新生物

In this paper, the progresses of researches and applications of the immobilized lipase and whole cell biocatalyst in the production of biodiesel,glycerine recycling and new craft of catalyst regeneration are summarized.

本文综述了固定化脂肪酶，全细胞生物催化剂在生物柴油制备中研究应用的新进展。关键词：生物柴油；固定化脂肪酶；全细胞生物催化剂

GEN is the source for news on biotechnology, bioregulation, bioprocess, bioresearch and technology transfer. In addition to news and feature articles, each issue of GEN includes BioProcess Tutorials, New Products, Wall Street Biobeat, Clinical Trials Update, Collaborations and Agreements, University Gene Beat, People, Calendar and Biotechnology on the World Wide Web.

同时基因工程新闻网也是生物技术，生物调控，生物处理，生物研究和生物技术转化类新闻的主要提供者，其它还包括生物加工指南，新产品，临床试验最新信息，合作与交流，以及互联网上人及生物技术类信息。

Biopolymer active center elements are the composition of the alimental organism and the primary inherent cause of catalysis and activation, their ingestion, accumulation, transportation and distribution have relation to the biological function of the organism, so we can predict the characteristics of the elemental distribution by the fourth statistical mechanics founded by Professor Jin and further study the biological function of the organism with diet therapy effect.

由于生物高分子活性中心元素是生物营养体的组成成分与催化激活的主要内在原因，其摄入，积累，运送与分布都与生物体的生物功能密切相关，所以可以通过金日光教授提出的第四统计力学——群子统计理论来考察其分布规律，进而考察、评价食疗型生物体的生物功能，从而为研究生物体的营养、药物功能提供新的理论依据，为诠释中国传统食疗学的相关理论打开新的思路。

The extinction or appearance of these Ostracoda always occurred in a short time interval, and can be correlated locally and globally, so they are of importance in bioeventstratigraphy. This article listed six such biological events in Qaidam Basin and discussed their causes. The extinction of Cetacella reflected temperature decrease at global scale and changes of palaeoclimate zones during the latest Jurassic and the earliest Cretaceous; The rapid decline of Cypridea in the earliest Cretaceous may be a result of the strikes of small planets; at the latest middle-Eocene Austrocypris became extinct, and at Oligocene Hemicyprinotus disappeared. These events related to the changes of the geological conditions at that time. The explosion of Cyprideis at the middle-Miocene was because the rise of Qinghai-Xizang Plateau which resulted in the dry climate and development of salt lakes.

这些水生生物的绝灭或发生均很迅速，在区域或全球范围内均可对比，具有生物事件地层学意义：Cetacella属的绝灭可能是侏罗、白垩纪之交全球性的古气候降温和气候带变化在柴达木盆地的反映；早白垩世之后Cypridea的迅速衰退是地外因素灾变的结果；中始新世晚期的Austrocypris的绝灭、渐新世Hemicyprinotus的绝灭都与当时地质条件的改变存在著内在的联系；中中新世Cyprideis的爆发推断是青藏高原隆升，导致气候乾燥、湖水咸化的结果；而晚更新世晚期1。

Four aspects of research achievements include:(1)several imaging correction methods and strained estimation methods for biological tissues elasticity imaging were investigated as well as elasticity reconstruction and phantom, in vitro and in vivo elasticity imaging experiments;(2)in the fields of biological microsystem and perfusion evaluation for microvascular system, three kinds of microbubbles whose shell are albumin, sugar ester and surfactant respectively were designed and produced, then the methods to estimate the thickness of their shells were presented, moreover, the interacting mechanism of ultrasound contrast agents and tissues, as well as protein drug delivery under the condition of ultrasound sonification were studied in the molecular level;(3) At the aspect of high intensity focused ultrasound therapy system, we designed and constructed the 256-element HIFU transducers using 1-3 composite materials. And furthermore we developed the integrated HIFU system with 256-element HIFU transducers. And we made preliminary and important progresses in the research of HIFU bioeffect, lesion estimation, techniques of monitoring and imaging and characterizing of structure of HIFU transducer;(4)The real-time method of voice source regeneration based on compensative regulation of physiological parameters was investigated in the field of medical rehabilitation. We addressed the physiology and biophysics of vocalization, modeled voice source regeneration based on compensative regulation mechanism, and put forward an integrated evaluation about the speech rehabilitation and the regenerated voice source; Sixty-one archived journal papers were published, as well as ten in international journals, and eighteen publications were embodied by SCI.

成果包括：（1）在生物组织弹性成像方面，研究了多种图像校正方法和应变估计方法，进行了弹性重构和仿体、离体及在体超声弹性成像实验研究；（2）在生物微系统和微血管血流灌注成像方面，制备了三种不同包膜超声造影微泡，研究了纳米包膜厚度检测与估计方法以及不同纳米包膜造影微泡断裂与药物释放机制，并在分子层次上开展了超声与生物组织相互作用机制以及蛋白质药物超声乳化微囊包裹的研究；（3）在阵列式高强聚焦超声治疗与监控成像技术方面，设计制作了新的HIFU换能器，解决了256阵元单焦点和多焦点合成HIFU治疗系统关键技术问题，并在HIFU生物效应与创伤性评价方法、HIFU过程监控成像技术和薄层复合结构与HIFU 换能器界面特性评价等方面的研究取得了初步而重要的进展，具有重要应用前景；（4）在语音听觉系统特别是嗓音康复方面，研究了基于发声系统补偿调节机制的实时多模式嗓音源再生方法和发声生理，建立基于神经、肌肉和空气动力系统的综合补偿调节模型，提出了相应的评价系统。

