无

Results:①All gallstones type Ⅰ and Ⅳ in animal models were dissolved quickly, however, MTBE showed somewhat toxicity in inhibiting CNS, so that the dose of MTBE should be controlled precisely.②No abnormal change of liver and renal functions of dogs were found before and after operations.③Choloecyst pathological sections of gallbladder suggested that no evident of damage and inflammation of gallbladder was of found. Hemopexis with reversible histological change was observed in hepatic sinusoid and centeral vein short time after administation of MTBE.

结果：①动物模型的Ⅰ、Ⅳ型结石均全部迅速溶解，但MTBE有一定毒性，其对中枢神经系统有一定的抑制作用，应用时须严格掌握单位时间内的灌注剂量及总量(控制在60ml左右)；②实验犬实验前后的肝、肾功能检查无异常；③病理检查结果提示MTBE对胆囊组织无明显损伤，无严重炎性反应，给药后短期内肝窦和中央静脉有凝血现象，但其组织学变化是可逆的。

Petiole 0.8-1.2 cm, glabrous; leaf blade elliptic to oblong-elliptic, 7-12(-16)× 2.5-4.5(-5.5) cm, leathery, abaxially pale green, brown glandular punctate, hirtellous near base especially along midvein but glabrescent, and becoming yellowish brown when dry, adaxially dark green,± rugulose, and glabrous, midvein, secondary, and reticulate veins abaxially raised and adaxially impressed, secondary veins 8 or 9 on each side of midvein, base broadly cuneate to obtuse, margin bluntly denticulate, apex shortly acuminate to acuminate. Flowers subterminal, solitary, ca.

叶柄0.8-1.2厘米，无毛；叶片椭圆形到长圆形椭圆形， 7-12(-16)* 2.5-4.5(-5.5)厘米，革质，苍绿色，棕色腺体具点，具微糙硬毛的近基部特别是沿中脉但是后脱落，并且干燥时成为黄棕色，正面深绿色，多少微皱，并且无毛，中脉，次脉，和网脉背面突起和正面凹陷，次脉在中脉两边各8或9，花近顶生，单生，直径约4厘米，近无柄。

Stipules green, falcate, rarely ovate or ovate-lanceolate, herbaceous, margin sharply serrate or lobed, rarely entire, apex acute or acuminate; petiole sparsely pilose or pubescent; leaf blade interrupted imparipinnate with (2 or)3 or 4 pairs of leaflets, reduced to 3 leaflets on upper leaves; leaflets sessile or shortly petiolulate, obovate, obovate-elliptic, or obovate-lanceolate, 1.5–5 × 1–2.5 cm, abaxially appressed pilose on veins, or densely pubescent or tomentose-pubescent between veins, rarely glabrescent, markedly or sparsely glandular punctate, adaxially pilose, or hirsute or hirtellous on veins, rarely glabrescent, base cuneate to broadly so, margin acutely to obtusely serrate, apex rounded to acute, rarely acuminate. Inflorescence terminal, spicate-racemose, branched or not; rachis pilose.

绿色，镰刀形的托叶，卵形或卵状披针形的很少，草本，边缘锐切成锯齿状或者有叶，很少全缘，先端锐尖或渐尖；叶柄疏生柔毛或短柔毛；叶片间断奇数羽状具(2或)3或4小叶，退化至3小叶在上部叶片上；短的小叶无柄或具小叶柄，倒卵形，倒卵状椭圆形，披针形或倒卵形， 1.5-5 * 1-2.5 厘米，背面的贴伏的具柔毛的在脉上，在脉之间的或密被短柔毛的或被绒毛的短柔毛，很少脱落无毛显著具点，正面具柔毛的或疏生腺体，或具粗毛或在脉上，很少脱落无毛，基部楔形到宽楔形，花序顶生，穗状总状，与否的分枝；轴具柔毛。

Days Daughters of Time, the hypocritic Days, Muffled and dumb like barefoot dervishes, And marching single in an endless file, Bring diadems and faggots in their hands. To each they offer gifts after his will, Bread, kingdoms, stars, and sky that holds them all.

日子 光阴老人的女儿，伪善的时日，喑哑无语如同赤足的托僧，她们单行排列，无始也无终，手托皇冠和一根根权杖，按各人的心愿向大家分赠礼品，面包，王国和包罗星辰的天空。

Paper 2:Mutation analysis of EDA gene in Chinese families with X-linked hypohidrotic ectodermal dysplasiaX-linked hypohidrotic ectodermal dysplasia(XLHED,MIM305100) is a recessive disease characterized by severe hypohidrosis,hypotrichosis and hypodontia.

