无保护的

Would it be an unlicensed trespass of the imagination to conceive that on the night preceding the day of which you now commemorate the fiftieth anniversary--on the night preceding that thirtieth of April, 1789, when from the balcony of your city hall the chancellor of the State of New York administered to George Washington the solemn oath faithfully to execute the office of President of the United States, and to the best of his ability to preserve, protect, and defend the constitution of the United States--that in the visions of the night the guardian angel of the Father of our Country had appeared before him, in the venerated form of his mother, and, to cheer and encourage him in the performance of the momentous and solemn duties that he was about to assume, had delivered to him a suit of celestial armor--a helmet, consisting of the principles of piety, of justice, of honor, of benevolence, with which from his earliest infancy he had hitherto walked through life, in the presence of all his brethren; a spear, studded with the self- evident truths of the Declaration of Independence; a sword, the same with which he had led the armies of his country through the war of freedom to the summit of the triumphal arch of independence; a corselet and cuishes of long experience and habitual intercourse in peace and war with the world of mankind, his contemporaries of the human race, in all their stages of civilization; and, last of all, the Constitution of the United States, a shield, embossed by heavenly hands with the future history of his country?

是否会想象的无牌侵入的设想，在当晚的前一天你现在纪念成立五十周年-在当晚前的4月，1789年，第三十届时从您的市政厅阳台的校长纽约州管理的乔治华盛顿的庄严宣誓忠实地执行了美国总统的办公室，和他有能力保持最好，保护和捍卫美国宪法-，在愿景对我们国家的父亲晚上的守护天使出现在他面前了，在他母亲的尊敬形式，并以欢呼和鼓励的重大和庄严的职责，他对他承担的表现，已交付他西装天体装甲-头盔，虔诚的原则，正义，荣誉，仁爱，这从他与最早的婴儿，他至今走过的生命，他的所有兄弟的存在，组成； 1矛与自我独立宣言的真理镶嵌，剑，与他所带领的自由战争的独立凯旋门首脑会议的国家的军队一样，一个是胸衣和cuishes长期经验和在和平与人类世界的战争习惯性交，人类他同时代的，所有的文明阶段，以及最后的是，在美国，一个盾牌由天手饰的，宪法他的国家未来的历史？

On the basis of the kinetic equation of substrate reaction in the presence of urea or guanidine hydrochloride, all microscopic kinetic constants for the free enzyme and enzyme-substrate binary and ternary complexes have been determined. The results of the present studies indicate that:①In the presence of urea or guanidine hydrochloride, enzyme-substrate complexes lose their activity less rapidly than the free enzyme. Therefore, both substrates, NADPH and 7, 8-dihydrofolate, protect dihydrofolate reductase against inactivation.②The denaturation of dihydrofolate reductase by urea follows single-phase kinetics, and changes in enzyme activity and tertiary structure proceed simultaneously in the unfolding process, so it may be an"all or none"process.③The GdnHCl-induced unfolding of the dihydrofolate shows a biphasic transition, while the change in the enzyme activity is a single exponential process. The rate constant of inactivation is consistent with that of the fast conformational change. Therefore, the kinetic intermediate of protein unfolding should be a partially folded and inactive form.

我们根据在脲或盐酸胍存在下的底物反应动力学方程求得游离酶和酶底物二元、三元复合物的微观动力学常数，结果表明：①酶-底物二元、三元复合物的失活速度明显慢于游离酶，说明两个底物二氢叶酸和NADPH对酶的失活都具有一定程度的保护作用；②在脲作用下，酶的失活和构象变化均为单指数项过程，而且酶的活力丧失和三级结构变化是同时发生的，说明二氢叶酸还原酶的脲变性可能是一个"全或无"的两态过程；③在盐酸胍作用下，酶的构象变化为两相过程，而失活则是单指数项过程，酶分子构象变化的快相速度常数与失活速度常数基本一致，因此我们认为二氢叶酸还原酶的盐酸胍变性过程中存在一个没有活力、但仍具备一定空间结构的变性中间体。

The theories research:Reviewed the medical history of stroke\' s Pathogenesis and Modernrecognition on the pathomechanism of fushi syndrome of acute stroke; Exploredthe neuroprotective mechanism of tongfu treatment on acute stroke; Reviewedthe source of xuanfu theory and xuanfu pathogenesis of stroke. Proposed thattongfu could not only get through the gastrointestinal sthenia syndrome,butalso xuanfu; Explained the effect of AQP-4 in ischemic stroke pathogenesisand try to explore the intrinsic link between xuanfu and channel protein2. Clinical research: A retrospective case-control study was adopted, according to the diagnosis,inclusion and exclusion criteria, included in a total of 60 cases of acuteischemic stroke who hospitalized in one or three department of neurology inGuangdong Provincial Hospital of TCM from April 2005 to March 2007, used TFXSJN and unused TFXSJN was 30 casesrespective.

