无神经的

Accordingto the difference of HA gene,which is separated 15 stype from H1 to H15;according to difference ofNA gene,which is separated 9 stype from N1 to N9.It is no cross-reaction between different HA orNA,so it is diffcult to detective.

根据流感病毒的血凝素和神经氨酸酶的抗原性差异，可将A型流感病毒分为不同的亚型，A型禽流感病毒的HA已发现16种，NA有9种，不同的H抗原或N抗原之间无交叉反应，给该病的防制带来了极大的困难。

Recently, many foreign researchers found that the tetrodotoxin-resistant voltage-gated sodium channel, Nav1.8, which is expressed only by unmyelinated small-diameter sensory neurons associated with nociception in dorsal root ganglion and trigeminal ganglion, is involved in pain pathways and play a key role. Thus it provides a new idea in pain research.

近年来，国外众多学者发现河豚毒素(tetrodotoxin，TTX)不敏感型(TTX-resistant，TTX-R)电压门控钠通道Na_v1.8与疼痛的关系极为密切，其仅分布在背根神经节(dorsal root ganglion，DRG)和三叉神经节(trigeminal ganglion，TG)中的与伤害性感受密切相关的无髓鞘的小直径感觉神经元胞体上，它为疼痛的研究提供了新的思路。

"Apraclonidine, a selective alpha-2-agonist, was developed to lower intraocular pressure and minimize the systemic side effects associated with the use of its parent drug, clonidine," write Patrick Watts, MBBS, MS, from the University Hospital of Wales in Cardiff, United Kingdom, and colleagues."An investigation of the site of action of apraclonidine incidentally uncovered a reversal of anisocoria in patients with absent sympathetic innervation of one pupil due to its alpha-1-effect on a pupil with denervation supersensitivity.... The easy availability of apraclonidine, its mild alpha-1-agonist activity, and its hitherto benign safety profile has encouraged its use as a first-line drug in the diagnosis of oculosympathetic paralysis."

英国加地夫市威尔斯大学附设医院的外科学硕士Patrick Watts及研究同仁指出，Apraclonidine是一种选择性的α-2-拮抗剂，是用来降低眼内压，并减少其母系药物降保适使用上的相关全身性副作用；在一项针对apraclonidine作用位置的研究中，因其单侧瞳孔神经切除之α-1-效应，而附带提出单侧瞳孔无交感神经支配患者之瞳孔大小不等为可逆转，apraclonidine之高可利用率，其轻微的α-1-拮抗活性，以及迄今良好的用药安全档案，更强化其作为视交感神经瘫痪诊断第一线药物的使用率。

Of 28 diabetic patients with chronic Wagner grades I-III foot ulcers without clinical symptoms of arteriopathy, 87% had type 2 diabetes. Average age was 60.2 9.7 years, and average diabetes duration was 18.2 6.6 years. All patients had signs of neuropathy, and their ulcers had failed to improve during three months of full standard treatment. Subjects were randomized to receive HBO, twice daily, five days weekly for two weeks, or to a control group.

慢性Wagner等级I-III足部溃疡而无动脉病变之临床症状的28名患者中，有87%患有第二型糖尿病，这些患者的平均年龄为60.2 ±9.7 岁，平均罹患糖尿病的时间为18.2 ±6.6年，所有患者都有神经病变的徵兆，而且他们再经过三个月的标准治疗后，溃疡的情形仍未获改善，受试者经由随机化接受HBO治疗，每天两次、每周五天，共持续二个星期。

Results The negative correlations were found on the Glasgow Outcome Scoreto the items such as conscious state at admission,Glasgow Coma Score,psychiatric symptoms,hemiplegia,Babinski sign,abnomal degree of Electroencephalogram,focal lesions found by neuro-image investigation and mean peak flow velocityand pulsatility indexof basilar artery and vertebral arteries by transcranial Doppler ultrasonography investigation;The non-correlation was found on the Glasgow Outcome Score to theitems such as headache,febrile,epilepˉsia style,the involvement of cranial nerve,dystaxia,neck stiffness,Cerebrospinal fluid investigation and blood serum enzymology.

结果 入院时的意识状态、GCS、精神症状、偏瘫和/或偏身感觉障碍、巴彬斯基征以及脑电图异常程度、影像学所见的病灶范围、基底动脉和椎动脉的平均峰流速、脉动指数和Glasgow预后评分呈负相关；头痛、发热、癫痫类型、颅神经受累情况、共济运动、脑膜刺激征、脑脊液检查（含压力、蛋白定量、细胞数、HSV-PCR）以及血清酶学的变化和Glasgow预后评分之间无相关性。结论入院时的意识状态、GCS、精神症状、局灶性神经系统体征以及脑电图异常程度、影像学所见的病灶范围、后循环的血管痉挛程度和血流阻力等是影响病脑预后的主要因素。

Results The negative correlations were found on the Glasgow Outcome Scoreto the items such as conscious state at admission,Glasgow Coma Score,psychiatric symptoms,hemiplegia,Babinski sign,abnomal degree of Electroencephalogram,focal lesions found by neuro-image investigation and mean peak flow velocityand pulsatility indexof basilar artery and vertebral arteries by transcranial Doppler ultrasonography investigation;The non-correlation was found on the Glasgow Outcome Score to theitems such as headache,febrile,epilepˉsia style,the involvement of cranial nerve,dystaxia,neck stiffness,Cerebrospinal fluid investigation and blood serum enzymology.

