无尿的

After treating with 1% pancreatin,lecithinase C and 10% aether,the allantoic fluid of this virus could agglutinate the erythrocytes of chicken,sheep,human being,mouse and rabbit,while the allantoic fluid of this virus without this treatment had no this agglutinative activity.

经浓度1%胰酶、卵磷脂酶C和10%乙醚处理后，该病毒尿囊液可以凝集鸡、绵羊、人、小鼠和兔的红细胞，而未处理的病毒尿囊液则无此凝集活性。

According to the echocardiography,enlarged internal diameter of left ventricle was found in 8 patients and short-axis fractional shortening of left ventricle 5% in 3 patients.Six out of the above 8 patients presented with shortening of accerlerating time,decreasing of accerlerating time/right ventricular ejective time value and moving forward of spectral peak in different degrees.All patients were given antianginal drugs such as β-recepter blockers,nitrate preparations and part by angiotensin converting enzyme inhibitor,diuretics and digoxin,The illncss of 29 patients were gradually controlled within one week.Three patients with AD were complicated by acute left heart failure.No obvious changes in FS of left ventricle were found on echocardiography by bed.

测量肺动脉瓣口血流频谱，左心室内径增大的8例中有6例出现不同程度的血流加速时间缩短，血流加速时间/右心室射血时间比值减小，频谱峰值前移。31例均给予β受体阻滞剂、硝酸酯类等抗心绞痛治疗，部分给予血管紧张素转换酶抑制剂、利尿剂和地高辛，其中29例在1周内卧位型心绞痛逐步得到控制。3例卧位型心绞痛发作时合并急性左心衰竭者，在床旁观察超声心动图，发现左心室短轴缩短率无显著变化，给予利尿剂、减轻前后负荷等治疗，急性左心衰竭得以纠正。

The comparisons of biochemistry between OP and OR rats The differences between OP and OR rats included not only body weight, but lipids metabolism and insulin sensitivity as well, characterized with insulin resistance, increasing in serum free fatty acids and ketone body, and hepatic TC and TG in OP rats. However, no significant differences were observed in serum TG, TC, LDL, HDL and fasting glucose between OP and OR rats.⑶Comparisons of metabolites in serum, urine and liver tissue between OP and OR rats①There were significant differences in amino acids concentration between OP and OR rats,especially in liver tissue, such as high concentrations in ketogenic and glucogenic amino acids in OP rats, suggesting differences in amino acids metabolism;② The different metabolites between OP and OR rats included increasing of various saturated fatty acids and decreasing of polyunsaturated fatty acids in OP rats;③The urinary metabolites analysis indicated that different structure or metabolism of gut microflora might exist between the two phenotypes, which probably influenced the regulation of body weight gain;④The end-products of catecholamines in urine and intermediates of krebs cycle in serum in OP rats were all up-regulated, suggesting that the activity of sympatheic nervous system and energy metabolism was higher in OP rats than OR rats.

胰岛素耐受实验和胰岛素敏感指数表明OP动物的胰岛素敏感性较OR动物下降，而OP大鼠血清中游离脂肪酸、酮体、肝脏总胆固醇和甘油三酯水平显著升高；但是，OP与OR大鼠血清中总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白和空腹血糖等的水平并无显著性差异；⑶肥胖易感与肥胖抵抗大鼠血清、尿液和肝脏组织提取物中代谢物的比较研究表明：①OP与OR大鼠的血清、尿液和肝组织提取物中多种氨基酸的含量存在显著差异，并以肝组织中的差异氨基酸数量为最多，包括各种生酮和生糖氨基酸水平在OP组的升高，说明氨基酸代谢的差异是两种体重表型大鼠之间存在的重要差异特征之一；②OP与OR动物肝脏和血清差异代谢物中包含多种饱和长链脂肪酸的升高如十四烷酸、十六烷酸、硬脂酸等和多不饱和脂肪酸的下降如亚油酸和花生四烯酸，说明两种体重表型动物的肝脏脂肪酸代谢存在明显差异；③长期高脂饮食喂养后，动物的尿液代谢物分析表明OP与OR动物体内的肠道菌群结构存在差异，这些菌群上的差别可能在动物体重增长的调节上产生影响；④与OR动物相比，OP动物尿液代谢物中儿茶酚胺类递质的代谢终产物如高香草酸、扁桃酸和4-羟基苯乙酸明显升高。

Glioma is still one of refractory disease in the neurosurgical field; the development of new primary and adjuvant treatment is vital. Recently, the gene therapy of glioma is developed rapidly and there are many methods about the gene therapy that include: suicide gene therapy, immunologic gene therapy, drug resistangce gene therapy, angiostatin gene therapy and so on. The sucide gene therapy is the most potential approach of antitumer, these nonmammalian genes encode enzyme that convert nontoxic prodrugs into highly toxic metablites. Cells transfected with suicide genes are targeted for specific negative selection, witch can be induced by administrtion of the corresponding produg. Among the enzyme/produg combinations, two of the best characterized system are herpes simplex virus thymidine kinase /ganciclovir and Escherichia coli cytosine deaminase /5-flourocytosine (5-FC). The formor can convert the antiviral nucleoside analogs acyclovir , ganciclovir to their nucleoside monophosphate derivatives, the monophosphate forms are subsequently phosphorylated by endogenus cellular kinases to triphosphates, these molecules are potent inhibitors of DNA synthesis.

