无结果

Results showed:(1) The airway responsiveness of smoke control group was higher than that of normal control group, the airway responsiveness of smoke + exercise group was lower than that of smoke control group;(2) Plasma level of cortisol determined immediately after exercise was higher than that determined before exercise, no significant difference occurs between that determined next day morning after all exercise finished in contrast to that determined before exercise;(3) HE staining showed, there was severe chronic pulmonary inflammatory response in smoke control group, which was reduced in the smoke + exercise group;(4) chronic cigarette smoke downregulated the protein and mRNA expression of BKca in smooth muscles of bronchi and bronchioli, exercise increased the mRNA expression of BKca;(5) chronic cigarette smoke downregulated the protein and mRNA expression of Kv1. 5 in smooth muscles of bronchi and bronchioli, exercise increased both the protein and mRNA expression of Kv1. 5 in contrast to smoke control group in bronchioli and did not effect the expression of Kv1. 5 in bronchi;(6) chronic cigarette smoke induced upregulation of FIZZ1/RELMα in bronchial smooth muscle cells, exercise decreased these effect.

结果：(1)吸烟对照组的气道反应性明显增高，吸烟加运动应激可明显降低大鼠的气道反应性；(2)吸烟运动组运动后血浆皮质醇浓度明显高于运动前，但全部运动结束后次日晨测定的血浆皮质醇浓度与运动前无明显差异；(3)HE染色显示，吸烟对照组肺组织出现明显的慢性炎症反应，吸烟加运动应激组比吸烟对照组炎症反应轻；(4)慢性吸烟可降低大鼠大气道和小气道BKca mRNA和蛋白表达，而吸烟加运动应激可使BKca mRNA表达上调，但对小气道的蛋白表达无影响；(5)慢性吸烟可降低大鼠大气道和小气道Kv1.5蛋白和mRNA表达，在小气道吸烟加运动应激可减轻这种作用，大气道则无作用；(6)吸烟使支气管平滑肌的FIZZ1/RELMα蛋白表达明显增强，而吸烟加运动组的RELMα蛋白及mRNA均明显减弱。

Plantlet regeneration from cotyledon of Citrullus lanatus cv. Zhangkang No. 4 was studied. The results showed that aseptic seedlings should be cultured in dark for 3d, then exposed to a photoperiod of 16/8h/d for 3d. The callus induction rate was higher in cotyledons placed facing downwards to the medium than in those facing upwards. The highest induction rate occurred in MS medium containing 6-BA (2.0mg/L), kinetin (1.0mg/L)and GA3 (1.0mg/L). The induction initiated in dark and took 7 days, while callus growth and differentiation proceeding for 7 days under 16/8h light-dark cycles. A highest rate of embryogenic callus was obtained after 3 successive subcultures.

以无子西瓜郑抗4号无菌苗子叶为外植体，进行了体细胞胚发生及植株再生的研究，结果表明，无菌苗应先进行3d暗培养，然后采取光照16h/d和黑暗8h/d培养3d；将子叶的叶面朝下放置于培养基上的愈伤组织诱导率高于叶面朝上的培养方式；子叶诱导胚性愈伤组织的最适培养基配方为MS+6-BA2.0mg/L+KT1.0mg/L+GA31.0mg/L；诱导需要在黑暗条件下启动，进行7d暗培养，而生长分化于光照16h/d和黑暗8h/d条件下培养7d；继代3次得到的胚性愈伤组织最多；最适生根培养基配方为1/2MS+IBA0.3mg/L。

Let's live cozily in the profound and boundless Tao.

不要浪费时间在与人争论上，因为那是没有结果的，就让我们安稳地生活在深广无涯的道中吧！忘年忘义，振于无竟，故寓诸无竟。

Six weeks after drug intervention,we found,in ADM+Res group,the mean tumor volume of MCF-7/ADM cells implanted tumor was 1.203±0.338 cm~3 with statistical significance to compare with other groups(P＜0.05),decreased about 50.58%compared with the mean tumor volume of ADM alone group1.979±0.307 cm~3the result of the mean tumor weigh was alike to the mean tumor volume; compared with the control,Res could relieve weigh loss(P＜0.05,and the toxicity of treatment was not obvious;Microscopic examination showed that there was massive area of cytoclasis and apoptosis in the tumor tissue of the combination group comparing with other groups.

