无抑制

The molecular weight of dextransucrase measured by SDS-PAGE was 170 kDa ,which was similar to the enzyme from Leuconostoc mesenteroides. The enzyme had an optimum temperature between 25and 30℃ and an optimum pH of 5.4. It was relatively stable in the range of pH 5.0 to 7.0, but the stability declined rapidly as soon as the temperature rose over 35℃.

以蔗糖为底物，酶促反应的最适温度为25～30℃，最适pH值为5.4，动力学常数Km值为10.43 mmol/L；酶活在pH 5.0～8.0较为稳定，在室温（25℃）保藏4 天仍有59%的酶活力，4℃保存7周酶活力仅下降一半，但在35℃以上失活很快；Ca2+对催化作用有较大的促进，Mg2+有微弱的促进作用，K+对催化反应无影响，Cu2+的抑制作用最强。

Neu- roleptics such as Haloperidol and Tiapide might increase theta waves of the anterior and medius areas of the head of brain electrical back- ground activity of children with TS, and affect their memory func- tion, but not affect their intelligence, personality and behavior.

氟哌啶醇和泰必利等精神抑制药物可能使TS患儿头前中部区域的脑电背景活动θ波增多；并对TS患儿的记忆功能可能产生一定的影响，但对TS患儿的智力、个性和行为无明显影响。

We show that the Wnt signaling actiator 6-bromoindirubin-3'-monoxime releases MSCs from the osteoinhibitory effects of Dickkopf-1, whereas LiCl treatment does not.

我们也发现Wnt信号激活剂BIO会解除DDK1对MSC的成骨抑制作用，而LiCl处理则无这种作用。

All patients were treated by anticholinesterase,some patients were also treated by corticosteroid therapy,immunosuppressant or both.After24months follow up,all cases were relieved,and no myasthenic crisis occured.

全部病例用胆碱酯酶抑制剂治疗，部分加用肾上腺糖皮质激素或免疫抑制剂，病情均得到缓解，随诊至今无危象发生。

The results indicated that the proliferation of K562 cells was not inhibited by the cytotoxicity of doxorubicin in combination of naringenin with doxorubicin.

结果表明：两药联合实验组（Post1小时组、Post24小时组）中，柚皮素无明显降低阿霉素对K562细胞的增殖抑制作用。

Ditong nasitis drop had no remarkable effect on injuring the function of frog mucosa cilia.

滴通鼻炎水在整体实验和离体实验中对蛙黏膜纤毛的功能无明显影响，但滴通鼻炎水浸润30 min后对黏膜纤毛运动有抑制作用。

Glioma is still one of refractory disease in the neurosurgical field; the development of new primary and adjuvant treatment is vital. Recently, the gene therapy of glioma is developed rapidly and there are many methods about the gene therapy that include: suicide gene therapy, immunologic gene therapy, drug resistangce gene therapy, angiostatin gene therapy and so on. The sucide gene therapy is the most potential approach of antitumer, these nonmammalian genes encode enzyme that convert nontoxic prodrugs into highly toxic metablites. Cells transfected with suicide genes are targeted for specific negative selection, witch can be induced by administrtion of the corresponding produg. Among the enzyme/produg combinations, two of the best characterized system are herpes simplex virus thymidine kinase /ganciclovir and Escherichia coli cytosine deaminase /5-flourocytosine (5-FC). The formor can convert the antiviral nucleoside analogs acyclovir , ganciclovir to their nucleoside monophosphate derivatives, the monophosphate forms are subsequently phosphorylated by endogenus cellular kinases to triphosphates, these molecules are potent inhibitors of DNA synthesis.

近年来脑胶质瘤的基因治疗发展迅速，应运而生的方法有自杀基因、免疫基因、多药耐药基因以及抗血管生成基因等，其中自杀基因被认为是最有前景的基因治疗方法，它又称病毒介导的酶／药物前体疗法，是利用转基因技术将哺乳动物细胞中所不含有的自杀基因转入到哺乳动物肿瘤细胞中，该基因表达的产物可将无毒的药物前体转化为毒性药物，从而选择性杀伤该肿瘤细胞，常用的自杀基因有单纯疱疹病毒-胸苷激酶基因和大肠杆菌胞嘧啶脱氨酶基因，前者催化无毒性抗病毒核苷类似物如丙氧鸟苷、无环鸟苷等成为单磷酸核苷衍生物，然后在内源性细胞激酶作用下转化为具有明显毒性的三磷酸核苷，作为DNA合成链的终止剂和DNA合成酶的抑制剂，干扰细胞DNA的合成；后者编码的胞嘧啶脱氨酶可催化5-氟胞嘧啶（5-FC）脱氨成为5-氟尿嘧啶（5-FU），然后代谢为有毒性的5-氟尿嘧啶-5′三磷酸（5-FUTP）和5-氟-2′脱氧尿嘧啶-5′磷酸（5-FdUTP），5-FUTP通过与UTP竞争性结合而抑制mRNA和tRNA的合成，5-FdUTP则作用于胸苷合成酶，导致TMP衰竭而阻止DNA的合成，最终诱导肿瘤细胞凋亡。

Imaging research in nude mice bearing human breast cancer exhibited that radioactivity has been accumulated in tumor site, While only slightly visualized or nonvisualized in the control group of mice.(4) Compared with the negative control group, the 〓I-EGF trial groups remarkably suppressed the growth of tumor.

〓I-EGF静脉和瘤内注射对荷瘤裸鼠有较强的肿瘤抑制作用，病理组织检查及透射电镜细胞超微结构观察发现肿瘤细胞发生一系列不可逆损害变化，而〓I或〓I-白蛋白无此作用； 6。

Nosema disease is a kind of zoonoses, of all ages can be affected by pollution, for human carinii infection and host immune function of severely inhibited closely related to people before that Nosema without sexual reproduction period .

微孢子虫病是一种人兽共患病，各年龄组均可受染，人类为孢子虫感染与宿主的免疫功能严重地受到抑制有密切关系，以前人们认为微孢子虫无有性生殖期。

All patients in our group were stable during perioperative period without anesthesia complications like respiratory depression, hypotension or oliguria.

所有患者均平稳度过围手术期，无明显呼吸抑制，血流动力学稳定，未出现少尿等并发症。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。