无结果的

The results indicated that the thermosensitivity of PNIP/AAm nanogels couldn't be destroyed by drug-loading.

结果表明，药物分子对PNIP/AAm纳米凝胶的温敏性无影响。

Results: the 1-,3-,and 5-,year survival rates in the hepatectomy group were 79.5%,47.5%and 36.1%,the 1-,3-,year survival rates were 56.2% and 33.8% in hifu group,the 1-,3-,5 -,year survival rates in intervention group were 49.8%,22.4% and 4.5%, the patients who received absolute alcohol have survived for more than 3 years.

结果：肝切除患者1、3、5年生存率分别为79.5%，47.5%和36.1%，介入治疗者1、3、5年生存率分别为49.8%、22.4%和4.5%，hifu治疗的1、3年生存率为56.2%和33.8%，无水酒精注射治疗组存活5年以上者3例，存活3年以上者5例。

Single course of action. If he remains unsatisfied about acritical matter, he has no choice but to resign.

择管道，若是他对于特定事情的处理结果不满意，他还是只能辞职而别无其他选

Transcriptional activity of ACL recombinants normalized by Renilla was significant difference with pGL3-Basic expect for construct -27 and -15 (P＜0.01). Construct -919 contains highest activity. 3 times reduction of transcriptional activity from-919 to -679bp indicated that negative regulation factors located probably in this region. The activity started on construct -73 suggested the basal promoter activity was located within the -73 to +77bp region; Transcriptional activity of IDHβrecombinants was not significantly different between the recombinant -58 and pGL3-Basic. The activity started on construct -82, decreasing with the length of the fragment up to -164 in despite of a bit of fluctuation, and kept increasing from construct -164 up to -279. Thus, the basal promoter activity was located within the -82 to +16bp region, whereas the upstream 197bp conferred maximal transcriptional activity.

采用5'端缺失策略，结合启动子预测结果，分别构建了8个ACL基因和19个IDH3β基因启动子区重组子，将其转染猪PK15细胞系，并利用荧光素酶双报告基因系统检测了它们的活性，结果表明：在所构建的猪ACL基因5侧翼序列的8个重组子中，除pGL-ACL27和pGL-ACL15外，其它重组子的荧光素酶活性与阴性对照均达到极显著水平(P＜0.01)，表明它们均具有启动子活性，pGL-ACL919活性最强，到pGL-ACL679活性下降了将近3倍，说明从-919bp到-679bp区域可能存在负的调控位点，从pGL-ACL621到pGL-ACL73活性有小幅度下降，到pGL-ACL27活性降到与阴性对照水平无显著差异，表明维持该启动子的基本活性区域位于-73bp到+77bp之间；IDH3β基因启动子活性开始于pGL-IB82，然后虽然有些波动，但是活性一直下降直到-164bp处，之后活性又开始升高，直到-279bp处活性达到最高，这些表明维持该启动子的基本活性区域位于-82bp到+16bp之间，从-82到-279之间的179bp区域具有最高的启动子活性。

In the present paper, the Sox gene expression analysis of different tissues from the Trionyx sinensis was studied by using RTPCR, and Sox gene fragments of expression from the testicle, brain and spleen were cloned using RTPCR products. The results show that Sox gene has specific expression in the testicle, brain, spleen, cardiac muscle and kindney and hasn't expression in muscle, liver and ovary. The results of clone reveal that the Sox genes of expression in the testicle are TSSox1 and TSSox 4, and those are TSSox2 and TSSox4 in the brain, and that is TSSox4 in the spleen. This suggests that the Sox gene act important role not only on the sex determination, but also on the development of neural system, immunocyte system and the differentiattion of male germ cell.