实验结果提示用药6W后，ADM+Res组移植瘤体积(1.203±0.338)cm~3明显小于其余各组，抑瘤率为50.58%，与单用ADM组(1.979±0.307)cm~3相比有差异P＜0.05肿瘤重量的结果与瘤体结果类似；未观察到用药后的毒副作用；经不同处理后，单独注射Res组小鼠体重较生理盐水组及ADM组有所增加(P＜0.05，而ADM+Res组治疗前后体重无差异P＞0.05HE结果显示与其他组相比，ADM+Res组肿瘤组织中出现大片坏死区域。

Results l.Serum concentrations of VCAM-1 in PIH (93.39 + 57.3)ug/ml were higher than that in normal pregnant group. Serum concentrations of VCAM-1 in moderate(97.89 + 34.07)ug/ml and severe PIH(132.24 + 60.97)ug/ml were significantly higher than that in normal group.(P.05, P.01). There was no difference between serum levels of VCAM-1 mild PIH and normal pregnant group. 2.Serum levels of IL-6 in PIH group(102.17 ?48. 31)pg/ml were significantly higher than that in normal group(49.16 + 12.9)pg/ml.Serum levels of IL-6 in moderate(95.79+31.19)pg/ml and severe PIH( 127.27+11.3 8)pg,ml were significantly higher than that in normal group. There was no difference between serum levels of PIH in mild PIH (52.13 + 12.90)pg/ml and normal pregnant group. 3. In PIH group, serum concentrations of VCAM-1 correlate with the levels of IL-6,r=0.63. 4.The expression of VCAM-1 in cytotrophoblast of spiral arteries in normal pregnant group(100%) were significantly higher than that in PIH group.Theexpression of VCAM-1 in moderate PIH(37.50%) and sever PIH were lower than that in normal group.There was no difference between the mild PIH and normal group.Conclusions The increased levels of serum of VCAM-1 may participate in the process of vascular endothelium damages in PIH.

结果 1、妊高征组血清VCAM-1浓度为(93.39±57.3)μg／ml明显高于正常妊娠组(44.87±15.60)μg／ml，差别有显著性(P＜0.05)；中、重度妊高征组VCAM-1浓度分别为(97.89±34.07)μg／ml和(132.24±60.97)μg／ml，与正常妊娠组比较，差异有显著性(p＜0.05)和非常显著性(P＜0.01)；轻度妊高征组VCAH-1为(48.46±15.60)μg／ml与正常妊娠组比较，差异无显著性(P＞0.05)。2、妊高征组血清IL-6含量为(102.17±48.31)pg／ml，明显高于正常妊娠组(49.16+12.9)pg／ml，差异有非常显著性(P＜0.01)；中、重度妊高征组IL-6含量分别(95.79±31.19)pg／ml和(127.27±11.38)pg／ml，与正常妊娠组比较，差异有显著性(P＜0.05)和非常显著性(P＜0.01)；轻度妊高征组IL-6含量为(52.13±12.90)pg／ml与正常妊娠组比较，差异无显著性(P＞0.05)。3、VCAM-1与IL-6水平呈明显正相关，r=0.63(P＜0.01)。4、子宫胎盘床螺旋动脉滋养细胞VCAM-1表达，正常妊娠组都存在阳性表达(阳性表达率100％)，妊高征组有10例阳性表达阳性表达率为叩们，差别有非常显著性河＜0.01L 中、重度妊高征组阳性表达率分别为37、50％和0，与正常妊娠组比较，差别有显著性河＜0.05）和非常显著性汀＜0.01太轻度妊高征组阳性表达率为83.33凡与正常妊娠组差别无显著性问＞0.05）。

The development of the lead free cutting brass containing bismuth and graphite/copper composite was summarized.It can be concluded that the key points for cutting brass containing no lead are the choices of elements which can form brittle but not hard intermetallics and procedure which can make the intermetallics distribute dispersively.

