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The results showed that the inhibition of the ERK pathway in dHP resulted in anhedonia and anxiety-like behavior, and the ERK pathway inhibition in the mPFC induced anhedonia and locomotor impairment in rats.

但值得提出的是两个脑区ERK通路在对具体的抑郁行为表现的调节上存在一定的差异，如海马ERK信号阻断引起显著的焦虑行为反应而无活力水平的降低，而前额叶皮质ERK通路阻断则表现了活力降低而无焦虑行为，从而表现了一定的脑区特异性。

The results showed that the inhibition of the ERK pathway in dHP resulted in anhedonia and anxiety-like behavior, and the ERK pathway inhibition in the mPFC induced anhedonia and locomotor impairment in rats. The phosphorylation of the cyclic AMP-responsive-element-binding protein was decreased following the ERK pathway inhibition either in dHP or mPFC.

但值得提出的是两个脑区ERK通路在对具体的抑郁行为表现的调节上存在一定的差异，如海马ERK信号阻断引起显著的焦虑行为反应而无活力水平的降低，而前额叶皮质ERK通路阻断则表现了活力降低而无焦虑行为，从而表现了一定的脑区特异性。

And there were no evidence changes in histopathologic analysis of brain tissues in other ETU-injected and in control rat embryos. 2. Results of In situ cell apoptosis detection In E20 cerebral cortex, more Tunel cells were found in encephalocoele group than control group,and the results were significant.

二、应用细胞凋亡原位检测法检测不同组E20胎鼠大脑皮质中细胞凋亡情况 E20胎鼠大脑皮质中Tunel阳性细胞数目在正常组、给药无畸形组及脊柱裂组细胞凋亡数无明显改变，而在脑膨出组胎鼠大脑皮质细胞凋亡数明显多于对照组，计算凋亡细胞百分率，然后用X~2检验进行分析，脑膨出组和对照组的细胞凋亡指数差异有统计学意义(P.05)。

objective to explore the reasonable utilization of cephalosporins in chronic renal failure patients with cephalosporin encephalopathy.method we retrospectively analyzed the clinical characteristics of 29 crf patients,who developed encephalopathic syndrome and was treated with cephalosporin.results the encepha1opathic syndrome include (1)mental confusion in 4 cases;(2)unconsciousness in 2 cases;(3)seizure in 23 cases.physical examination did not show signs of cerebral focal injury.computed tomography of the brain in 29 patients did not show acute lesions.the state of neurotoxicity was completely recovered after discontinuation of cephalosporins.conclusion cephalosporins used in conventional doses or reduced doses can cause temporary encephalopathy in patients with crfwhich might due to prolongation of drug half life.

目的 通过研究慢性肾功能衰竭患者抗生素脑病的发病机制和临床特点，探讨头孢菌素在crf患者中的合理应用。方法 29例crf患者在使用常规剂量或减量使用头孢菌素后出现神经精神症状，诊断为抗生素脑病，将其临床资料进行回顾性分析。结果神经精神症状表现多样：(1)精神异常4例，表现为胡言乱语、烦躁不安、睡眠倒错；(2)意识障碍2例，表现为嗜睡、昏睡、神志不清；(3)癫痫样抽搐23例，表现为肌阵挛、全身抽搐、癫痫样发作；部分患者同时出现几组症状。所有患者均无神经系统定位体征，行颅脑ct检查无急性病变。

When multivariate logistic regression analysis was applied, only deep-seated AVM and a single draining vein were associated with presentation of hemorrhage. Small size, deep venous drainage and intranidal aneurysm did not independently correlate with hemorrhagic presentation.

进一步多因素logistic回归分析结果显示，只有深部脑AVM和单一静脉引流与脑AVM出血相关，小型脑AVM、深静脉引流和畸形血管团内动脉瘤与脑AVM出血无独立相关性。

By univariate analysis, deep-seated AVMs, small AVMs, deep venous drainage , a single draining vein and intranidal aneurysm were associated with hemorrhagic presentation. There was no statistically significant relationship between gender, age, type of arterial feeders, type of nidus, stenosis of draining vein and AVM hemorrhage.

单因素分析表明，深部脑AVM、小型脑AVM、深静脉引流、单一静脉引流和畸形血管团内动脉瘤与脑AVM出血相关，性别、年龄、动脉血供类型、畸形血管团类型和引流静脉狭窄与脑AVM出血无相关性。

The expression level of FLK1 mRNA was lower (P.01) at 12 h after MACO in DMCI group than that in NDMCI group. Except for at 6 h, there was no significant difference between DMCI and NDMCI group in the expression level of FLT1 mRNA.

结果 DMCI组在脑缺血后各时间点脑缺血半暗带等值区VEGF mRNA的表达水平均显著低于NDMCI组（P.05～0.01），FLK1 mRNA 表达水平在脑缺血后12 h显著低于NDMCI组（P.01），FLT1 mRNA 表达水平在脑缺血后各时间点（除6 h）与NDMCI组差异无统计学意义。

Results The expression level of VEGF mRNA was lower in DMCI group than that of NDMCI group at every time point (P.05 ～ 0.01). The expression level of FLK1 mRNA was lower (P.01) at 12 h after MACO in DMCI group than that in NDMCI group. Except for at 6 h, there was no significant difference between DMCI and NDMCI group in the expression level of FLT1 mRNA.

结果 DMCI组在脑缺血后各时间点脑缺血半暗带等值区VEGF mRNA的表达水平均显著低于NDMCI组（P.05～0.01），FLK1 mRNA 表达水平在脑缺血后12 h显著低于NDMCI组（P.01），FLT1 mRNA 表达水平在脑缺血后各时间点（除6 h）与NDMCI组差异无统计学意义。

Neurogenesis and development of the central nervous system in the embryo stage of swimming crabs, Portunus trituberculatus, were studied by the histological method.

应用组织学方法研究三疣梭子蟹胚胎期中枢神经系统的发生和发育，光学显微镜下镜检切片，在第二期卵内无节幼体阶段开始观察到脑；第二期卵内状幼体阶段，前脑由视神经层、侧原脑和中央原脑组成，与位于食道两侧的中脑和后脑形成完整的脑。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。