulosum and stratum spinosum, but not in stratum basale, while the positive staining of EGFR was mainly distributed in stratum basale, rarely in stratum spinosum, but not in stratum granulosum and stratum corneum.

结果 在正常舌黏膜和LP中，Notch1阳性表达主要位于角化层，部分颗粒层和棘层细胞也有表达，基底层无表达；而EGFR阳性表达主要位于基底层，棘层少见表达，颗粒层和角化层无表达。

At each age stage , Skin appears over - cornified cuticle , disappeared hair shaft and abnormal hair bulb and hair follide that filled with some cornified substances , but the dermis varied.

各年龄段无毛小鼠表皮均有一层角化过度的角质层，毛干消失，毛球结构不正常，毛囊被一些角化物质充填。

2The involvement of MFT in woman is more than that in man.(3)The patients showed multiple dome-shaped, skin-colored, firm papules on the face. Some patients also present the lesions on the scalp and neck. No lesion showed the malignant tendency.(4) The histologic findings of MFT are cornified cysts and some nests of basaloid epithelial cells.(5)There were variable clinical expressions in different patients of the same family.(6) Some pedigrees were also affected by feckle or symmetrical progressive erythrokeratoderma, which were not found in MFT patients of other origin.

MFT临床分析总结：①MFT遗传方式为常染色体显性遗传；②女性发病多于男性；③中国汉族人MFT的典型皮损特征为面部乳白色半球形或圆锥形丘疹，质地坚实，只有2个家系皮损分别发生于头皮及颈部，均无恶化倾向；④组织病理特征为角质囊肿和由基底样瘤细胞构成的肿瘤岛；④同一家系中不同的患者表现度不同；⑤个别家系可伴发雀斑及进行性对称性红斑角化症，其它家系不伴发其他疾病。

While porokeratosis is practically asymptomatic,unusual pruritic variant has been reported and designated as "eruptive pruritic papular porokeratosis" or "inflammatory stage of DSP".

本病一般无临床症状，但伴明显瘙痒的汗孔角化症已经有文献报告，并被命名为&发疹性瘙痒性丘疹型汗管角化症&或&处于炎症反应期的DSP&。

Short and stubby hands and absent thumbs, eye abnormalities including iris dysgenesis, porokeratosis and cataracts, annular pancreas, duodenal stenosis.

粗短手并无拇指，眼部异常：包括虹膜发育不良、汗孔角化症和白内障，环状胰腺，十二指肠狭窄；32个病人因白内障被筛过。

KCOT epithelial cells could be serially cultured in vitro in K-SFM by techniques suggested in this study.

采用无血清的角化细胞培养基可在体外进行牙源性角化囊性瘤上皮细胞的连续培养。

When she was one year old,there was obvious inflammatory at the edge of cutinized layer ,which begun to expand to dorsal aspects of hands and feet.She had no family history.

十二个月大学步，炎症明显，角化层目前有向手、脚背扩展趋势，用过多种外敷药，效果不明显，我们夫妇及上两代都无此症状。

Mean ApoL I of keratinizing types(15.77±4.34) was significantly higher than those of nonkeratinizing types (8.03±1.70). The ApoL I increased from 6.51±0.58 with poorly differentiated cancers through 10.58±2.90 with moderately differentiated cancers to 18.41±4.49 with well differentiated cancers. There was no apparent correlation between ApoL I and sex, age, tumor size, tumor location and tumor infiltrative depth. The Kaplan-Meier survival curves between ApoL I＜10‰ and ApoL I≥10‰ have significant difference, while the former has a shorter survival time.

角化型ApoL I高于非角化型(P＜0.01)；肿瘤分化越好，细胞凋亡越多，低度、中度、高度分化ApoL I有差异(P＜0.05)；不同性别、年龄、肿瘤部位、长度、深度，其ApoL I并无差异；以10‰为界将ApoL I分组绘制Kaplan-Meier生存曲线，ApoL I≥10‰组术后生存率高。

I didn't watch TV last night, because it .

昨晚我没有看电视，因为电视机坏了。

Since this year, in a lot of villages of Beijing, TV of elevator liquid crystal was removed.

今年以来，在北京的很多小区里，电梯液晶电视被撤了下来。