无变化的

Based on varying process of generator terminal parameters after excitation fault, shortages of excitation protective principle of static stability boundary and asynchronous impedance boundary are analyzed. It proposed that excitation fault research relates to large-disturbance stability. Because dynamic power-angle character of generator after excitation fault is non-sinusoidal, there are differences between dynamic power-angle character and static state power-angle character. So it isn't ideal to protective operation result based on small-disturbance stability and static stability boundary criterion. At the same time, it proposed that asynchronous boundary impedance criterion is a constant reactive power circle moving adown j Xd′. It can ensure complete loss-of-excitation generator measuring impedance enter into the circle, but can't ensure the other condition measuring impedance including impossible losing synchronism enter. So loss-of-excitation protection would be maloperation when system voltage drops short and recovers or generator rejects load.③Based on stability principle, it puts forward setting conditions and calculation method of generator loss-of-excitation protection by direct measuring power-angle.

以励磁故障后发电机端的相关参数的变化为基础，通过对以静稳定边界和异步阻抗边界作判据的两类三种现行励磁保护在原理上存在的缺陷分析，发现：励磁故障是一个大干扰稳定性问题，励磁故障后的发电机的动态功角特性与静态功角特性有很大的差异，已远非正弦曲线，因此基于小干扰稳定性原理、以静稳定边界作判据的保护必然动作不理想；异步边界阻抗判据是一个下移j Xd′的等无功阻抗圆，它可以保证完全失磁后的发电机测量阻抗能进入该阻抗圆，但不能保证完全失磁之外的其它状态不会进入该阻抗圆，因此在系统电压短时下降或发电机突然甩负荷等情况下可能启动该保护使之误动。

This paper mainly studies on people Jui-Tu neglected to look further into these questions.:one, through the works of Zhang Rui Figure comprehensive carding, so can their have a comprehensive understanding; 2, the morphological changes from the works start, to explore its origins calligraphy; 3, through their works shall know Handscroll analysis to help determine without the banners section in the approximate age of the work; 4 of their book to learn the concept of analysis, in order to more clearly understand the formation process of calligraphy styles. 5. Allograph home and at the same time learn the concept of the book, we can know that the formation of personality style and its concept of an independent study of the book is closely related to, but also deepen their understanding of the law of Zhang Rui.'s calligraphy.

本文主要就人们研究张瑞图时所忽略的一些问题做进一步的探讨：1、通过对张瑞图作品的全面梳理，以求能对其有一个全面的认识；2、从其作品的形态变化入手，探寻其书法的渊源，并尝试对其书法上一个很长的空白期进行探索；3、通过对其手卷作品进行款识分析，以帮助对无年款的条幅作品进行断代；4、对其书法观念进行论述，以求更清晰地理解其书法风格的形成；5、与同时代书家书法观念的比较，可以知道个性风格的形成与其独立的书学观念密切相关，更能加深对张瑞图书法的理解。

It showed that the halophile of Kenyu7 were better than Wuming-5;(2)the contents of proline of the two Zea mays varieties increased significantly,and under high NaCl stress(150mmol/L NaCl or above) the increasing amount of the contents of proline of Kenyu7 was higher than Wuming-5 ,so it showed that the injuries of Wuming-5 imposed by NaCl stress was greater than Kenyu7;(3)the activities of CAT of the two varieties were no obviously changed,while the activities of CAT of Wuming-5 were all higher than Kenyu7 under all concentrations of NaCl solution,which hadn't showed the correlation between the activity of CAT and salinity tolerance.

结果表明，随NaCl溶液浓度的增加：（1）两品种玉米生长均受到严重抑制，发芽势降低，芽和根的长度均呈减小的趋势，总体来看，杂交种垦玉7的发芽势、芽和根的长势均好于自交系无名-5；（2）两品种玉米体内Pro含量均增加，且在NaCl浓度超过150mmol/L时，杂交种垦玉7体内Pro含量增加的幅度明显大于自交系无名-5，而使垦玉7对盐的适应能力强于无名-5；（3）两品种的CAT活性变化幅度均不大，但无名-5的CAT活性在各NaCl浓度条件下均高于垦玉7，这可能是由品种间本身差异造成的，而与品种的耐盐性无直接关系。