详细介绍国外无铅易切削铋黄铜研究开发的一些成果和石墨/铜合金复合材料的研究情况，总结国内无铅易切削铜合金的研究情况，结合自己的研究结果，指出无铅易切削铜合金的研究方向是采用适当的元素形成脆而不硬的金属间化合物，并采用一定的加工手段使其呈弥散分布。

Results are as followed:1 Exposure of HELF cells to BP caused c-Jun activation,and increased the activity of MAPK,PI-3K,p53 and cyclin D1 pathway.2 BP-induced c-Jun activation was inhibited by dominant negative mutants of extracellular signal-regulated protein kinase or c-Jun NH_2-terminal kinase,but not by p38,impling that JNK and ERK pathways medicate c-Jun activation induced by BP.3 Overexpression of dominant-negative mutants PI-3K and Akt potently blocked phosphorylations of c-Jun and ERK,but not JNK in response to BP,suggesting that PI-3K/Akt pathway positively regulates BP-induced c-Jun activation through ERK.4 Inhibition of p53 by its chemical or molecular inhibitor markedly increased the phosphorylation levels of c-Jun,Akt and ERK upon BP stimulation,indicating that p53 negatively medicates BP-induced c-Jun activation through PI-3K/Akt/ERK pathway.5 The cell lines expressed TAM67 exhibits no significant affecting normal cell growth properties.6 TAM67 was able to significantly block G_1-S transition and subsequent cell proliferation,suggesting that c-Jun is essential for cell cycle alternations elicited by BP.7 Overexpression of TAM67 impaired BP-induced cyclin D1 activation,decreasing expression of E2F1 and pRb,indicating that c-Jun participates in the modulation of BP-induced activation of cyclin D1/pRb/E2F1 pathway.8 Stably expression of TAM67 led to the increases in the expression levels of p53 and p21,elevating phosphorylation level of p53,clearly indicating that c-Jun regulates p53/p21 pathway activation induced by BRCollectively,PI3K/Akt/ERK pathway mediated BP-induced c-Jun activation through p53-dependent mechanism.

结果显示：1BP刺激细胞可促进c-Jun活化，并伴随着MAPK、PI-3K、p53和cyclinD1通路各组成成分的活性增强。2利用MAPK通路的显性失活突变体分别阻断细胞外信号调节激酶和c-Jun氨基末端激酶活性，均可明显抑制BP诱导的c-Jun活化，但阻断p38活性对BP引起的c-Jun活化无明显影响，提示JNK和ERK通路参与调控BP诱导的c-Jun活化。3过表达PI-3K和Akt的显性失活突变体也可显著抑制BP诱导的c-Jun活化，并降低磷酸化ERK的表达水平，但对磷酸化JNK的表达水平无明显影响，说明PI-3K/Akt通路通过ERK正性调控了BP诱导的c-Jun活化。4p53的化学/分子抑制剂能使BP作用的细胞内c-Jun活性明显增加，并同时诱导Akt和ERK的磷酸化水平的升高，表明p53可通过PI-3K/Akt/ERK通路对BP诱导的c-Jun活化进行负性调控。5随后观察转染细胞的生长情况，发现TAM67对细胞正常生长和形态无明显影响。6稳定表达TAM67可有效抑制BP诱导的S期细胞数的增加，提示c-Jun在BP致细胞周期改变的过程中发挥了重要作用。7TAM67过表达能够抑制BP诱导的cyclin D1活化，降低磷酸化Rb以及E2F1蛋白表达水平，表明c-Jun参与调控BP诱导的cyclin D1/Rb/E2F1通路的活化。8过表达TAM67可使BP刺激的细胞中p53、p21总蛋白以及p53磷酸化的表达水平明显升高，可见c-Jun也参与调控BP诱导的p53/p21通路活化。

