无效地

RESULTS:(1) ET-1 could increase total protein production, surface area, ERKs activity and ［Ca2+］i in cultured cardiomyocyte in dose-dependent manner at concentrations ranging from 10-9 to 10-7 mol/L. And this effect could be abolished by BQ123, an antagonist of ETA receptor, partly inhibited by PTX, but not by BQ788, an antagonist of ETB receptor.（2）The activation of ERKs and the increase of ［Ca2+］i induced by ET-1 were obviously inhibited by PD98059, a selective ERKs kinase inhibitor, and nifedipine, a calcium channel blocker, respectively. Both antagonists partially inhibited ET-1-stimulated cardiomyocyte hypertrophic response.(3) Staurosporine, a selective PKC inhibitor, could inhibit ET-1-stimulated cardiomyocyte hypertrophic response and increase of ［Ca2+］i, but not affect the activation of ERKs.

结果： ①ET-1浓度依赖性增加新生大鼠心肌细胞蛋白质含量和心肌细胞表面积、ERKs活性及［Ca2+］i浓度，以上作用可被ETA受体拮抗剂BQ123所完全抑制，被百日咳毒素部分抑制，而ETB受体拮抗剂BQ788则无效；②ERKs激酶特异性抑制剂PD98059可完全抑制ET-1激活ERKs的作用，钙通道拮抗剂硝苯地平可明显抑制ET-1介导的［Ca2+］i浓度增加，但二者皆仅部分抑制ET-1介导的心肌细胞肥大反应；③蛋白激酶C选择性抑制剂staurosporine并不能明显抑制ET-1介导的ERKs激活，但可抑制ET-1介导的的［Ca2+］i浓度增加及心肌细胞肥大反应。

Finally, in the matter of marriage, the council restricted the force of the law which forbade marriage between in-laws related through sinful sex relations,[8] between those related through a brother or sister's solemn espousals, or by the spiritual relationship set up through the sacrament of baptism--the council frankly admitted that the number of these prohibitions had become an occasion of sin to very many, of invalid marriages, for example, contracted in ignorance, which the partners refused to abandon, and which could not be broken off without danger of further sin.

最后，在这个问题上的婚姻，安理会限制了部队的支持下，法律禁止结婚的法律有关通过罪孽深重性别关系， [ 8 ]有关之间通过一个兄弟或姐妹的严正espousals ，或精神关系的成立，通过圣洗圣事中-安理会坦率地承认，一些这些禁令已成为罪恶之际非常多，无效婚姻的，例如，合同中的无知，这是合作夥伴拒绝放弃，并不能中断的危险进一步罪孽。

"I think it's the height of irresponsibility and I really resent it - this was his decision to go to war, he went with an ill-conceived plan, an incompetently executed strategy, and we should expect him to extricate our country from this before he leaves office," the senator said this morning.

&我认为这是一种极端不负责任的做法，我真真切切地痛恨它。--发动战争是他的决定，他依靠错误的构思，无效的战略把大家卷入战争。我们希望在他离任之前把我们的国家从中解救出来。&今天早晨，克林顿参议员这样说。

The effectiveness of the letter of guarantee, its wordings and its enforceability will determine whether the carrier shall bear the legal responsibility. Inthis part of the article, I also discuss different types of letter of guarantee, as well as their different validity in law, i.e. The bona fide one is valid between the two parties of it, while the mala fide one is void even between the two parties of it.

本节着重介绍了保函在各种不同情况下的的法律性质，以及不同保函的不同法律效力，即善意保函在其双方当事人之间有效，恶意保函即使在其双方当事人之间也无效，使我们在实践中合理地利用保函来达到我们的目的。

You can NOT install X-Plane from disk, than update it and than expect to install any part of scenery as this will not work.

你不能去更新以后再安装其他没有安装的地景，这是无效的。

Preclinical and early-stage clinical testing, and prioritisation of products for later-stage testing should be improved to maximise use of research resources, and reduce further testing of unsafe or ineffective products.

应该改善临床前研究和早期临床测试及优化适用於晚期测试的产品，从而最大化地利用研究资源，减少对不安全或者无效产品的进一步测试。

Preclinical and early-stage clinical testing, and prioritisation of products for later-stage testing should be improved to maximise use of research resources, and reduce further testing of unsafe or ineffective products.

应该改善临床前研究和早期临床测试及优化适用于晚期测试的产品，从而最大化地利用研究资源，减少对不安全或者无效产品的进一步测试。

Preclinical and early-stage clinical testing 艳照门, and prioritisation of products for later-stage testing should be improved to maximise use of research resources, and reduce further testing of unsafe or ineffective products.

应该改善临床前研究和早期临床测试及优化适用于晚期测试的产品，从而最大化地利用研究资源，减少对 xiao76论坛不安全或者无效产品的进一步测试。

Preclinical and early-stage clinical testing, and prioritisation of products for later-stage testing should be improved to maximise use of research resources, and reduce further testing of unsafe 青涩五月天 or ineffective products.

应该改善临床前研究和早期临床测试及优化适用于晚期测试的产品，从而最大化地利用研究资源，减少对亚洲色图不安全或者无效产品的进一步测试。

Preclinical and early-stage clinical testing, and prioritisation of prod ucts for later-stage testing should be improved to maximise use of research resources, and reduce further testing of unsafe or ineffective products.

应该改善临床前研究和早期临床测试及优化适用于晚期测试的产品，从而最大化地利用研究资源，减少对不安全或者无效产品的进一步测试。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。