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In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis. CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

The sharp difference suggests that they have different origins: the former comes from allochthonous sapropel-type organisms of the lower strata and is the remains of crude oil, and the latter is autochthonous humic-type organic matter of sedimentary rocks between the basalt layers.

玄武岩中铜矿石沥青的δ13CV-PDB为-27.3‰～-33.2‰，平均-31.97‰，沉积岩中铜矿石碳质的δ13Cv-PDB为-20.2‰～-23.2‰，平均-22.11‰，表明二者无明显成因联系，前者属腐泥型，为石油的遗迹，来自下部地层；后者为腐植型，来自原地沉积的陆生高等植物。

Biological characteristics of Curvularia lunataBoedijn had been preliminarily studied. Optimal mediums for pathogen growth were PSA,PDA and OMA.For mycelia growth,sporulation and conidial germination of pathogen,optimal temperature was 25～30℃,and pH 5～9.Among the tested carbon and nitrogen resources,sucrose,glucose,carbamide,sodium nitrate,etc were beneficial for mycelia growth and sporulation.The conidia germination is strict in RH requirement:Conidia can germinate at RH 81%～98%,or have 100% germin...

香蕉大灰斑病菌适合生长的培养基有PSA、PDA和OMA；菌落生长、产孢和孢子萌发最适宜的温度为25～30℃，pH 5～9；在碳源和氮源中，蔗糖、葡萄糖、尿素、磷酸氢二氨和硝酸钠有利于病菌生长和产孢；分生孢子萌发对湿度有严格的要求，RH≥80%以上分生孢子萌发，随湿度增加萌发率增高；光照对菌丝体无显著影响，光暗交替有利于孢子的形成；孢子致死温度为55℃(10min)。

Five synthesis methods of AlN powder were discussed, namely direct nitrogenation of Al powder, carbothermal reduction of Al2O3, chemical vapor deposition, sol-gel method, self-propagating high-temperature synthesis and plasma chemical synthesis. The choice of AlN sintering additives and five sintering technologies were analysed, namely hot pressing sintering, pressureless sintering, spark plasma sintering, microwave sintering and self-propagating sintering. The preparation processes of AlN substrate and its influencing factors were expounded.

介绍AlN陶瓷的典型性能和导热机理；讨论AlN粉末的5种合成方法：铝粉直接氮化法、Al2O3碳热还原法、化学气相沉积法、溶胶凝胶法、自蔓延高温合成法和等离子化学合成法；分析AlN烧结助剂的选择和5种烧结工艺：热压烧结、无压烧结、放电等离子烧结、微波烧结及自蔓延烧结；阐述AlN基板的制备工艺及其影响因素。

Oncidium on 15 hrs light period and night break treatments exhibited heavier fresh and dry weights, lower total soluble sugar content in pseudobulb because nutrient translocated for inflorescence development, however water content was no significantly different. After treatment of 9 hrs and 12 hrs light period, the total soluble sugar content in pseudobulb of Oncidium was higher than other treatments because of consuming less nutrient transfered from pseudobulb due to poor inflorescence development and the quality of inflorescence also showed worse.

以15小时电照周期处理与暗期中断处理之植株乾鲜重较重，含水量则无明显差异，而假球茎内的全可溶性糖含量则较其他处理组低，因为花序发育时，假球茎内的碳水化合物转移到花序，以提供花序发育所需之养分。9小时电照周期处理组与12小时电照周期处理组方面，因为其花序品质较差，消耗的养分较少，故其假球茎内的全可溶性糖含量较高。

Its subject coverage includes: removal of phosphorus from carbon and alloy (including high alloy and stainless) steel baths in the converter; fluxes, flux action; blowing; slag formation and dynamics; slag/melt interaction; slagless refining; continuous processes; treatment of secondary metal melts; effect of treatment methods on final product quality and pr

它的主题涉及的范围包括：转炉中从碳和合金钢液池除磷；助熔剂，助熔作用；吹炼；炉渣形态和动力学；矿渣/溶解交互作用；无渣精炼；连续过程；再生金属融解处理；最终产品质量和性能处理方法的作用；钢特性中磷水平的作用。

The progress on the extraction of uranium from phosphate rock, lignite, carbonacious shale, uraniferous metallic complex ores and seawater is also described briefly. The progress on the disposal and treatment of effluent and tailings from uranium mill and technical flowsheet without producing wastes is also introduced concisely.

还描述了由磷炔岩、褐煤、碳质页岩、含铀多金属矿及海水提铀的重大新进展，扼要阐述铀水冶的废水及尾矿处理和铀水冶的无废物工艺流程研究的新进展。

Methods Cells were maintained in DMEM medium with 10% fetal bovine serum. Five days before the beginning of experiments, the cells were seeded in phenol red-free DMEM medium containing 5% charcoal dextran-treated FBS. The cells were harvested, and seeded in 6-well culture plates or in 75ml flacks. After NP, BisA and DBP treatments for 72h, the cells were harvested, and mRNA and protein expression of PCNA, bcl-2 and bax were detected by reverse transcription-polymerase chain reaction and immunohistochemistry, respectively.

方法］T47D细胞在含10%胎牛血清的DMEM培养液中进行常规传代培养，实验前将细胞转移至无酚红DMEM（含5%活性碳葡聚糖苷处理过的FBS）中继续培养5d，收集细胞，PBS洗涤后接种於内置盖玻片的6孔板或75ml培养瓶中，用32×10^(-7)mol/L NP、32×10^(-7)mol/L BisA及32×10^(-6)mol/L DBP对细胞分别处理72h，用半定量RT-PCR技术观察这3种化合物对核增殖抗原PCNA、bcl-2及bax mRNA表达的影响，并用免疫组化方法对结果进行验证。

In this paper, a total of 56 relatively nonpoint source pollution sediment samples were collected from the tidal flats of the Jiuduansha shoal and the Chongming island of the Yangtze river estuary. The main properties i. e., grain size distribution, contents of DCB (dithionite citrate bicarbonate extracted iron Fe(subscript d, AAO extracted iron Fe(subscript o, total Fe, DCB extracted Mn Mn(subscript d, total Mn, organic matter, magnetic susceptibility of the samples, as well as the concentrations of Cu, Zn, Pb, Cr, Cd and Ni in the samples, were determined. Basing on the data, the relation of the sediment properties to heavy metal concentrations was evaluated with pearson's rank and partial rank correlation analysis.

采集长江口无明显点源污染的崇明东滩和九段沙潮滩56个沉积物样品，测定沉积物原样和粘粒中Cu，Zn，Pb，Cr，Cd和Ni的含量以及沉积物的主要性状（粒径分布、游离铁、活性铁、总铁、游离锰、总锰、有机碳和磁化率等），以相关分析和偏相关分析研究沉积物中重金属含量与沉积物主要性质之间的关系。

Results showed that with increasing carbon,phosphorus, sulphide,manganese content in steel the core loss of cold rolled non-oriented electrical...

结果表明，随钢中碳、磷、硫、锰含量的增加，冷轧无取向电工钢铁损明显增加；随硅含量增加，钢的铁损降低；铝与钢中的氮形成细小的AlN颗粒，阻碍钢材晶粒长大，随钢中铝含量增加，铁损增加。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。