近年来脑胶质瘤的基因治疗发展迅速，应运而生的方法有自杀基因、免疫基因、多药耐药基因以及抗血管生成基因等，其中自杀基因被认为是最有前景的基因治疗方法，它又称病毒介导的酶／药物前体疗法，是利用转基因技术将哺乳动物细胞中所不含有的自杀基因转入到哺乳动物肿瘤细胞中，该基因表达的产物可将无毒的药物前体转化为毒性药物，从而选择性杀伤该肿瘤细胞，常用的自杀基因有单纯疱疹病毒-胸苷激酶基因和大肠杆菌胞嘧啶脱氨酶基因，前者催化无毒性抗病毒核苷类似物如丙氧鸟苷、无环鸟苷等成为单磷酸核苷衍生物，然后在内源性细胞激酶作用下转化为具有明显毒性的三磷酸核苷，作为DNA合成链的终止剂和DNA合成酶的抑制剂，干扰细胞DNA的合成；后者编码的胞嘧啶脱氨酶可催化5-氟胞嘧啶（5-FC）脱氨成为5-氟尿嘧啶（5-FU），然后代谢为有毒性的5-氟尿嘧啶-5′三磷酸（5-FUTP）和5-氟-2′脱氧尿嘧啶-5′磷酸（5-FdUTP），5-FUTP通过与UTP竞争性结合而抑制mRNA和tRNA的合成，5-FdUTP则作用于胸苷合成酶，导致TMP衰竭而阻止DNA的合成，最终诱导肿瘤细胞凋亡。

METHODS: Collaborative meta-analyses were undertaken of 194 unconfounded randomised trials of adjuvant chemotherapy or hormonal therapy that began by 1995. Many trials involved CMF (cyclophosphamide, methotrexate, fluorouracil), anthracycline-based combinations such as FAC (fluorouracil, doxorubicin, cyclophosphamide) or FEC (fluorouracil, epirubicin, cyclophosphamide), tamoxifen, or ovarian suppression: none involved taxanes, trastuzumab, raloxifene, or modern aromatase inhibitors.

对194个开始于1995年的关于辅助化疗或激素治疗的随机试验进行meta分析，许多试验包含了CMF(环磷酰胺、氨甲喋呤、氟尿嘧啶)，蒽环药物为基础的联合化疗比如FAC(氟尿嘧啶、阿霉素、环磷酰胺)或FEC（氟尿嘧啶、表阿霉素、环磷酰胺）及他莫昔芬或卵巢去势；无一包含紫杉烷类、赫赛汀、雷洛昔芬及芳香化酶抑制剂。

In conclusion, our results showed urinous supernatants should be used as candidate to diagnose candidemia by PCR.

综上所述，我们证实在血浆中存在游离DNA，同时发现在尿上清中也存在游离DNA。以前的研究证实尿培养可能对念珠菌血症无诊断意义。

Within natural disposition cortisol treats as the CYP3A4 active with 6 beta -hydroxycortisol in the urine proportion target; Within fresh metabolite 5-MDMT and bufotenine treat as the CYP2D6 active target in the urine proportion the research not to become Yang A mainly because LC/MS/MS to be unable to decide on in the urine 5-MDMT and 6 beta -hydroxycortisol..

以内生性cortisol与6β-hydroxycortisol在尿液中的比例当作CYP3A4活性的指标；以内生代谢物5-MDMT与bufotenine在尿液中的比例当作CYP2D6活性的指标的研究均未成功，主要因LC/MS/MS无法定出尿中5-MDMT及6β-hydroxycortisol。

Abstract］ objective to assess the efficacy and safety of transurethral resection of prostatewith plasmakinetic technique and to improve the qualities of pkrp.methods the data of 273 patients with benign prostatic hyperplasiawere retrospectively studied baseing on the mastering of pkrp.the average maximum urinary flow rate,the average residual urinary volumeand the average international prostate symptom score were analysed.results pkrp was successfully performed on 273 patients.intraoperative blood transfusion was performed in 6 cases,no obturator nerve reflex,transurethral resection syndrome,permanent urinary incontinence occurred and no death cases occurred.the follow-up time was 2～26 months with an average of 5.63 months,postoperative average qmax increased to 15.9 ml/s,and ruv decreased to 16.0 ml/s and the average ipss was 9.compared with those of preoperation,the differences were significant.conclusion pkrp has superior tissue cutting function and hemostasis.it is suggested that transurethral bipolar plasmakinetic resection of prostate be effective and safe.

目的 探讨经尿道双极等离子前列腺切除术的安全性与有效性，提高pkrp质量。方法回顾性分析273例良性前列腺增生患者pkrp资料，比较手术前后最大尿流率、膀胱剩余尿量及国际前列腺症状评分。结果 273例手术均顺利完成，术中输血6例，无闭孔神经反射、永久性尿失禁、经尿道电切综合征及死亡病例，随访2～26个月，平均5.63个月，qmax平均增至15.9 ml/s，ruv平均降至16.0 ml，ipss平均9分。与术前相比，各项指标均有明显改善。结论 pkrp具有良好的组织切割功能及可靠的止血作用，治疗bph安全有效。

BH loading tast and urine pterin analysis can be used as differental diagnosis methods for classical PKU and BH deficiency.

血苯丙氨酸浓度在口服BH后无明显变化，尿喋呤谱分析基本正常的患儿诊断为经典型苯丙酮尿症

In order to detect the concentration of the urine protein β_2-MG,ALb,IgG and THP.

表明2种温度贮存的尿标本，4种蛋白检测结果无显著差异。ALb、IgG和THP的测定值在随意尿和24h尿最有相关性，γ分别为0.7565，0.7845及0.7837。

The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了，排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意，我建议我们在价格上大家各让一半。