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Recent studies indicate that this pathway plays an important role in tumor cells proliferation,blood vessel neogenesis,tumor metastasis and resistance to chemotherapy and radiotherapy.

近年来研究表明,PI3K/AKT信号转导通路在肿瘤细胞恶性增殖、血管新生和转移以及对放化疗的拮抗中起着重要作用。

But no stem cell in grownup in cardiac muscle, the cardiac muscle cant multiply and neogenesis.

另外,还有心脏缺血区的细胞移植,也可促进血管新生

The TZDs improve insulin secretory capacity, decrease beta-cell apoptosis, and reduce islet cell amyloid with maintenance of neogenesis.

噻唑烷二酮类药物提高胰岛素的分泌量,抑制β细胞的碉亡,并通过维持胰岛细胞的新生而降低其淀粉样变。

The vascular endothelial growth factor/vascular endothelial growth factor receptor family in the research of regulating blood vessel neogenesis is the most studied and most important regulator of vascular development.

VEGF/VEGFR系统在调节血管新生中研究最多,也最为重要。

In preclinical studies, oral active DPP-IV inhibitors also promoted beta-cell proliferation, neogenesis, and inhibition of apoptosis in rodents.

临床前研究显示,啮齿类动物经口给予二肽肽激酶IV抑制剂(如sitagliptin与vildagliptin)也引起促进β细胞增生与胰岛新生,抑制β细胞碉亡的作用。

Objective: To investigate the possibility of pathologic scars treated in endostatin , by observing the effects of endothelial cell and neogenesis capillary of pathologic scars treated in endostatin , through establishing models of hyperplastic scar in rabbit ear and injecting Endostatin .

目的:建立兔耳增生性瘢痕的动物模型,并采用内皮抑素局部在体干预,观察其对病理性瘢痕新生毛细血管及血管内皮细胞的影响,以探讨内皮抑素防治病理性瘢痕的可行性。

Results The mutation mouse model was established successfully, and inflammatory reaction such as bacterial infection、inflammatory cell infiltration、proliferation of fibroblast and neogenesis capillaries of neonatal mouse model can be observed with TEM in different stage.

结果 成功建立小鼠模型;在模型小鼠出生后的不同时段中,电镜下小鼠角膜基质内可见有细菌感染、炎症细胞浸润、成纤维细胞及新生毛细血管增生等炎症改变。

The chronic action is stimulating beta-cell proliferation, induction of islet neogenesis, and inhibition of beta-cell apoptosis, thus promoting expansion of beta-cell mass, as observed in rodent diabetes and in cultured beta-cells.

其长期作用是刺激β细胞增生,诱导胰岛新生与抑制β细胞碉亡,因而促进β细胞体积增大,与啮齿类动物糖尿病模型及体外培养的β细胞所观察到的相一致。

In preclinical studies, oral active DPP-IV inhibitors also promoted -cell proliferation, neogenesis, and inhibition of apoptosis in rodents.

临床前研究显示,啮齿类动物经口给予二肽肽激酶IV抑制剂(如sitagliptin与 vildagliptin)也引起促进β细胞增生与胰岛新生,抑制β细胞碉亡的作用。

VEGF and its receptor are highly expressed in most malignant tumors, through para/autoendocrine reaction, promoted endothelial cell division, proliferation and induced vascular neogenesis, directly affecting tumor cell and provoking it to grow.

在绝大多数恶性肿瘤中均呈现VEGF及其受体的高表达,以旁/自分泌作用机制,促进内皮细胞分裂、增殖、诱导血管新生,并可直接作用于肿瘤细胞,刺激肿瘤细胞生长。

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