无脑

Sample selection criteria for inclusion in our study were as follows: admission to our study, the course was less than 3 weeks, no history of prior stroke. Accelerate hypertension, severe disease of lever, kidney heart, malignant tumor, the history amentia or psychosis, respiratory failure were excluded. 80 patients were randomized divide d two groups :one control group and one rehabilitation group. Interventions Traditional neurology therapies were given to all patients.

患者 连续入院年龄在40～80岁男性或女性脑梗死或出血患者，病程不超过3个星期，既往没有脑卒中病史，无活动性肝病，肝功能不全，无充血性心力衰竭，无恶性进行性高血压，无恶性肿瘤患者，既往无痴呆病史，聋、哑人不能入组，且患者愿签署知情同意书，生命体征稳定在一周内，有肢体功能障碍。80例病人被随机分配到康复组和对照组。

Although does not have the obvious clinical manifestation,but it is the symptom cerebral infarction\'s one kind of omen,therefore has the necessity very much to this sickness\'s research.3、The discussion diabetes mellitus merge cerebral infarction\'s CT characteristic,CT blocks the stove spot and the cerebral infarction whether to have the symptom to relate.4、Diabetes merge symptomless cerebral infarction not easily notes by the patient and doctor or neglects,continues to have the cerebral infarction again easily,no matter but is symptomless perhaps has the symptom, can cause patient\'s cognition function to receive the harm.

虽没有明显的临床表现，但它是症状性脑梗塞的一种前兆，因此对此病的研究很有必要。3、探讨糖尿病合并脑梗塞的CT特点，CT梗塞灶部位与脑梗塞是否出现症状的相关系。4、糖尿病合并无症状性脑梗塞不易被患者及医师注意到或忽略，易再继续发生脑梗塞，而不管是无症状性或是有症状性的，都能使患者的认知功能受到损害。

Therefore the prevention further aggravates.5、The discussion prevents and controls or not and diabetes merge symptom cerebral infarction\'s transformation hazard factor relations to diabetes merge symptomless cerebral infarction.6、The discussion diabetes merge symptom and the symptomless cerebral infarction\'s Chinese medicine dialectical characteristic,is advantageous to knew the symptom and the card formation mechanism,manifest the Chinese medicine concept of viewing the entire situation,the display Chinese medicine treatment superiority.

因而预防进一步加重。5、探讨对糖尿病合并无症状脑梗塞防治与否和糖尿病合并症状性脑梗塞的转化的危险因素关系。6、探讨糖尿病合并症状性与无症状性脑梗塞的中医辨证特点，有利于重新认识症状与证型的形成机理，体现中医整体观念，发挥中医药治疗优势。

24H treatment group compared with 24h model group: the level of MCP-1 of the Gardenoside group decreased, but the level of MIP-1 of it is no different with the model group; the level of the MCP-1 of the Baicalin group increase and the level of MIP-1 of it all decreased; the level of MCP-1 and MIP-1 of the Concha Margatitifera Usta all decreased; the level of MCP-1 of the Cholic Acid group decreased and the level of MIP-1 is no different with the model group; the level of MCP-1 and MIP-lof the Hefang Group decreased than the model group.

在本实验中，脑缺血能够诱导P53蛋白表达，P53蛋白可能参与调控缺血后神经细胞延迟性死亡的病理生理过程，药物通过抑制细胞凋亡，从而发挥治疗作用。五、大鼠局灶性脑缺血12小时模型组缺血脑组织HSP70光密度值含量较正常组明显增高（p＜0.05）。珍珠母治疗脑缺血12小时组缺血脑组织HSP70光密度值较缺血12小时模型组无显著性差异（p＞0.05）。胆酸治疗脑缺血12小时组缺血脑组织HSP70光密度值较缺血12小时模型组无显著性差异（p＞0.05）。

12H treatment group compared with 12h model group: the density of light of nNos of the Gardenoside group decreased and P53 decreased with the model group; the density of light of the nNos of the Baicalin group decreased and which of the P53 is no different with the model group, the density of nNos of the Concha Margatitifera Usta decreased and which of P53 decreased than the model; the density of of nNos of the Cholic Acid group is no different and the density of P53 decreased than the model; the density of the light of nNos of the Hefang Group is no different and which of P53 decreased than the model group.

