新生霉素

An antibiotic, C31H36N2O11, produced by the actinomycete Streptomyces nivens and used to treat infections by gram-positive bacteria.

新生霉素抗生素，c31h36n2o11，由放线菌产生雪白链霉菌，并可用于治疗革兰氏阳性菌引起的传染病

Those pathogens were susceptible to ciprofloxacin and novobiocin, however resistance to penicillin C, streptomycin, bacitracin and polymyxin B was produced.

这些致病菌对环丙沙星、新生霉素等药物有很高的敏感性，而对青霉素、链霉素、杆菌肤和多粘菌素已经产生耐药性。

ABSTRACT: Objective To study the antitumor activity of noviose and coumarin in novobiocin.

目的 研究新生霉素的结构单元诺维糖和香豆素的抗肿瘤活性。

Noviose and coumarin have a little antitumor activity but it is weaker than novobiocin.

化合物2和化合物3具有抗肿瘤活性，但比新生霉素弱。

In order to find new kinds of antibacterial agents, a primary screening model has been set with the DNA gyrase B subunit as a target, and then the active compounds of positive strain were purified. From Mycobacterium phlei, we isolated a novobiocin supersensitive mutant M.phlei SS12 and a resistant ~mutant M.phlei RR11 with NTG and UV.

实验采用Mycobacteriumphlei为出发菌株，利用NTG和紫外线复合诱变得到新生霉素特异性的超敏菌株M.phleiSS12和耐药菌株M.phleiRR11，建立了以DNA回旋酶B亚基为靶点的抗结核药物的筛选模型；并应用此模型对1600株真菌和100株放线菌发酵液进行了初筛，获得了38株阳性菌，阳性率为2.4%；对阳性菌株3277的发酵液进行了提取分离，得到X1和X2两个活性化合物。

Objective To study the antitumor effect of novobiocin on patients'primary liver cancer cells, and the modulation of NOVO on some clinical antitumor drugs.

目的 研究新生霉素对人肝癌细胞的抗癌及其对临床常用抗癌药的调节作用。

Noviose and coumarin have a little antitumor activity but it is weaker than novobiocin.

化合物2和化合物3具有抗肿瘤活性，但比新生霉素弱。中国诺宇综合网http：//www.siaaa.com

Results The half maximal inhibitory concentration(IC50): compound 2 was 2.287 mmol/L, compound 3 was 2.165 mmol/L, novobiocin was 0.350 mmol/L.

结果 化合物2的IC50为2.287 mmol，化合物3的IC50为2.165 mmol，新生霉素的IC50为0.350 mmol。

Methods Synthesis 3-O-carbamylnoviose and 3-acetamido-7-hydroxycoumarin, compare the activity of inhibit K562 cell with novobiocin by MTT.

合成新生霉素的结构单元3-O-氨基甲酰基诺维糖（化合物2）和3-乙酰氨基-7-羟基香豆素（化合物3），MTT法测定两化合物与新生霉素抗K562细胞的活性。

We synchronized the wheat cell suspension cultures, then added Novobiocin—an inhibitor of TopoⅡ to the cell suspension, changs of the ratio of M/T were observed within 48 hours.

用aphidicolin使小麦悬浮系细胞同步化，然后向细胞培养液中加入TopoⅡ抑制剂新生霉素，48小时内观察分裂中期细胞比率的动态变化。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。