The study showed the recombinant wt/mCREG protein depressed the VSMC proliferation depending on dose and the optimal concentration was 400nM;2biologic function of CREG protein and the membrance receptor mechanism:①effect on VSMC migration: the wound healing experiment showed the OB2 cells migration was slower significantly after added wt/mCREG(400Nm) in supernatant. The HITASY cells migration were very slowly and no remarkable change. The gelatinase digestion and Western blot analysis showed the matrix metalloproteinase was decreased and TIMPs was increased;②effect on differentiation: after added wt/mCREG(400nM), the expression of myocardin, SMα-actin, MHC and caldesmin were increased and that of LM-1 and FN were decreased in OB2 cells. These effects were more significant when adding wtCREG.;③effect on VSMC proliferation: Cell cycle assay and BrDU stain showed: after added the wtCREG and mCREG protein, the ratio of cell in G0/G1 phase increased to 0.5773 and 0.5572 from 0.5308 respectively in OB2 group, which increased to 0.7369 and 0.7034 respectively from 0.6297 in HITASY group;3Role of M6P/IGF2R in CREG biologic function:①ELISA and co-immunoprecipitation showed the wt/mCREG binding to M6P/IGF2R directly.②antibody blocking test: when the anti-IGF2R was added to medium at the same time with wt/mCREG at different concentration(2μg/mL、4μg/mL、8μg/mL),the effects of CREG protein which depressing proliferation, migration, secretion and promoting differentiation were blocked, which had the positive correlation to the concentration of added anti body. The studies showed two combinant CREG promoted VSMC switch to differentiation phaenotype, at the same time, depress VSMC proliferation, migration and secreting extracellular matrix.

上述实验结果证实：两种重组CREG蛋白对VSMC增殖均有剂量依赖性的抑制作用，并且相同浓度的糖基化的CREG蛋白对细胞增殖的抑制效应更为显著，最佳效应浓度为400nM；2两种重组CREG蛋白添加后对HITASY和OB2细胞生物学行为的影响：①CREG蛋白对VSMC迁移的影响：刮伤实验发现，加入最佳效应浓度的wtCREG和mCREG蛋白24h后，OB2组迁移能力下降，HITASY组无明显变化；细胞外基质金属蛋白酶-2，9(Matrix metallo-proteinase 2，9，MMP2 ，9)明胶酶电泳检测和Western blot检测结果证实，两种CREG蛋白均可以使OB2细胞合成细胞外基质MMP2，9减少，而组织金属蛋白酶抑制物(Tissue Inhibitors of Metalloproteinases，TIMPs)增加；②CREG蛋白对VSMC分化的影响：加入400nM的wtCREG和mCREG蛋白12h后，OB2细胞myocardin、SMα-actin、MHC、caldesmin表达增加，LM-1、FN表达减少；③流式细胞仪分析细胞周期和BrDU染色分析证实，加入400nM的wtCREG和mCREG蛋白后，OB2组G0/G1期细胞由0.5308分别增加至0.5773和0.5572，HITASY组G0/G1期细胞由0.6297分别增加至0.7369和0.7034；3M6P/IGF2R在重组CREG蛋白的生物学功能中的调控作用：①免疫共沉淀和免疫荧光双染色分析结果显示，CREG蛋白与M6P/IGF2R存在直接结合；②应用抗体阻断实验：将不同浓度的anti- M6P/IGF2R(2、4、8μg /mL)与两种CREG蛋白同时加入培养液中，CREG蛋白抑制VSMC增值、迁移和合成细胞外基质、促进分化的效应减弱，而且与加入anti- M6P/IGF2R浓度正相关。

In this paper, the 3-D finite element relocating mesh method is used to calculate the temperature field and the thermal creep stress field of spillway dam and mid level outlet dam in certain roller compacted concrete gravity dam, sensitivity analysis have been down with different parameters, such as placing temperature, the location of cooling pipe, cooling temperature, time for water supply, ascended-layer of concrete, intermissive time and different placing time, and the commendatory construction scheme have been put forward in such analysis; according by the test result on the two scheme of concrete aggregate combination (basalt as coarse aggregate and limestone as fine aggregate, basalt as coarse aggregate and basalt as fine aggregate), simulation analysis on temperature field and thermal creep stress field of the commendatory construction scheme have been down, and analysis have also been down on temperature field and thermal stress field of the two different aggregate combination, the result indicates that the spillway dam and mid level outlet dam which adopted these two aggregate combination can both satisfy the require of design crack resistance in concrete, furthermore limestone as fine is better than basalt as fine aggregate; the effect of summer water storage and winter water storage on the temperature field and thermal stress field have been analyzed, comparing with winter water storage, in summer water storage scheme the maximum tensile stress at abnormal concrete in upstream fill is decreased by 0.1～0.3MPa and there are no evidence change of the maximum tensile stress at other parts, which indicate that summer water storage is avail for the crack resistance of upstream fill; according to the simulation calculating result and comparing temperature simulation calculating results and temperature controlling measures of some similarity projects both completed and construction, synthesis appraise have been carried to the design temperature controlling measures of dam, and the temperature controlling measures of this project have been brought forward, all these have great reference value on the design of temperature controlling measures and the optimization of the construction scheme.