珍珠母治疗脑缺血24小时组缺血脑组织HSP70光密度值较缺血24小时模型组无显著性差异（p＞0.05）。胆酸治疗脑缺血24小时组缺血脑组织HSP70光密度值较缺血24小时模型组无显著性差异（p＞0.05）。栀子苷治疗脑缺血24小时组缺血脑组织HSP70光密度值较缺血24小时模型组明显增高（p＜0.01）。黄芩苷治疗脑缺血24小时组缺血脑组织HSP70光密度值较缺血24小时模型组明显增高（p＜0.01）。合方治疗脑缺血24小时组缺血脑组织HSP70光密度值较缺血24小时模型组无显著性差异（p＞0.05）。

Expression of nNOS mRNA, eNOS mRNA and iNOS mRNA in the E 20 cerebral cortex: There were no obvious changes of expression of nNOS mRNA in ETU-injected and control groups. Expression of eNOS mRNA increased significantly in cerebral cortex of the encephalocoele group, And there were no obvious changes of expression of eNOS mRNA in cerebral cortex of the control group and the other ETU-injection groups.

六、不同组E20胎鼠大脑皮质中nNOS mRNA、eNOS mRNA和iNOS mRNA的表达 1、实时定量PCR检测发现对照组、给药无畸形组、脊柱裂组和脑膨出组E20胎鼠大脑皮质中nNOS mRNA表达无明显改变； 2、给药无畸形组、脊柱裂组和对照组胎鼠大脑皮质中eNOSmRNA表达无明显改变，而脑膨出组胎鼠大脑皮质中eNOS mRNA表达明显增多； 3、在各组未检测到iNOSmRNA表达。

Of the 26 lesions with pontine and bulbar involvement, three had no association with other lesions (Fig 2). Twelve were associated with tegmental and superior cerebellar peduncular extension, and six showed corticospinal tract involvement in continuity with an MDJ lesion. In one patient with additional telencephalic lesions, the right side of the pons was hyperintense on long TR/TE images that did not cross the midline, suggestive of an arterial lesion (Fig 3). In two patients with pontine tegmental lesions, there was an associated middle cerebellar peduncle and deep cerebellar white matter involvement (Fig 4). Two others had associated cervical lesions.

在26处脑桥延髓区病灶中，3处病灶仅限于脑桥延髓区，其它部位无病灶（图2）；12处病灶还同时伴有背盖部和小脑上脚/结合臂处病灶；6处病灶为与中脑-间脑接合处病灶相连的皮质脊髓束受累；还有1例患者除端脑见病灶外，右侧脑桥于T2像也见高信号病灶，但未超越正中线，提示可能系动脉病变所致（图3）；2例脑桥背盖部病灶的患者同时伴有小脑中脚/小脑脑桥脚和小脑深部白质受累（图4）；还有2处脑桥延髓区病灶还同时伴有颈髓病灶。

There were no significant differences for the firing rates in the site of contralateral TNC neurons among during pre-CSD,CSD,and post-CSD (P＞0.05).For flunarizine group,the firing rates in the site of ipsilateral TNC neurons during pre-CSD were higher as compared with during CSD(P＜0.05).2.1 There were statistical differences on palasma levels of CGRP and SP among the three groups(P＜0.05).The levels of CGRP and SP in CSD group were higher than control group(P＜0.05).No significant differences on the levels of CGRP and SP in ipsilateral trigeminal ganglia were found among the three groups(P＞0.05).2 The number of neurons with positive CGRP and SP immunoreactivity was statistically different in right-sided trigeminal ganglia among the three groups (P＜0.05).The number in fight-sided trigeminal ganglia in CSD group was higher as compared with control group(P＜0.05).The number in right-sided trigeminal ganglia was statistically higher than that in left-sided trigeminal ganglion in CSD group(P＜0.05).3.1 Altered ReHo in ipsilateral pons and other brain regions response to pain such as basal nuclei,thalamus,cingulated gyms and prefrontal cortex was detected during the acute spontaneous attack as compared with during headache remission(P＜0.05,corrected by Monte Carlo simulation). 2 Positive functional connectivity was detected between ipsilateral pons and other brain regions related to pain within pain state and within non-pain state (P＜0.05,corrected by false discovery rate,FDR).Increased functional correlation between ipsilateral pons and other pain-related brain regions such as ipsilateral prefrontal cortex and contralateral subcallosal gyrus was detected during the acute spontaneous attack as compared with during headache remission(P＜0.05,corrected by Monte Carlo simulation).

