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In aspermous Patients the reason is the obstruction of spermatogenesis, the most common obstruction occurs in the spermatid level.

无精症患者中是由生精阻滞所致,最常见的阻滞发生在精子细胞水平。

The result is: out of 187 cases of azoospermia, 77(41.18%)patients with abnormal chromosome(number and structural aberration); heteromorphic chromosome(Y chromosome polymorphisms and pericentric inversion of 9) and 46,XX sex reversal. Out of 30 cases of severe oligospermia, 4 patients with abnormal chromosome(structural aberration and 46,XX sex reversal).

发现187例无精症患者中检出异常核型77例(41.18%)(其中46,XY,t(6;14)(p21;p13),46,XY,t(8;12)(p21;q24)为世界首报核型),主要涉及染色体异常;染色体异态(Y染色体异态和9号染色体臂间倒位)及46,XX性反转;30例严重少精症患者中检出异常核型4例(13.33%)(结构异常和46,XX性反转)。

The spermatogenic states of 38 azoospermic men were evaluted use fine needle aspiration cytodiagnosis and bioptic gun testicular tissue pathologic assessment.

一、用细针抽吸细胞学检查和活检枪穿刺组织学检查的方法,对38例无精症病人的睾丸生精功能进行了评价。

Results The diagnostic correspondent rate of obstructive and nonobstructive azoospermia by seminal spermatogenic cells examination was 85%, 95.1% respectively. The spermatogenic arrest at spermatid level, spermatocyte level and spermatogonium level or sertoli cells only were 14, 21 and 6 cases respectively.

结果 精液生精细胞学检查对梗阻性和非梗阻性无精症分型诊断的符合率分别为85%、95.1%。41例非梗阻性无精症中,生精阻滞阶段在精子细胞、精母细胞、精原细胞分别为14例2、1例和6例。

In recent years, many kinds of diseases were found have relationship with CAG polymorphism in AR gene, such as hyperplasia of prostate, carcinoma of prostate, male oligospermia and aspermia, female breast cancer, endometrial carcinoma, male breast cancer, et al.

近年来发现多种与雄激素有关的疾病如前列腺增生、前列腺癌、男性少精无精症、女性乳腺癌、子宫内膜癌、男性乳腺癌等与AR基因CAG重复多态性有关。

Objective To investigate the applied value and clinical value of classification diagnosis on azoospermia by seminal spermatogenic cells examination.

目的 探讨精液生精细胞检查对无精症诊断的应用价值及临床意义。

Objective To investigate the clinical value of the determinations of serum sex hormone in the patients with oligospermia and azoospermia.

目的 探讨少精、无精症患者血清性激素检测的临床应用价值。

Chromosomal abnormality and DAZ gene deletion are closely related to the spermatogenesis impediment, and they are important reasons for azoospermia and oligospermia.

染色体异常和DAZ基因缺失与生精障碍密切相关,是无精、少精的重要原因。

Methods Serum sex hormone levels of 21 patients with azoospermia, 48 patients with oligospermia (there were 13 patients with severe oligospermia in them) and 25 healthy men with normal semen as normal control were determined by chemiluminescent immunoassay.

方法采用化学发光免疫分析法测定21例无精症、48例少精症(其中13例为重度少精症)患者与25例精液正常的健康体检男性的血清性激素水平。

Ninety-three patients with forty-two azoospermia and fifty-one severe oligozoospermia were recruited in present study. Y chromosome microdeletions were screened by detection of four locus SY84, SY134, SY255 and SPGY1 gene spaning the AZFa, AZFb and AZFc subregions of Y chromosome. The total incidence of Y microdeletions was 16%( 15/93 )in present study. Eight men in 42 patients with azoospermia had Y microdeletions, of whom 6 were AZFc deletion and 2 were AZFb deletion.

通过对93例男性不育(42例无精症和引例严重少精症)患者,Y染色体 SPGY基因、AZFa-SY84、AZFb-SY134和 AZFc-SY255位点缺失情况的研究,我们发现男性不育患者 Y染色体微缺失的发生率为 16%( 5旧3人 42例无精子症患者中,有8例存在Y染色体微缺失,其中6例为AZF。

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