1理论研究：回顾了历代医家对中风病因病机的认识及近代医家对中风病急性期腑实证形成的病理机制的认识，探讨了通腑法治疗急性中风的神经保护机制；(来源：ABC论文18网www.abclunwen.com)回顾了玄府学说的历史渊源及中风病的玄府病机；提出通腑法所通的不仅仅是胃肠之腑，也包括无物不有的玄微之府；阐述了AQP-4在缺血性中风病理机制中的作用，并试图探讨玄府与通道蛋白之间的内在联系。2临床研究：采用回顾性病例对照研究，按照诊断、纳入及排除标准，纳入了2005年4月—2007年3月在广东省中医院神经一科及神经三科住院的急性缺血性中风患者共60例，其中使用TFXSJN及未使用TFXSJN者各30例。

objective trimetazidine has shown anti-ischemic properties to improve exercise tolerance without haemodynamic effects and direct cyto protective effect on the myocardium.however,it is not clear whether trimetazidine has beneficially effect on severe ischemic cardiomyopathy.methods 19patients（68±9）years with postnecrotic left ventricular dysfunction（ejection fraction31.7%±5.4%）were studied to examine the benefit of adding60mg a day of trimetazidine for3months to the classical therapy.the assessment included clinical evaluation,electrocardiography and echocardiography.results after adding60mg a day of trimetazidine for3months,attack of angina was relieved and dyspnea was improved（p.05）.but heart rate,systolic blood pressure,rate pressure product,ejection fraction,left ventricular volume and global wall motion index were not changed.conclusion trimetazidine seems to improve clinical status while can not change oxygen supply-to-demand ratio without adverse effects in patients on severe ischemic carˉdiomyopathy.

目的 曲美他嗪是一种新型的抗心肌缺血的药物，能够改善患者的运动耐量和心肌的直接保护作用同时并没有血流动力学效应。但目前对于严重缺血性心肌病患者的临床治疗价值还需要进一步观察。方法 19例（68±9）岁确诊为缺血性心肌病（左心室射血分数0%）的患者在常规治疗的基础上加用每日60mg曲美他嗪治疗3个月，随诊观察患者临床情况以及超声心动图指标的变化。结果 19例患者均可耐受在常规治疗基础上加用每日60mg曲美他嗪的治疗，随诊发现患者心绞痛发作明显减少，运动耐量明显改善。同时患者心率、收缩压、心率血压乘积、左心室射血分数、左心室容量以及整体室壁运动指数无明显改变。结论缺血性心肌病的患者在常规治疗基础上加用曲美他嗪是安全的，同时其能明显改善患者的临床状态，而这种作用并不改变心肌氧的供求比值。

Baby girl You know my situation And sometimes I know you get impatient But you dont put to on a show to get ovations Take it to court and go through litagations And I respect ya gangsta Treat you like a princess And put something on your neck to thank ya Shes my pinch hitta When the startin lineup aint playin right I come off the bench wit her It might sound like im gassin ya But it took time to get from the back seat to the passenger We been creepin and sneakin Just to keep it from leakin We so deep in our freakin That we dont sleep on the weekend Wifey A little bit uptight Wonderin why he comin home in the middle of the night Itll be alright if yall bump heads itll be a fight But i said itll be alright Come on I really wanna be with you be with you But I gotta be real with you real with you I cant leave you alone lone And I know I live and grown But i cant let ya go Your the one i want in my life want in my life Already got a wife got a wife Cant leave you alone lone And I know I live and grown But I cant let ya go You aint ever step out of line Or get out a pocket So i made sure canary sent out your locket To protect you, ill get out and cock it And you know the barrel of my gun is big enough to spit out a rocket Oh, you gonna play dumb if cops do come through I gotta keep the top up if my drop do come through But i know the boutiques and the shops you run through So i cop her one, and cop you one too You always get a daily page, weekly ring Plus you aint too shy to do them freaky things I aint gotta put a band on your finger I worry about you tellin the whole world im your new allen springer At first you were somethin i denied Something I would slide Just do somethin in the ride But shorty Theres something that you provide Cause the entre pain is good without somethin on the side You know I really wanna be with you be with you But I gotta be real with you real with you I cant leave you alone lone And I know I live and grown But i cant let ya go Your the one i want in my life want in my life Already got a wife got a wife Cant leave you alone lone And I know I live and grown But I cant let ya go Uh oh, i might be leavin the earth soon My girl gonna kill me if she smells the scent of your perfume Its gonna be a clip towards if I go back With stains of your lip gloss on my throwback She wont care if im a platinum rapper If she catch me with an empty magnum wrapper So keep it on the down low call the carsely You seen what happened with Mr. Big and R Kelly You know I get from you Anytime this chick is there for you Feelings imma share wit you Which makes it a Lil Mo clear for you x2 I really wanna be with you be with you But I gotta be real with you real with you