本文采用三维有限元浮动网格法仿真计算程序，对某碾压混凝土重力坝的溢流坝段和中孔坝段分别进行了三维有限元温度场和温度徐变应力仿真计算分析，对浇筑温度、冷却水管的布置方式、冷却水温、通水时间、浇筑升程和间歇时间、不同开始浇筑日期等参数进行了敏感性分析，在此基础上提出了推荐的施工方案；根据两种骨料方案(玄武岩粗骨料+灰岩细骨料方案；玄武岩粗骨料+玄武岩细骨料方案)的混凝土性能试验研究成果，对推荐的施工方案进行了温度场和温度徐变应力仿真计算，并对比分析了两种不同骨料情况下的温度场和温度应力，结果表明溢流坝段及中孔坝段采用上述两种骨料均能满足混凝土的抗裂设计要求，且灰岩细骨料优于玄武岩细骨料；计算分析了夏季蓄水和冬季蓄水对坝体温度场和温度应力的影响，夏季蓄水方案与冬季蓄水方案相比，坝体上游变态混凝土区域最大拉应力小0.1～0.3MPa，其他部位最大拉应力无明显变化，夏季蓄水对坝体上游面混凝土的抗裂有利；根据仿真计算成果并通过比较国内一些已建和在建的类似工程的温度仿真计算成果及采取的温控措施，对大坝的设计温控措施进行了综合评价，并提出了该工程的温控措施，对温控设计和优化施工方案具有重要参考价值。

The periostea of both experimental and control side of the mandibular ramus were taken and prepared, 2 of each 5 rabbits in a group were prepared for HE stain detection and 3 for proliferating cell nuclear antigen immunohistochemical detection.Results:1, The newly formed bone was detected on the lateral aspect of mandibular ramus after periosteal distraction. The bone was shaped like a hill. It looked very low and was full of holes at postoperative day 28. With the time of consolidation period lengthened, the newly formed bone matured gradually. X-ray examination showed the new bone shaped like a hill. The average values of new bone height at postoperative days 28,35,42 and 56 were 1.86 + 0.15mm, 2.29 + 0.29mm,3.19 + 0.13mm and 4.70 + 0.45mm. Histological examination of both HE stain and picricacid-fuchsin stain showed the increase in the number of osteoblasts and the change in the orientation of collagen fibers and bone trabecula. There were no significant differences between newly formed bone and original bone on the lateral aspect of mandibular ramus at postoperative day 56 histologically.2 Compared with the control side, the distracted periostea proliferated obviously under the microscope, and the number of periostealcells increased with satiation of cellular nuclear per unit area. The images of PCNA immunohistochemical stain of periosteum showed that the experimental periosteum proliferated obviously after distraction compared with the control side.

结果：骨膜牵张成骨的实验研究南京医科大学硕{学位论文l、骨膜牵张后，可见下领升支外侧的骨皮质上有新骨形成，新骨呈山峰状凸起，术后第28天的新生骨较低平，多孔隙，随着固定时间的延长，新骨逐渐成熟；下领升支前后向切线位X线投照显示新骨呈山峰样隆起；经测量，术后第28、35、42和56天组平均新生骨厚度分别为x.86士0.15mm、2.29士0.29mm、3.19士0.13mm和4.70 土0.45mm；脱钙骨组织的HE染色和不脱钙骨组织的苦味酸一品红染色的组织学观察均显示了新生骨在成骨细胞数量上的增长，以及胶原纤维和骨小梁排列方向上的变化，术后第56天的新生骨在组织学上与原升支骨组织已无明显区别。2、HE染色显示，与对照组相比较，实验侧骨膜增生明显，细胞间排列紧密，单位面积内骨膜细胞数增多，细胞核饱满；骨膜PCNA 免疫组化染色显示，与对照侧相比较，实验侧骨膜在牵张后出现了明显的增生迹象，PCNA阳性细胞分布紧密，单位面积内阳性细胞数较对照组多，靠近骨表面的骨膜中的阳性细胞数更多而且分布更为紧密。