The results were expressed in mean±1SD. Pearson X~2 test and One-way ANOVA test were used. The data analyzed using the SPSS (version 11.5). Results: The sensitivity, specificity, positive and negative value of US for the LPEH model on the children cadaver were 88%, 84%, 79%, 91%, respectively. With regard to the thickness of femora head cartilage, the thickness of the anterior layer or posterior layer, there were no significant differences among three groups. However, the anterior layer was thicker than the posterior layer in three groups. The fluid in hip joint was detected in all of 21 symptomatic hips, which was clear commonly (90%) in early procedure. The amount of fluid in anterior recess showed a positive correlation with age (p .05). No fluid was detected in the asymptomatic and normal hips (2mm). The mean maximum width of inferomedial recess was significantly larger than that of anterior recess (12.50±4.04mm vs.4.35±0.8mm, p 0.05) in the symptomatic hip joints. The echogenic entrapped labral plicaes were demonstrated in the inferomedial recess in all of 21 children with LPEH, whose length and width ranged from 5.3mm-25.0mm (mean,15.6±5.6mm) and from 4.0mm-17.0mm (mean,8.9±7.8mm).

结果1，尸体LPEH髋关节模型的超声诊断敏感性、特异性分别为88％、84％，阳性预测值、阴性预测值分别为79％、91％。2，21例患儿的LPEH患髋(21侧)、健髋(21侧)，以及21例正常儿童健髋(42侧)的超声检查显示：髋关节周围软组织及股骨头无形态结构差别；股骨头软骨厚度无统计学差异(3.5±0.5mm vs.3.6±0.4mm vs.3.6±0.5mm，p＞0.05)；关节囊前层及后层厚度无统计学差异(前层厚度2.79±0.74 mm vs.2.56±0.40mm vs.2.56±0.72mm；后层厚度2.70±0.82mm vs.2.48±0.54mm vs.2.44±0.58mm，p＞0.05)，但LPEH患髋关节囊前、后层均较后二组有增厚趋势。3，LPEH患髋均存在关节腔内积液，且早期较为清晰；积液以髋关节内下间隙明显，内下间隙较前间隙明显增宽(12.50±4.04mm vs.4.35±0.8mm，p＜0.05)，其内见嵌顿滑膜唇皱襞呈稍强回声的占位性团块，长约15.6±5.6mm，宽约8.9±7.8mm，90.5％(19／21)嵌顿皱襞内未见血流信号。4，所有LPEH患髋治疗后超声复诊均显示正常。

Results: In acute experiment, there was no significant difference of body weight or organ indexes between the normal control and arsenic poisoning groups ; while the CH50 level, lymphocyte accruing rate, phagocytosis rate and macrophagocyte index in arsenic poisoning group were significantly lower (P.05 or P.01) than those in normal group. There was no significant difference of body weight or organ index between arsenic poisoning group and EXD (10 g) treated arsenic poisoning group, while CH50, lymphocyte accruing rate, phagocytosis rate, and mavrophocyte index were significantly higher in EXD (10 g) treated arsenic poisoning group than those in arsenic poisoning group (P.05 or P.01). In EXD (5 g) treated arsenic poisoning group, results of all the tested indexes were the same as those of arsenic poisoning group.

结果：与正常对照组相比，砷中毒组小鼠体重、脏器指数无明显改变；CH50、淋巴细胞增殖、巨噬细胞吞噬率及吞噬指数明显降低，差异有显著性（P.05或P.01；与砷中毒组相比，竹荪治疗低剂量组小鼠体重、脏器指数、CH50、淋巴细胞增殖、巨噬细胞吞噬率及吞噬指数无明显改变化；竹荪治疗高剂量组除小鼠体重、脏器指数无明显改变外，CH50、淋巴细胞增殖、巨噬细胞吞噬率及吞噬指数明显升高，差异有显著性（P.05或P.01）。

Ki-67 and Pgp expressions were measured by immunohistochemical analyses on multiple nonconsecutive sections from surgery or biopsy specimens of breast cancers.

结果：11位具有Ki-67表现乳癌病患，其肿瘤－背景比值明显高於13位无Ki-67表现者(4.26±0.41对2.25±0.33，P＜0.05)，然而8位具有P-醣蛋白表现及16位无P-醣蛋白表现，其肿瘤－背景比值则无明显差异(3.52±0.40对3.42±0.45，P＞0.05)。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。