论文二X连锁无汗/少汗型外胚层发育不良中EDA基因致病突变鉴定X连锁隐性无汗/少汗型外胚层发育不良(X-linked anhidrotic/hypohidroticectodermal dysplasia，XLHED；MIM305100)是无汗/少汗型外胚层发育不良(anhidrotic/hypohidrotic ectodermal dysplasia，EDA)中最常见的一种，约占95%。

Results are as followed:1 Exposure of HELF cells to BP caused c-Jun activation,and increased the activity of MAPK,PI-3K,p53 and cyclin D1 pathway.2 BP-induced c-Jun activation was inhibited by dominant negative mutants of extracellular signal-regulated protein kinase or c-Jun NH_2-terminal kinase,but not by p38,impling that JNK and ERK pathways medicate c-Jun activation induced by BP.3 Overexpression of dominant-negative mutants PI-3K and Akt potently blocked phosphorylations of c-Jun and ERK,but not JNK in response to BP,suggesting that PI-3K/Akt pathway positively regulates BP-induced c-Jun activation through ERK.4 Inhibition of p53 by its chemical or molecular inhibitor markedly increased the phosphorylation levels of c-Jun,Akt and ERK upon BP stimulation,indicating that p53 negatively medicates BP-induced c-Jun activation through PI-3K/Akt/ERK pathway.5 The cell lines expressed TAM67 exhibits no significant affecting normal cell growth properties.6 TAM67 was able to significantly block G_1-S transition and subsequent cell proliferation,suggesting that c-Jun is essential for cell cycle alternations elicited by BP.7 Overexpression of TAM67 impaired BP-induced cyclin D1 activation,decreasing expression of E2F1 and pRb,indicating that c-Jun participates in the modulation of BP-induced activation of cyclin D1/pRb/E2F1 pathway.8 Stably expression of TAM67 led to the increases in the expression levels of p53 and p21,elevating phosphorylation level of p53,clearly indicating that c-Jun regulates p53/p21 pathway activation induced by BRCollectively,PI3K/Akt/ERK pathway mediated BP-induced c-Jun activation through p53-dependent mechanism.

结果显示：1BP刺激细胞可促进c-Jun活化，并伴随着MAPK、PI-3K、p53和cyclinD1通路各组成成分的活性增强。2利用MAPK通路的显性失活突变体分别阻断细胞外信号调节激酶和c-Jun氨基末端激酶活性，均可明显抑制BP诱导的c-Jun活化，但阻断p38活性对BP引起的c-Jun活化无明显影响，提示JNK和ERK通路参与调控BP诱导的c-Jun活化。3过表达PI-3K和Akt的显性失活突变体也可显著抑制BP诱导的c-Jun活化，并降低磷酸化ERK的表达水平，但对磷酸化JNK的表达水平无明显影响，说明PI-3K/Akt通路通过ERK正性调控了BP诱导的c-Jun活化。4p53的化学/分子抑制剂能使BP作用的细胞内c-Jun活性明显增加，并同时诱导Akt和ERK的磷酸化水平的升高，表明p53可通过PI-3K/Akt/ERK通路对BP诱导的c-Jun活化进行负性调控。5随后观察转染细胞的生长情况，发现TAM67对细胞正常生长和形态无明显影响。6稳定表达TAM67可有效抑制BP诱导的S期细胞数的增加，提示c-Jun在BP致细胞周期改变的过程中发挥了重要作用。7TAM67过表达能够抑制BP诱导的cyclin D1活化，降低磷酸化Rb以及E2F1蛋白表达水平，表明c-Jun参与调控BP诱导的cyclin D1/Rb/E2F1通路的活化。8过表达TAM67可使BP刺激的细胞中p53、p21总蛋白以及p53磷酸化的表达水平明显升高，可见c-Jun也参与调控BP诱导的p53/p21通路活化。

Observed the cause, time, general conditions of patients, vital disease, whether or not electrolyte failure, dose of adrenaline, whether or not introthoracic caidiac massive and electro defibralation, mechanical ventilation of cardio arrest.

