新霉素

Produced from strains of the actinomycete Streptomyces fradiae and used especially in the form of its sulfate as an intestinal antiseptic in surgery.

新霉素链菌素，尤其指它的硫酸盐形式，在手术时用作肠道杀菌剂

In this study,we focus on the interaction between nuclear modifier gene MTO2 and aminoglycosides,and have received the following innovations.1,We here report first that the knockout of MTO2 significantly inhibited mtDNA p_(454)~R mutant's sensitivity to aminoglycoside antibiotics.Here are the results:(1)In neomycin GYP medium,when mitochondria genes were wild type,whether MTO2 knockout or not,the growth of yeast strains has no significant difference;when mitochondria genes were complete deletion,whether MTO2 knockout or not,the growth of yeast strains also has no significant difference;Interesting,when mtDNA P_(454)~R,wild-type MTO2 strains were hardly survival in neomycin GYP medium,but the growth of MTO2 knockout strains were only partly inhibited,there was a significant difference performance of neomycin sensitivity between them.

具体结果如下：(1)在含有新霉素的葡萄糖培养基上，mtDNA为野生型、MTO2敲除与否，相应的酵母菌株的生长没有显著差异；mtDNA完全缺失、MTO2敲除与否，相应的酵母菌株的生长也没有显著差异；然而，当mtDNA存在P_(454)~R突变时，MTO2野生型菌株几乎完全不能生长，而MTO2敲除菌株的生长只受到部分抑制，表现二者对新霉素的敏感性存在显著差异。

The neomycin possess the powerful capability of eleminating vestibular hair cells of adult rat;Neomycin intracochlear administration via scale tympani can develop an ideal vestibular dysfunction animal model.Ⅱ.

新霉素对大鼠前庭毛细胞具有毁灭性的破坏作用，新霉素耳蜗内注射的方法可以建立理想的前庭功能障碍动物模型。

Its molecular structure js beta-methyl indole-3-propionic acid, containing no thiopyran ring, which is a characteristic moiety of Chuanxinmycin.

脱硫创新霉素是创新霉素经过脱硫反应生成的一个创新霉素衍生物，其分子结构为β-甲基吲哚丙酸，不含创新霉素所特有的噻喃环。

bFGF protected guinea pig utricular hair cells from Neomycin injury in vitro.

新霉素对离体的椭圆囊毛细胞有较强的破坏作用；bFGF对新霉素所致离体椭圆囊毛细胞的损伤有保护作用。

Results A significantly higher number of survival utricular hair cells was seen in experimental group(P＜0.05),as compared with control group.Conclusion bFGF protected guinea pig utricular hair cells from Neomycin injury in vitro.

结果 含bFGF的实验组毛细胞的存活数目显著高于不含bFGF的实验组P结论新霉素对离体的椭圆囊毛细胞有较强的破坏作用；bFGF对新霉素所致离体椭圆囊毛细胞的损伤有保护作用。

Control Efficacy of Neomycin against Several Bacterial Plant Diseases and Its Acute Toxicity HE Yan, TAO Ke, HUANG Xiao, CUI Wen-hua, ZHANG Xin-gang, HOU Tai-ping (Institude of Pesticide and Crop Protection, College of Life Sciences, Sichuan University, Chengdu 610064, China) Abstract: The control efficacy of neomycin is comparative with streptomycin using the potted plant experiment, with control efficacies of 77.55% in soft rot of cabbage, 77.55% in ginger blast, 69.07% in rice white leaf blight, 80.51% in citrus canker, at the concentration of 200 mg/L.

新霉素对植物病原细菌的防效及其急性毒性贺燕，陶科，黄晓，崔文华，张新刚，侯太平(四川大学生命科学院，农药与作物保护研究所，成都 610064)摘要：室内盆栽试验表明，新霉素与农业上常用的杀菌剂农用链霉素的防效相当，200 mg/L防治大白菜软腐病防效为77.55%，姜瘟病防效为77.55%，稻白叶枯病防效为69.07%，柑桔溃疡病防效达80.51%。

Using the proposed method, neomycin concentration in several water samples spiked with neomycin and a neomycin sulfate ear drop were determined.

将本研究建立的方法应用于几种环境水体和市售新霉素滴耳液中新霉素含量的检测。

objective to study the infection and sensitivity to antimicrobial agents of staphylococcus of bacterial prostatitis patients.methods the results of bacteriology and drug susceptibility of 421 patients,who were suffered from prostatitis,were analysed retrospectively.results in the 421 succus prostaticus samples,278 strains pathogenic microorganisms of 15 genera were isolated from the 273 succus prostaticus samples,and the major pathogenic microorganisms was staphylococcus aureus(57.2%) and coagulase negative staphylocous（17.3%.the drug resistance rate of staphylococcus to penicilling,erythromycin and albomycin was 88%-97%,and it was 33%-50% to fluoroquinolones.the drug resistance rate of staphylococcus to amikacin,cefazolin,nemycin,rifampicin and cefoperazone was lower than 30%,and they all appeared susceptible to vancomycin.conclusion staphylococcus is the main germ of bacterial prostatitis and it appears high drug resistance to usual antibacterials.staphylococcus is susceptible to vancomycin,amikacin,cefazolin,neomycin,rifampicin and cefoperazone.

目的 探讨细菌性前列腺炎患者葡萄球菌的感染状况及抗菌药物敏感性。方法回顾分析421例前列腺炎患者标本的细菌学和药物敏感性试验结果。结果 421例前列腺液标本，273例分离出细菌，共分离出15个种别共计278株病原菌，其中金黄色葡萄球菌占57.2%，凝固酶阴性葡萄球菌占17.3%；葡萄球菌对青霉素g、红霉素、白霉素耐药率为88%～97%，对氟喹诺酮类耐药率为33%～50%，对丁胺卡那霉素、头孢唑啉、新霉素、利福平和头孢哌酮耐药率均0%，对万古霉素全部显示敏感。结论葡萄球菌是细菌性前列腺炎的最常见病原菌，对临床常用抗菌药物具有较高的耐药性，葡萄球菌对万古霉素、丁胺卡那霉素、头孢唑啉、新霉素、利福平和头孢哌酮较为敏感。

The use of neomycin on a large scale as a therapeutic agent gives rise to drug residues in edible products of animals, which can adversely affect the public health and environmental safety.

新霉素的广泛应用引发了动物食品内日益严重的残留问题，因此，新霉素的残留分析和控制显得愈发重要。

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了