结果 入院时的意识状态、GCS、精神症状、偏瘫和/或偏身感觉障碍、巴彬斯基征以及脑电图异常程度、影像学所见的病灶范围、基底动脉和椎动脉的平均峰流速、脉动指数与Glasgow预后评分呈负相关；头痛、发热、癫痫类型、颅神经受累情况、共济运动、脑膜刺激征、脑脊液检查（含压力、蛋白定量、细胞数、HSV-PCR）以及血清酶学的变化与Glasgow预后评分之间无相关性。结论入院时的意识状态、GCS、精神症状、局灶性神经系统体征以及脑电图异常程度、影像学所见的病灶范围、后循环的血管痉挛程度和血流阻力等是影响病脑预后的主要因素。

Antecedent trial, SAINT I, and the critical commentary stimulated by it, which called attention to its interpretively challenging primary outcome measure—a shift in the full-scale modified Rankin scale score—and to other statistical shortcomings;(2) the cogency of the STAIR recommendations, to which the development of NXY-059 closely adhered; and (3) the inherent physiochemical shortcomings of NXY-059 as a neuroprotective agent—its polar, nonlipophilic nature, poor blood– brain barrier penetrability, nonphysiological oxidation potential, and low potency.

应注意SAINT I期试验有争议的结局指标以及统计方法的缺陷；（2）NXY-059试验严格遵守STAIR推荐；（3）NXY-059作为神经保护剂固有的生理生化性质的缺陷：该药的极性、非脂溶性、较差的血脑屏障穿透性、无生理性的氧化能力以及低效价。

We found that 1 mutant EG4 cells showed typical characteristics of pluripotent stem cells which had no obvious difference with wild cells; 2 When induced by 10〓 M retinoic acid , mutant EG4 cells differentiated into adipocytes with high frequency compared with mutant cells, suggested that EGFR plays a role in adipocyte differentiation; 3 when injected into nude mice, mutant teratocarcinomas contained a large amount of connective tissues as well as skeletal muscle, while wild EG4 cells produced frequently cartilage, keratinocyte and neuroepithelium.

我们建立了稳定表达胞内区功能缺失的外源EGFR cDNA片段的EG4细胞，分析其生长分化特性，发现 1）突变型细胞可在未分化状态下维持长时间的增殖，表明EGFR对EG多能干细胞表型无明显影响；2）〓 M的维甲酸A(retinoid acid A，RA)诱导后，大部分对照组细胞分化为脂肪细胞，而突变型细胞分化为脂肪细胞的比例明显较少，表明EGFR在脂肪细胞的发育分化中具有一定的调节作用；3）畸胎瘤切片分析显示，突变型瘤组织分布有大量的未分化细胞和结缔组织，分化细胞以肌肉细胞为主；对照组瘤组织含丰富的角质上皮、软骨、神经管等依赖EGFR的分化组织。

DRG co-cultured with sciatic nerve undergoing Wallerian degeneration for 14 days in vivo in serum free DMEM/F12,1 sciatic nerve segment was added into co-culture system at the first moment, the axons were strong and straight and could adhered to each other, and the number of axons dramatically reduced compared with that of DRG cultured alone in serum free medium.

分别在无血清和有血清的条件下将新生鼠的背根神经节和体内变性14天的大鼠坐骨神经段进行联合培养作为实验组，并以在相应条件下单独培养的DRG的轴突的生长情况作为对照组来观察比较轴突的生长情况。

2DRG co-cultured with sciatic nerve undergoing Wallerian degeneration for 14days in vivo in serum free DMEM/F12,1sciatic nerve segment was added into co-culture system at the first moment,the axons were strong and straight and could adhered to each other,and the number of axons dramatically reduced compared with that of DRG cultured alone in serum free medium.2DRG cultured in serum free DMEM/F12for 4days,then the sciatic nerve segment was added into the culture system for 3days,the axons became straight and part of them adhered to each other.

分别在无血清和有血清的条件下将新生鼠的背根神经节和体内变性14天的大鼠坐骨神经段进行联合培养作为实验组，并以在相应条件下单独培养的DRG的轴突的生长情况作为对照组来观察比较轴突的生长情况。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失