本文采用RT—PCR技术，研究了中华鳖不同组织Sox基因的表达，并通过PCR直接克隆法，分析了来自睾丸、脑和脾组织中的Sox基因序列结果表明在中华鳖的成体组织中，Sox基因在脑、心肌、肾、脾和雄性的睾丸组织中均有不同程度的表达，而在肌肉、肝脏和雌性的卵巢中则无表达，显示该基因具有组织表达特异性克隆分析显示，在睾丸组织中表达的是TSSox1和TSSox4基因，而在脑组织中表达的是TSSox2和TSSox4基因，脾组织中表达的是TSSox4基因此结果表明Sox基因不仅在性别决定中起作用，还可能在神经系统、免疫系统多种组织中起重要作用

in 2950 subjects,including 1472 hbsag positive patients and 1478 hbsag negative control, all of them were obversved in 10 years and the standardized mortality ratio of primary carcinoma of liver were calculated in each group.results:①in hbsag positive groups,the smr were 8.85 in men and 12.50 in women,in hbsag negative groups, the smr were 2.87 in men and 3.40 in women, there were significant difference among different groups;②the trend of correlation between hbsag and primary carcinoma of liver were alike in 5 years before and after;③there were not any significant difference observed about the smr of carcinoma ventriculi and esophagus cancer in different groups.

采用前瞻性研究，自1996年7月起对观察对象随访10年，其中hbsag阳性者1472例，阴性者1478例，于2006年10月用流行病学方法分析各种标化死亡比等观察结果。结果：①hbsag阳性组的肝癌标化死亡比男、女分别为8.85与12.50，hbsag阴性组的肝癌smr分别为2.87与3.47，两组之间差异显著；②hbsag与肝癌的关系在前后5年的趋势相似；③hbsag阴性和阳性组的胃癌及食道癌的标化死亡率无统计学差异。

The study and comprehensive analysis of static high-pressure quenching experiments and laboratory dynamic high-pressure experiments on chondrites,as well as the study of shock-induced phase transition of minerals in the Suizhou meteorite revealed that the P-T conditions for phase transition of minerals during natural impact events,such as collision of cosmic bodies or impact of meteorites on the Earth′s surface,are not consistent with those obtained by shock experiments on chondrites or rocks in laboratory,...

通过对球粒陨石的静态高压淬火实验和人工动态高压实验的研究和综合分析，以及对在太空中经受过撞击的随州陨石中矿物发生高压相变的研究，查明了自然界的冲击事件，如星体的相互碰撞和陨石对地球表面的撞击中，矿物发生相变的P-T条件与人工冲击波实验的结果并不一致，而与静态高压淬火实验的结果相似，即前者类似静态高压淬火实验，保压时间较长，能产生高压矿物，后者保压时间极短，无高压矿物形成。

The simulation results of the cylinder-block model were given in the article, consistent with that of Middlemen"s. It was shown that the block part could improve the uniformity of the flow distribution. The analysis of the flow field of some materials with different power-law factor in the die designed by Mckelvey was close to that of Mckelvey"s. It was shown that the flow distribution was uniform in the die that can producesheets with 1200mm in width. During the analysis the flow channel was divided into several parts to get the details about the fluid flow in each area. A conclusion was drawn after analyzing the influence of the die pressure on the flow distribution, that the higher pressure is good for the output and bad for the uniformity of the distribution. Simulation of the die applying the cylindrical main runner showed the fact that when the cylinder replaced the cone the change of uniformity was trivial. The uniformity of the non-block flow channel was so poor that the block in the proper position of the die channel was necessary. The project of the die for the wider sheet was put forth, and the analysis of the fluid flow in the die was shown.