成功组 3 0例，失败组 16例。观察其心脏骤停发生的原因、时间、病人的一般情况、有无重要脏器疾病、有无电解质紊乱、肾上腺素用量、有无胸心心脏按压及电除颤、机械通气。

So, some researches are present in this paper: 1 In this paper, a finite element model of curved box girder jointless bridges supported on piles is brought forward, considering the interaction between structure and soil.

本文就无伸缩缝曲线箱梁桥剪力滞效应的分析开展了如下的研究： 1、考虑桩土效应，建立无伸缩缝曲线箱梁桥有限元模型，研究在不同荷载下无伸缩缝曲线箱梁桥剪力滞系数的分布规律。

The results were expressed in mean±1SD. Pearson X~2 test and One-way ANOVA test were used. The data analyzed using the SPSS (version 11.5). Results: The sensitivity, specificity, positive and negative value of US for the LPEH model on the children cadaver were 88%, 84%, 79%, 91%, respectively. With regard to the thickness of femora head cartilage, the thickness of the anterior layer or posterior layer, there were no significant differences among three groups. However, the anterior layer was thicker than the posterior layer in three groups. The fluid in hip joint was detected in all of 21 symptomatic hips, which was clear commonly (90%) in early procedure. The amount of fluid in anterior recess showed a positive correlation with age (p .05). No fluid was detected in the asymptomatic and normal hips (2mm). The mean maximum width of inferomedial recess was significantly larger than that of anterior recess (12.50±4.04mm vs.4.35±0.8mm, p 0.05) in the symptomatic hip joints. The echogenic entrapped labral plicaes were demonstrated in the inferomedial recess in all of 21 children with LPEH, whose length and width ranged from 5.3mm-25.0mm (mean,15.6±5.6mm) and from 4.0mm-17.0mm (mean,8.9±7.8mm).

结果1，尸体LPEH髋关节模型的超声诊断敏感性、特异性分别为88％、84％，阳性预测值、阴性预测值分别为79％、91％。2，21例患儿的LPEH患髋(21侧)、健髋(21侧)，以及21例正常儿童健髋(42侧)的超声检查显示：髋关节周围软组织及股骨头无形态结构差别；股骨头软骨厚度无统计学差异(3.5±0.5mm vs.3.6±0.4mm vs.3.6±0.5mm，p＞0.05)；关节囊前层及后层厚度无统计学差异(前层厚度2.79±0.74 mm vs.2.56±0.40mm vs.2.56±0.72mm；后层厚度2.70±0.82mm vs.2.48±0.54mm vs.2.44±0.58mm，p＞0.05)，但LPEH患髋关节囊前、后层均较后二组有增厚趋势。3，LPEH患髋均存在关节腔内积液，且早期较为清晰；积液以髋关节内下间隙明显，内下间隙较前间隙明显增宽(12.50±4.04mm vs.4.35±0.8mm，p＜0.05)，其内见嵌顿滑膜唇皱襞呈稍强回声的占位性团块，长约15.6±5.6mm，宽约8.9±7.8mm，90.5％(19／21)嵌顿皱襞内未见血流信号。4，所有LPEH患髋治疗后超声复诊均显示正常。

Fruit dehiscent siliques, linear or oblong, terete or rarely slightly latiseptate, sessile; valves papery, with an obscure midvein, torulose; replum rounded; septum complete, membranous, translucent, veinless; style absent or distinct and to 1 mm, cylindric or clavate; stigma capitate, entire.

果开裂长角果，具宽隔膜的线形或长圆形，圆柱状的或很少稍，无梗；裂爿纸质，具一不明显，近念珠状；假隔膜绕行；隔膜完成，膜质，半透明，无脉；称呼无或离生和在1毫米，圆筒状或；柱头头状，全缘。

And discuss some key point of integrated management system design, include hazard identification and risk assessment and risk control in the occupational health and safety management, the measure of satisfaction target of customer, the flawlessness of law system, the integration of the integrated management system and enterprise standardization system, unify lead institution and work orgnization, integreted internal audit and integrated management review.

同时，论述了一体化管理体系构建中的几个主要问题，包括职业健康安全管理中的危险源辨识、风险评价和风险控制、顾客满意度的科学监测、法律、法规体系的完善、一体化管理体系与企业标准化体系的有机结合、统一的领导机构和工作机构、一体化的内部审核和管理评审。

Deepwater Taranaki is investigated for its petroleum potential, using all available seismic data tied to shallow-water wells.

运用与浅水井相关的现有全部震波探测数据考察了深海区塔拉纳基盆地的油藏前景。