新月

Objective To investigate the expression and potential role of CD44 and its ligand osteopontin in a rat experimental crescentic nephritis.

目的 探讨CD44及其配体骨调素在实验性新月体肾炎发展过程中的表达和作用。

Methods ANCA was detected and the clinical and pathological features were analyzed in 33 patients with pauci-immune crescentic glomerulonephritis.

对近 10年来诊断为少免疫沉积型新月体肾炎患者进行ANCA检测，并对其中ANCA阴性患者进行临床病理分析。

OPN plays an important role in inducing macrophage infiltration and accumulation in a rat model of crescentic glomerulonephritis.

OPN的高表达是实验性新月体肾炎发病过程中巨噬细胞在肾脏组织局部浸润的重要介导因子，抑制OPN的表达和功能可显著抑制肾脏局部巨噬细胞的聚集及改善肾功能。

Crescentic glomerulonephritis is known as rapidly progressive glomerulonephritis because this disease is very progressive.

新月体性肾小球肾炎之所以被称为快速进行性肾小球肾炎是由于这种疾病的进展非常快。

In the MPO- ANCA positive group, 1 was crescentic glomerulonephritis.

MPO-ANCA阳性2 例，无恶性高血压表现，1 例肾活检示新月体肾炎。

Objective: To analyse clinical appearance, therapy and prognosis of idiopathic IgA nephropathy with crescentic formation and capillary tuft necrosis, to find the clinical characters and discuss the therapy.

目的：通过对IgA肾病患者中伴有新月体形成及毛细血管袢坏死者进行临床表现、治疗及预后指标的分析，了解此类患者的临床特点、探讨治疗方案。

In order to investigate the role of ICAM-1 and VCAM-1 in the pathogenesis of glomerulonephritis, ICAM-1 and VCAM-1 expression were evaluated from both protein and gene level by in vivo and in vitro study, We have conducted (1) immunocytochemical analysis and in situ hybridization to examine the alteration in expression of ICAM-1 and it's relationship with interstitial infiltrating cells and TNFα; A total of 64 renal biopsies were classified in three groups according to the degree of cellular proliferation and infiltration in glomerulus;(2) indirect immunofluoresence and immunoblotting. methods to detect the VCAM-1 level both in renal tissue and in serum from the patients of lupus nephritis (17cases) and crescentic nephritis (4 cases);(3) Cell ELISA and northern blot technique to study the effects of TNFα and IL-1β on ICAM-1 and VCAM-1 surface expression and gene expression by cultured human mesangial cells .

为了探讨ICAM-1和VCAM-1在肾小球疾病中的作用，本文从蛋白质和基因两个水平，整体（研究ICAM-1时根据肾小球内细胞增生和浸润程度，将64例病人分为A.B.C三组）和细胞培养两个方面，做了如下工作，（1）利用免疫细胞化学和原位杂交技术观察了ICAM-1在64例肾小球疾病患者中的表达及其与间质浸润细胞、TNFα之间的关系；（2）利用间接免疫荧光和膜免疫印迹方法检测了VCAM-1在17例狼疮肾炎和4例新月体肾炎病人肾组织及血清中的表达；（3）利用细胞ELISA和Northern杂交技术研究了IL-1β或TNFα对体外培养的人肾小球系膜细胞ICAM-1和／或VCAM-1表面表达及mRNA表达的调节作用。

Objective: To analyse clinical appearance,therapy and prognosis of idiopathic IgA nephropathy with crescentic formation and capillary tuft necrosis,to find the clinical characters and discuss the therapy.

作者：徐艺作者单位：广东省深圳市第二人民医院肾内科，广东深圳 518035 目的：通过对IgA肾病患者中伴有新月体形成及毛细血管袢坏死者进行临床表现、治疗及预后指标的分析，了解此类患者的临床特点、探讨治疗方案。

Classically, c-ANCA is associated with Wegener's granulomatosis; p-ANCA is associated with microscopic polyangiitis and focal necrotising and crescentic glomerulonephritis .

古典和 c -抗体与韦格纳肉芽肿病；型ANCA 与显微镜下多血管炎和协调坏死和新月体肾炎。

Analyzing the clinical and pathological information of 32 patients who were diagnosed by renal biopsy as idiopathic IgA nephropathy with crescentic formation and/or capillary tuft necrosis, and compare with those idiopathic IgA nephropathy which have no crescents and necrosis.

对32例肾活检证实原发性IgA必肾病伴有新月体形成和／或血管袢坏死者的临床及病理资料进行分析，并与无此类病变的IgA肾病患者进行对比。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。