本文模拟了圆柱管缝隙流模型的三维流动场，得到了与Middlemen结论一致的流动均匀性，并通过模拟直观地展示了采用阻尼块可以改善挤出均匀性的现象；分析了多种幂率指数的流体在Mckelvey等人设计的流道模型中的流动分布，得到了与Mckelvey的分析结果接近的压力降和流量偏差；本文建立了1200mm幅宽机头流道的三维有限元模型，并逐个分析各个区域和多个截面的流动分布状况，由此揭示了1200mm幅宽L-型机头流道内的流北京化工大学硕士学位论文动分布基本均匀，并在分析了机头压力对于挤出流动分布的影响后得出结论：较高的机头压力可以获得较大的产量，但是不利于物料均匀分布；模拟了采用圆柱管主流道时机头流道内的流动分布，得出结论：主流道由圆锥管改为圆柱管时对流动均匀性影响不大，通过设置适当的阻尼仍然可以达到挤出平衡；模拟了两端进料式圆柱管无阻尼流道的流动均匀性后得到结论：两端进料式无阻尼结构的流动均匀性较差，宽机头中仍然有必要设置阻尼块；确定宽幅机头流道的基本方案，并设计了一种宽幅防水卷材挤出机头流道的结构，通过流动模拟表明该种结构的流动均匀性较好；考察了宽幅机头对于不同厚度片材的挤出适应性，得到结论：当生产不同厚度的片材时，阻尼块高度需要调整。

For ozonolysis, the SOA yield has not been changed by inorganic seed aerosol, because the products are mainly carboxylic acids, which has much lower saturation vapor pressure and thus easily undergo homogeneous nucleation or gas-particle partitioning to be in the aerosol phase.

而对于α-蒎烯臭氧氧化的过程，实验结果表明，干态硫酸铵颗粒物种子的存在对SOA产率无影响，对臭氧氧化生成的SOA分子鉴别的结果表明，可鉴别组分中有很高比例的有机羧酸类物质，这一比例远高于光氧化产物，这些有机酸具有较低的挥发性而极易形成颗粒相，并且不参与异相酸催化反应。

The results showed that (1) COX-2 mRNA and protein existed in the mature male rat testis. COX-2 was localized in spermatocytes by immunohistochemistry.(2) COX-2 also existed in adult man testis. COX-2 protein was positively stained in spermatocytes and Leydig cells.(3) 2 weeks after administration of rofecoxib, the level of testosterone in the whole testis reached its lower values, being only 50% of control values. However, testosterone level recovered during 4 weeks. After such treatment, histologic examination of these testes showed atrophy of the seminiferous tubules and maturation arrest of spermatogenesis.(4) 2 weeks post-EDS, expression of COX-2 decreased significantly (P.005), in comparison with vehicle-treatment control. 4 weeks after treatment, a new generation of fetal like Leydig cells repopulated in the testicular interstitium resulting in COX-2 expression partially recovered. Although the expression of COX-2 mRNA and protein are enhanced at 8th week after using external testosterone, it wasn't significant higher than control group.

实验研究证明：(1)正常成年雄性大鼠睾丸组织中COX-2在mRNA和蛋白质水平均存在表达，免疫组织化学结果显示COX-2定位于曲细精管内的生精细胞；正常成年男性睾丸组织中同样存在COX-2表达，免疫组织化学结果显示COX-2定位于曲细精管内的生精细胞和Leydig细胞；(2)服用特异性COX-2酶抑制剂rofecoxib 2周后，实验组大鼠睾丸组织内睾酮的含量减少，为正常对照组的50％；持续用药4周后睾丸组织内睾酮浓度逐渐恢复至正常水平；COX-2酶活性降低后病理组织切片显示睾丸内曲细精管萎缩，生精紊乱，持续用药4周时影响最明显；(3)注射特异性Leydig细胞杀灭剂EDS 2周后，实验组大鼠睾丸组织内睾酮浓度降至极低水平时，COX-2的蛋白和基因表达水平也显著低于正常空白对照组（P.005）；使用EDS后第4周，睾丸组织中的睾酮浓度逐渐回升，同样组织中COX-2蛋白表达和mRNA表达水平也相应提高接近正常水平；使用EDS后4周开始给予外源性睾酮，6周和8周时COX-2表达水平的绝对值虽有提高，但与正常大鼠空白对照组比较并无显著性差异，说明外源性雄激素刺激睾丸合成COX-2的作用并不明显。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。