objective trimetazidine has shown anti-ischemic properties to improve exercise tolerance without haemodynamic effects and direct cyto protective effect on the myocardium.however,it is not clear whether trimetazidine has beneficially effect on severe ischemic cardiomyopathy.methods 19patients（68±9）years with postnecrotic left ventricular dysfunction（ejection fraction31.7%±5.4%）were studied to examine the benefit of adding60mg a day of trimetazidine for3months to the classical therapy.the assessment included clinical evaluation,electrocardiography and echocardiography.results after adding60mg a day of trimetazidine for3months,attack of angina was relieved and dyspnea was improved（p.05）.but heart rate,systolic blood pressure,rate pressure product,ejection fraction,left ventricular volume and global wall motion index were not changed.conclusion trimetazidine seems to improve clinical status while can not change oxygen supply-to-demand ratio without adverse effects in patients on severe ischemic carˉdiomyopathy.

目的 曲美他嗪是一种新型的抗心肌缺血的药物，能够改善患者的运动耐量和心肌的直接保护作用同时并没有血流动力学效应。但目前对于严重缺血性心肌病患者的临床治疗价值还需要进一步观察。方法 19例（68±9）岁确诊为缺血性心肌病（左心室射血分数0%）的患者在常规治疗的基础上加用每日60mg曲美他嗪治疗3个月，随诊观察患者临床情况以及超声心动图指标的变化。结果 19例患者均可耐受在常规治疗基础上加用每日60mg曲美他嗪的治疗，随诊发现患者心绞痛发作明显减少，运动耐量明显改善。同时患者心率、收缩压、心率血压乘积、左心室射血分数、左心室容量以及整体室壁运动指数无明显改变。结论缺血性心肌病的患者在常规治疗基础上加用曲美他嗪是安全的，同时其能明显改善患者的临床状态，而这种作用并不改变心肌氧的供求比值。

Finally, the pH value, lactic acid, water soluble carbohydrate, ammonia nitrogen and cellulose contents were determined for WH silage prepared under the suitable adding doses of lactobacillus and cellulase at day 1, 3, 5, 15, 25, 35 after ensilaging. The pH value decreased from 5.5 before ensiling to 4.3 on the 35th ensiling day, whereas the reverse change tendence was observed for lactic acid content. The cellulose content of silage was lower from 26.5%DM in raw material to 22.3%DM.

结果表明：pH值由青贮前的5.5至青贮第35天时降至稳定的状态，而乳酸含量的变化趋势相反；凤眼莲茎叶纤维素含量从未青贮前的26.5%干物质，至青贮第35天降至22.3%干物质，降低了约4个百分点；青贮料中可溶性碳水化合物的含量随青贮时间的延长而逐渐下降，但是在第5天到第15天的时间段里，可溶性碳水化合物的含量无显著性下降；氨态氮占总氮的比例从青贮第1天的4.61%显著上升至第5天的8.25%，而从第5天开始到第35天，氨态氮占总氮的比例上升的幅度较小。

The growth relationship between spectrum parameter and fetch were studied, from which three parameters and overshot phenomenon that appears during wind wave spectra developing were tested, and an equation describing the growth of three-parameter spectra with wind wave was obtained With the equation, the spectra of wind waves were obtained at zero-dimensional fetches of 300, 500, 2000, 5500, 10000, and 15000, and the overshot was described more clearly. However, the overshot does not exist in the whole process of wind wave spectrum development as stated previously by Hasselmann, but in the early stage of the development only, extenuates with wave growth and then disappears when the wave fully grows.

基于已得到的谱参量随风区的变化关系，对三参量风浪频谱以及风浪频谱成长过程中存在的&超射&现象作深入的研究，得到三参量风浪频谱随风区的成长关系：在此基础上，得到无因次风区：300、500、2000、5500、10000、15000下，风浪频谱的谱线，从而直观地描述了风浪频谱成长过程中的&超射&现象，并认为在风浪频谱的成长过程中确实存在着&超射&现象，但是该现象并不如Hasselmann等提出的理论中阐述的那样存在于风浪频谱成长的全过程，而是仅存在于风浪频谱成长的初期。

Early researches have been limited to animal experiment of detecting metabolism of brain. With the development of magnetic resonance spectrum, studying in vivo has come ture on the biochemistry metabolism's level, which makes a new breakthrough for us to continue research of IGE afterward.

以往的研究仅限于动物实验的方法检测其脑内的代谢变化，现在随着磁共振波谱(Magnetic Resonance Spectroscopy， MRS)的应用，无创地从生化代谢水平上研究活体已成为现实，为这一类疾病的研究打开了新的局面。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