结果1。对照组未发现CSD；同侧TNC放电频率，CSD中＞CSD后＞CSD前P＜0.05对侧TNC放电频率，CSD前、中、后无统计学差异(P＞0.05氟桂利嗪组同侧TNC放电频率，CSD前＞CSD中(P＜0.05)，CSD前与CSD后及CSD中与CSD后之间无统计学差异(P＞0.05)。2.1关于放免测定，各组血浆CGRP、SP水平有统计学差异(P＜0.05)，CSD组高于对照组(P＜0.05)，CSD组与氟桂利嗪组、对照组与氟桂利嗪组之间均无统计学差异P＞0.05各组之间同侧三叉神经节中CGRP、SP水平未见变化(P＞0.05.2关于免疫组化研究，右侧三叉神经节CGRP、SP免疫阳性细胞数三组之间有统计学差异(P＜0.05)，多重两两比较结果CSD组大于对照组(P＜0.05)，CSD组与氟桂利嗪组之间、对照组与氟桂利嗪组之间无统计学差异P＞0.05左侧三叉神经节CGRP、SP免疫阳性细胞数三组之间无统计学差异(P＞0.05CSD组中右侧三叉神经节CGRP、SP免疫反应阳性细胞数大于左侧(P＜0.05)。3.1局部一致性分析发现两组患者头痛疼痛状态较非疼痛状态脑活动发生变化的脑区有同侧脑桥以及其他疼痛相关脑区如基底节区、丘脑、扣带回、前额叶皮层等(P＜0.05，蒙特卡罗模拟校正)。2功能连接分析发现疼痛状态与非疼痛状态下主要疼痛相关脑区均与同侧脑桥有功能联系P＜0.05，false discovery rate，FDR校正疼痛状态与非疼痛状态比较，同侧前额叶皮层、对侧胼胝下回等疼痛相关脑区与同侧脑桥之间功能联系增强(P＜0.05，蒙特卡罗模拟校正。

Rnsults There were brain areas that distributing of radioactivity diminution in interictal SPECT in all 69 cases ,and there were brain areas distributing of radioactivity heighten in ictal SPECT in all 69 cases.

结论伽玛刀治疗脑软化灶导致的癫痫是有效的，而且无痛苦、无出血、无感染、无死亡、术后恢复快，其中以局限性发作效果最好；对脑软化灶导致癫痫的患者行SPECT检查，只有发作间期放射性分布减低和发作期增高在同一脑区才被确认为致痫灶；以上方法可明显缩小靶区体积。

Methods: 214 patients older than 65 years(the average age is 77.34 years) were selected from the clinic physical examination and hospitalized patients from July 2006 to December 2007. Allpatients didn't have any explicit nerve system organic diseases. 114 patients were confirmed as silent cerebral infarction by using cranial CT and/or MRI. Then the position and area of silent cerebral infarction as well as its relevant factors were analyzed.

2006年7月~2007年12月在干诊科住院及门诊体检的65岁以上老年患者214例，平均年龄为77.34岁，所有患者均无明确的神经系统病变，根据头部CT和头部MRI检查，明确114例为无症状脑梗死，分析无症状脑梗死的部位和大小以及无症状脑梗死相关的危险因素。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。