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Fund Project: the National Natural Science and Technology Source Program, No. 2001DEA1006*Abstract: Number of neural stem cells is small. NSCs look like circle or ellipse with or without short neurite, with large nuclear-cytoplasmic ratio and deep karyotin. NSCs have no visible differences with other kinds of cells in appearance, and have no cell surface marker. Currently, there are mainly three aspects to identify NSCs: expression of specific nerve antigen, including nestin, Musashi, transcription factor, and cell adhesion molecules; self-renewal ability including single cell clone analysis, BrdU mark and S phase cell; the potential of multi-direction differentiation including immunocytochemical process and reverse transcriptase polymerase chain reaction.

由于神经干细胞的数量很少,从细胞形态来看神经干细胞为圆形或椭圆形,无或有较短的突起,核质比大,核染色较深,形态上与其它种类的细胞没有明显的差异,并且未找到一种细胞表面特异性标志物,因此目前鉴定神经干细胞主要有以下3个方面:特异性神经抗原的表达,包括巢蛋白、Musashi、转录因子及细胞黏附分子;自我更新能力,包括单细胞克隆分析、BrdU标记S期细胞;多向分化潜能,包括免疫细胞化学法、聚合酶链反应色法。

Number of neural stem cells is small. NSCs look like circle or ellipse with or without short neurite, with large nuclear-cytoplasmic ratio and deep karyotin. NSCs have no visible differences with other kinds of cells in appearance, and have cell surface marker. Currently, there are mainly three aspects to identify NSCs: expression of specific nerve antigen, including nestin, Musashi, transcription factor, and cell adhesion molecules; self-renewal ability including single cell clone analysis, BrdU mark and S phase cell; the potential of multi-direction differentiation including immunocytochemical process and reverse transcriptase polymerase chain reaction.

由于神经干细胞的数量很少,从细胞形态来看神经干细胞为圆形或椭圆形,无或有较短的突起,核质比大,核染色较深,形态上与其它种类的细胞没有明显的差异,并且未找到一种细胞表面特异性标志物,因此目前鉴定神经干细胞主要有以下3个方面:特异性神经抗原的表达,包括巢蛋白、Musashi、转录因子及细胞黏附分子;自我更新能力,包括单细胞克隆分析、BrdU标记S期细胞;多向分化潜能,包括免疫细胞化学法、聚合酶链反应色法。

An algorithm based on the square-root unscented Kalman filter is proposed for weight estimation of the neural network, which can overcome the BP algorithm's drawbacks of slow learning speed, high computational complexity and the likeliness to make the study fall into the local minimum points.

提出一种利用平方根无轨迹卡尔曼滤波进行神经网络权值估计的算法,该算法可以克服BP算法存在的学习速率缓慢、计算量大、容易使学习陷入局部极小等缺点以Mackey-Crass混沌时间序列作为神经网络输入,运用SR-UKF算法、UKF算法、BP算法仿真神经网络。

The ultrastructure studies show that the number of mitochondria in the motor neurons from resistant strain are higher than those of the susceptible strain, and the thickness of neural lamella and perineurium of resistant strain is thicker than those of the susceptible insects.

棉铃虫抗性种群、对照种群、同种群不同龄期幼虫以及同一个体胸、腹神经节的神经细胞体外培养时形态无明显差异,但抗性品系幼虫运动神经元内线粒体明显增多,且神经围鞘与神经节膜厚度之比明显增加。

The clinical symptoms of tiger spot fish poisoning includes gastrointestinal,cardiovascular and neurological symptoms.The tiger spot fish poisoning can lead to persistent paresthesia with characteristic temperature perversion.Peripheral nerves damage is more severe in farther limbs.

"老虎斑"鱼中毒临床表现在消化、心血管、神经三系统,可造成持续长时间的神经感觉异常,并以温度感觉倒错最具特征性,其周围神经损害主要在肢体远端,且下肢重于上肢,而无颅神经损害体征。

Trigeminal nerve abnormality did not occur. Conclusion The clinical symptoms of tiger spot fish poisoning includes gastrointestinal,cardiovascular and neurological symptoms.The tiger spot fish poisoning can lead to persistent paresthesia with characteristic temperature perversion.Peripheral nerves damage is more severe in farther limbs.