女婴 你知道我的处境有时候，我知道你不耐烦但你dont提出对表演获得掌声是否向法院经过litagations 我就帮遐把你像公主并提出一些对你的脖子谢遐畲族我捏hitta 当做起阵容并不是playin权我来替补，她风趣它听起来像即时几率遐但花时间从后座向乘客我们已经和creepin sneakin 刚刚把它从渗漏我们这么深的年freakin 我们dont睡上周末 wifey 有点紧张 wonderin为什么他搭档的家中半夜 itll予以好吧，如果男子跳车元首itll被扑灭但我说itll予以好吗来我真想与你与你但我干真正与你真正与你着我离开你独自独行我知道我的生活和成长但我让着去遐你的一个，我想在我的生命中希望我的人生已有一个妻子了妻子着离开你独自独行我知道我的生活和成长但我让着去遐你是不是有史以来走出线还是走出了口袋所以，我作了肯定的金丝雀寄出你的头发为了保护你，生病走出它公鸡你知道枪管的枪，我是足够大吐出火箭哦，你再拖扮演哑巴，如果警察不来，通过我干随时补足，如果我落不来通过但我知道，专卖店和商铺，你流经所以她的缔约方之一，并缔约方之一，你太你总是得到页每日，每周响另外你是不是太害羞做事情freaky 我并不是干把带手指我担心你tellin全世界即时你的新阿伦螺旋藻起初你somethin本人否认我将下滑刚做somethin在坐但shorty 照片theres东西，你提供造成entre痛是好的无somethin对方你知道我真想与你与你但我干真正与你真正与你着我离开你独自独行我知道我的生活和成长但我让着去遐你的一个，我想在我的生命中希望我的人生已有一个妻子了妻子着离开你独自独行我知道我的生活和成长但我让着去遐呵哦，我可寄至地球快我的女孩再拖杀了我，如果她的气味香，你的香水其再拖剪辑走向，如果我回去污渍与你唇光泽我倒退她で照顾，如果即时白金唱片如果她追上我用空枕包装所以保持对低下来致电carsely 你看到发生了什么大先生和r凯利你知道我从你随时这只小鸡有你投书感受分享您智慧这使它成为莫律清楚，你χ2 我真想与你与你但我干真正与你真正与你但我干真正与你真正与你着我离开你独自独行我知道我的生活和成长但我让着去遐你的一个，我想在我的生命中希望我的人生已有一个妻子了妻子着离开你独自独行我知道我的生活和成长但我让着去遐我真想与你与你但我干真正与你真正与你着我离开你独自独行我知道我的生活和成长但我让着去遐你的一个，我想在我的生命中希望我的人生已有一个妻子了妻子着离开你独自独行我知道我的生活和成长但我让着去遐

The results indicated that the accumulation of Mn in the cell wall (accumulation rate as high as 36.34%) and the vacuole of the leaves (accumulation rate as high as 65.64%) might be one of the mechanisms of tolerance and hyperaccumulation of Polygonum hydropiper to Mn. Most Mn in leaves were the speciation of H2O-solubility organic salts or manganese oxalates. The content of chlorophyll a did not change under different Mn concentration treatments except that its content decreased remarkably when Mn concentration was 8000μmol/L in solutions. The membranes were not banned by Mn when its concentration was less than 5000μmol/L in solutions; Under different Mn concentrations of Mn, the content of their soluble proteins of leaves had changed at some stage. The activity of SOD and POD were gradually improved with the increasing of Mn concentration, which could eliminate activated oxygen free radical, This might be the other physiological mechanism of tolerance and hyperaccumulation of Polygonum hydropiper responding to Mn.

结果表明：锰在水蓼叶片非活性代谢部分的积累是其解毒耐锰的主要机制之一；水蓼叶片中的锰大部分以水溶性有机盐或草酸锰的形态存在；在锰浓度处理为8000μmol/L时，叶绿素a含量显著降低，而在其它处理条件下，叶绿素a无明显变化；在锰处理≤5000μmol/L时水蓼叶片的细胞膜还没有受到明显伤害；水蓼叶片的可溶性蛋白含量随锰处理浓度不同而变化，说明植物在代谢和结构上发生了调整；随锰处理浓度的增加，水蓼叶片SOD和POD活性提高，保护酶活性的提高又可清除活性氧自由基，这是水蓼耐高锰和累积锰的一种生理响应机制。

The percentage of strong positive expression of MUC2 in SSDH group, slightly higher than it in SSW group , which may indicate a diminishing trend of the expression of MUC2,which might prompt the direction of the development of the disease ,and could provide a valuable signal on the disease prognosis and treatment.

脾胃湿热组、脾胃虚弱组MUC2表达无显著性差异，但脾胃湿热组MUC2的强阳性表达率较脾胃虚弱组略高，这可能说明脾胃湿热证和脾胃虚弱证之间粘蛋白的表达呈递减的趋势，即肠粘膜的防御保护功能下降，而这种递减可能提示了疾病发展的方向，可能对疾病的转归及临床治疗提供有价值的预示。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。