Four aspects of research achievements include:(1)several imaging correction methods and strained estimation methods for biological tissues elasticity imaging were investigated as well as elasticity reconstruction and phantom, in vitro and in vivo elasticity imaging experiments;(2)in the fields of biological microsystem and perfusion evaluation for microvascular system, three kinds of microbubbles whose shell are albumin, sugar ester and surfactant respectively were designed and produced, then the methods to estimate the thickness of their shells were presented, moreover, the interacting mechanism of ultrasound contrast agents and tissues, as well as protein drug delivery under the condition of ultrasound sonification were studied in the molecular level;(3) At the aspect of high intensity focused ultrasound therapy system, we designed and constructed the 256-element HIFU transducers using 1-3 composite materials. And furthermore we developed the integrated HIFU system with 256-element HIFU transducers. And we made preliminary and important progresses in the research of HIFU bioeffect, lesion estimation, techniques of monitoring and imaging and characterizing of structure of HIFU transducer;(4)The real-time method of voice source regeneration based on compensative regulation of physiological parameters was investigated in the field of medical rehabilitation. We addressed the physiology and biophysics of vocalization, modeled voice source regeneration based on compensative regulation mechanism, and put forward an integrated evaluation about the speech rehabilitation and the regenerated voice source; Sixty-one archived journal papers were published, as well as ten in international journals, and eighteen publications were embodied by SCI.

中文摘要：成果包括：（1）在生物组织弹性成像方面，研究了多种图像校正方法和应变估计方法，进行了弹性重构和仿体、离体及在体超声弹性成像实验研究；（2）在生物微系统和微血管血流灌注成像方面，制备了三种不同包膜超声造影微泡，研究了纳米包膜厚度检测与估计方法以及不同纳米包膜造影微泡断裂与药物释放机制，并在分子层次上开展了超声与生物组织相互作用机制以及蛋白质药物超声乳化微囊包裹的研究；（3）在阵列式高强聚焦超声治疗与监控成像技术方面，设计制作了新的HIFU换能器，解决了256阵元单焦点和多焦点合成HIFU治疗系统关键技术问题，并在HIFU生物效应与创伤性评价方法、HIFU过程监控成像技术和薄层复合结构与HIFU 换能器界面特性评价等方面的研究取得了初步而重要的进展，具有重要应用前景；（4）在语音听觉系统特别是嗓音康复方面，研究了基于发声系统补偿调节机制的实时多模式嗓音源再生方法和发声生理，建立基于神经、肌肉和空气动力系统的综合补偿调节模型，提出了相应的评价系统。

The cardinal research work is the following: First, analyzed the reason of innovation of to "Biochemistry" curriculum by modern educational technology, the idea and principle of innovation; Second, exploit "Biochemistry" network curriculum fore-six chapter radical content by instruction of educational and psychological theory , subject to Modern Far-distance Education Resource Construction Technical Specification put forth by Far-distance Education Resource Council of Education Department, and by using many kinds of application software; Third, made up module of "Biochemistry" network curriculum, categorize this discipline into preliminary knowledge structure units, made a lot of animated and graphical multimedia stoff and try to reveal new ideas and method, etc, of network curriculum; Finally,"Biochemistry" network curriculum has been used in practical teaching , and it has brought about a good effect and won students high praise

其主要研究的工作为：一、分析了为什么要用现代教育技术革新&生物化学&课程以及革新的观念和原则；二、在具体实践中，以教育心理学理论为指导，以教育部远程教育资源委员会提出的《现代远程教育资源建设技术规范》为依据，结合多种应用软件系统地开发了&生物化学&网络课程前六章的基础内容；三、构建了&生物化学&网络课程的模块结构，并对刻学科的基础知识部份内容作了初步的知识单元结构的化分，加工制作了相当数量的动画类素材及图形类素材，并力求通过&生物化学&网络课程开发的实践揭示网络课程开发中新的理念和方法等；四、将已开发的部份课程内容用于实际教学，效果较好，学生评价较高

Biopreparatics introduce systematically history, achievement, technique and method of scientific and technological development of biological product.

生物制品学是生物制药、生物工程、生物技术专业的专业选修课，系统介绍了生物制品科学技术发展的历史、经济及成果，当代国内外生物技术产品发展的水平和最新成就，以及目前生物制品应用的新技术、新方法。

The macro-organisms, including macro-plants, metazoans and trace fossils, 30 species of 23 genera and 4 macroalgal holdfasts, which are collected from Southeast Zhongqing and Northwest Guizhou, are described herein.

宏体生物广泛地生活于扬子地区伊迪卡拉纪陡山沱期古海洋中，描述了产自渝东南和黔东北伊迪卡拉系陡山沱组的宏体生物(包括宏体植物、后生动物和遗迹化石)共30属，23种，4个不明固着器，其中包括4个新属，5个新种，2个新修正属和1个新修正种。

The macro-organisms lived widely in the Yangtze Sea during the Doushantouian of the Ediacaran. The macro-organisms, including macro-plants, metazoans and trace fossils, 30 species of 23 genera and 4 macroalgal holdfasts, which are collected from Southeast Zhongqing and Northwest Guizhou, are described herein.

宏体生物广泛地生活于扬子地区伊迪卡拉纪陡山沱期古海洋中，描述了产自渝东南和黔东北伊迪卡拉系陡山沱组的宏体生物(包括宏体植物、后生动物和遗迹化石)共30属，23种，4个不明固着器，其中包括4个新属，5个新种，2个新修正属和1个新修正种。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。