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Results Analysis of the expression of proteins of JAK2 in leukemic blasts, there was no detectable constitutive expression of phosphorylated JAK2 in all the AML samples analyzed; Furthermore, we could detect a constitutive activation of STAT 3 by immunoprecipitation of the targeted protein in primary leukemic blasts from 3 of 11 AML patients without any cytokine treatment; Pretreatment clinical characteristics, and treatment regimens did not differ significantly between patients with and without constitutive STAT3 activity, there was not significant relation between the constitutive activation of STAT3 and the FAB subvariety and chromosome karyotype; However, the 3 patients with constitutive STAT3 activity seemed to have adverse treatment outcome, one did not show remission, the other two patients relapsed shortly after remission; Consistent with the above-mentioned result, leukemic blasts from the 3 samples with constitutive expression of STAT3 showed higher percentage of spontaneous apoptosis and S-phase cells.
在实验研究基础上,本研究进一步运用免疫沉淀和Western Blot印迹方法,检测AML患者原代细胞JAK2和STAT3活化情况,并分析了STAT3活化与AML患者预后有关指标改变的关系。结果我们的初步研究发现,11例AML患者中,有3例呈现STAT3组成型活化(STAT3阳性,下同),无一例呈JAK2组成型活化。上述3例STAT3组成型活化与FAB分型和染色体核型改变未见明显相关性;在此3例患者中,1例未取得缓解,另外2例虽然取得短暂缓解,但均在二个月内复发。上述3例STAT3阳性AML患者S期白血病细胞百分率数值较组高,而凋亡率数值较低。
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After groundwork of deep analysis of theory of symmetrical components the digital compensating algorithm used in SVC is reduced.
在深入分析了对称化补偿原理的基础上,推导出用于SVC的数字化无功补偿算式。
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According to this,the best linear unbiased estimate method of location-scale distribution for incomplete interval censored data is presented,the confidence l.
在此基础上,针对位置-尺度分布族提出一种不完全区间数据最佳线性无偏估计方法,得到了其百分位值的置信限估计,并对工程中常见的极值分布、两参数Weibull分布、正态分布进行了详细讨论。
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In this book,i claim that the history based on ratio had produced an unconsciousness abnormality.
这本书,我认为,历史的基础上的比例制作了一个无意识abnormality。
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At first, the theory and method of unconstrained E-pulse synthesis are obtained based on the theoretical deduction.
首先,在理论推导的基础上,给出无约束E-脉冲波形综合的原理和方法。
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He was originally a priest of the Church; along with Narbareck, he created a "burial class", the base of today's Burial Agency, though after betraying the Church to the Mage's Association he was left uncredited.
他原来是一个教会里的神父,和Narbareck一起,他创造了"埋葬等级",埋葬机关的基础,虽然后来背叛了教会和魔术协会他变得无归属。
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It is designed based on the undocumented documents of Microsoft ows.
它的设计基础上,无证文件的Microsoft ows。
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Planted with Phragmites australis and unplanted wetlands were constructed to compare organic matter removal from domestic wastewater based on water budget.
构建了芦苇和无植物人工湿地,在系统水量衡算的基础上比较了两种湿地对生活污水中有机物的去除效果。
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The composition designs and performances of LOVA propellants are investigated on the basis of thorough analysis of constraints of caseless gun bullet system to propellant performance under the program of caseless ammunitions.
论文选择无壳枪弹为应用背景,分析了该系统对发射药性能的约束条件,进行了低易损性发射药的基础配方设计和性能研究。
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These results should provide a foundation for comparison with the results of newer technology and cementless fixation for revision hip arthroplasty.
这些结果为更新的全髋关节翻修手术技术与无骨水泥固定技术的治疗进行比较提供了基础。
- 推荐网络例句
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Finally, according to market conditions and market products this article paper analyzes the trends in the development of camera technology, and designs a color night vision camera.
最后根据市场情况和市面上产品的情况分析了摄像机技术的发展趋势,并设计了一款彩色夜视摄像机。
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Only person height weeds and the fierce looks stone idles were there.
只有半人深的荒草和龇牙咧嘴的神像。
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This dramatic range, steeper than the Himalayas, is the upturned rim of the eastern edge of Tibet, a plateau that has risen to 5 km in response to the slow but un stoppable collision of India with Asia that began about 55 million years ago and which continues unabated today.
这一引人注目的地域范围,比喜马拉雅山更加陡峭,是处于西藏东部边缘的朝上翻的边框地带。响应启始于约5500万年前的、缓慢的但却不可阻挡的印度与亚洲地壳板块碰撞,高原已上升至五千米,这种碰撞持续至今,毫无衰退。