"老虎斑"鱼中毒临床表现在消化、心血管、神经三大系统,可造成持续长时间的神经感觉异常,并以温度感觉倒错最具特征性,其周围神经损害主要在肢体远端,且下肢重于上肢,而无颅神经损害体征。

Focusing on some disadvantages in standard BP algorithm, such as low convergence rate, easily falling into local minimum point and weak global search capability, Genetic algorithm is used to optimal the connection weight of BP Algorithm in this paper, and construct a GA-BP algorithm of evolutionary neural network, and the algorithm is applied to the control of BLDCM speed adjusting system.

针对标准BP算法存在全局搜索能力弱和易陷入局部极小点等缺点,本文将遗传算法与BP神经网络相结合,构造了一种新的进化神经网络GA-BP算法,并将该算法应用于无刷直流电机调速系统的控制,仿真结果表明,与传统的PI控制系统相比,该算法得出的电机控制曲线几乎无超调,与基于BP算法的速度控制系统相比较,具有收敛速度快、不易陷入局部极小的优点。

Results: Neuroepithelial stem cells derived from the embryonic neural tube could expand into neurospheres in the free serum medium and express nestin.

结果: GFP转基因鼠神经管来源的神经上皮干细胞在无血清培养基内能增殖形成神经球,呈巢蛋白阳性。

According to cranial nerve palsies without cranial nerve invasion of the imaging features,The occurrence rate of cranial nerves involvement was 1.16 percent.

根据颅神经麻痹而无颅神经浸润的影像征象诊断颅神经周围浸润发生率为1.16%。

When aborted rats were injected with 10 IU/g IFN-γin group D, compared with group A, expression of TNF-αinmmuopositive substance in the nucleus pre-opticus medialis, nucleus supra-opticus, nucleus pre-opticus mango celluaris, nucleus periventricularis hypothalami, nucleus paraventricularis hypothalami, nucleus arcuatus hypothalami were highly increased, conversely, the ones in the nucleus pre-opticus suprachiasmaticus, neurohypophsis, adenohypophysis, ovary were obviously decreased, the change in the uterus was not remarkable; Compared with group B, expression of TNF-αin the arcuatus hypothalami was obviously enhanced, while in the nucleus pre-opticus suprachiasmaticus, nucleus pre-opticus mango celluaris, nucleus periventricularis hypothalami, nucleus paraventricularis hypothalami, nucleus ventromedialis hypothalami, nucleus dorsomedialis hypothalami, neurohypophsis, pars intermedia, ovary, the results were on the contrary, the uterus had no significantly variation; Compared with group C, expression of TNF-αin the nucleus pre-opticus medialis, nucleus supra-opticus, nucleus paraventricularis hypothalami, nucleus arcuatus hypothalami, adenohypophysis and pars intermedia had an obviously risen trend, however, the variation in the nucleus pre-opticus suprachiasmaticus, nucleus periventricularis hypothalami, neurohypophsis, pars intermedia, follicle and corpus luteum was completely opposite, uterus had no obviously change.

外源腹腔注射10 IU/g IFN-γ后,同A组相比:D组TNF-α免疫阳性产物在下丘脑视前内侧核、视上核、视前大细胞核、室周核、室旁核、弓状核显著增高,在视交叉上核显著降低,在其它核团较A组无显著差异,在神经垂体、垂体前叶、卵巢中阳性产物表达均较A组显著降低,在子宫中的表达较A组变化不明显;同B组相比:D组TNF-α免疫阳性产物在弓状核显著增高,在视交叉上核、视前大细胞核、室周核、室旁核、腹内侧核、背内侧核、神经垂体、垂体中间部、卵巢各部阳性物质表达均显著降低,在子宫表达变化不显著;同C组相比:D组下丘脑视前内侧核、视上核、室旁核、弓状核、垂体前叶与中间部均显著增高,在视交叉上核、室周核、神经垂体、卵泡、黄体中均显著降低,子宫中表达变化不明显。

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