无汗

She developed enlargement and soreness of her right parotid gland, but no fever , adenopathy, weight

她出现右侧腮腺肿大和疼痛，但无发热、病、重下降和盗汗。

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis. CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗(来源：A44B8787C论文网www.abclunwen.com)功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

The fungus thrives well in moist and dark environments, so to keep your feet from sweating too much, apply unscented antiperspirant on it, especially if you wear closed-shoes for most of the day.

真菌兴，以及在潮湿和黑暗环境中，所以保持你的脚从出汗太多，又适用于无气味antiperspirant它，尤其是当你戴上封闭式鞋一天的大部分时间。

The main clinical syndrome of kidney deficiency with blood stasis type are easy to wake,forgettery,waist and knee ache,operation wound numbness, suffering upper limb numbness,excessive dream,fatigue,agitated and easy anger,hectic fever,undersexed,dry mouth,insomnia,wine catamenia color, dismal tongue,venation under the tongue is wine,tongue moss are infertile, a thin pulse.

脾肾两虚型主要表现为面色萎黄、腰膝酸痛、潮热、体倦乏力、健忘、自汗、烦躁易怒、患侧上肢麻木、舌质淡、舌苔薄、脉弦、脉细；有病无证型为乳腺癌术后，无明显不适，舌质淡、舌苔薄、脉弦或细；肾虚血瘀型主要主要表现为腰膝酸痛、健忘、易醒、术口麻木、患侧上肢麻木、经色暗红、多梦、体倦乏力、烦躁易怒、潮热、性欲减退、口干、失眠、舌质暗、舌下脉络青紫、舌苔薄、脉细。

The intraperitonealLD_(50) values in mice of VES and VDPG were 0.16mg/kg and 0.39mg/kg,respectively. The intraperitoneal LD_(50) value in cockroach of VDPG andVES were 2.32μg/g and 1.87μg/g, respectively. After intraperitonealinjection of the venom in mice, the main poisoning symptoms includedlethargy, ataxia, diaphoresis, convulsion, anorexia, shortness of breath,and difficulty to open eyes, etc. Whereas the mice injected withphysiological saline acted normally.

两种粗毒都对小鼠和蜚蠊有较强的毒性，其中毒囊粗毒和电刺激粗毒对小鼠的LD_(50)值分别为0.39mg／kg和0.16mg／kg；毒囊粗毒和电刺激粗毒对蜚蠊的LD_(50)值分别为2.32μg／g和1.87μg／g体重；小鼠经腹腔注射粗毒后，出现无生气、共济失调、排汗、痉挛、食欲减退、呼吸短促、睁眼困难等症状，而注射生理盐水的小鼠活动正常。

Result: Coughs in 48 cases(85.7%),chest pain in 5 cases (8.9%), does not have respiratory tract symptom and so on the cough, expectorate in 8 cases (14.3%), low heat in 19 cases (33.9%), appetite is bad in 15 cases (26.8%), robs the perspiration in 12 cases (21.4%), becomes emaciated in 6 cases (10.7%), feels weak in 9 cases (16.1%).

结果：咳嗽48例（占85.7%），胸痛5例（占8.9%），无咳嗽、咳痰等呼吸道症状者8例（占16.7%），低热19例（占33.9%），纳差15例（占26.8%），盗汗12例（占21.4%），消瘦6例（占10.7%），乏力9例（占16.1%）。

There was no significant difference in the average dosage between patients with and without hypohidrosis in each age group. However, there was a significant difference in the average age between patients with and without hypohidrosis in each dosage group.

在控制年龄因素的影响后，托吡酯剂量对泌汗障碍的发生无显著影响；而在控制剂量因素的影响后，年龄仍显著影响泌汗障碍的发生。

There was no significant difference in the average dosage between patients with and without hypohidrosis in each age group. However, there was a significant difference in the average age between patients with and without hypohidrosis in each dosage group.Both developing and mature mice were treated with a low (20 mg/kg/day) and high dose (80 mg/kg/day) of topiramate for four weeks. Each group contained 12 mice.

在控制年龄因素的影响(来源：Abe0e0eBC论文网www.abclunwen.com)后，托吡酯剂量对泌汗障碍的发生无显著影响；而在控制剂量因素的影响后，年龄仍显著影响泌汗障碍的发生。2周龄和2月龄小鼠随机分配至托吡酯低剂量组(20 mg/kg/d)、高剂量组(80 mg/kg/d)和对照组，每组12只。

Horner's syndrome, apical cancer cervical sympathetic ganglion of oppression or violation occurs when the eye ipsilateral depression, ptosis, miosis, eye fissure narrow, ipsilateral upper chest skin temperature, sweat-free and so on.

Horner's综合征肺尖癌压迫或侵犯颈交感神经节时，出现患侧眼球凹陷，上睑下垂、瞳孔缩小、眼裂狭窄、患侧上半胸部皮肤温度升高、无汗等。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。