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Antigene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis Roberto Tonelli,Stefania Purgato,Consuelo Camerin,Raffaele Fronza,Fabrizio Bologna,Simone Alboresi,Monica Franzoni,Roberto Corradini,Stefano Sforza,Andrea Faccini,Jason M. Shohet,Rosangela Marchelli,and Andrea Pession Department of Pediatrics, University of Bologna,Sant'Orsola-Malpighi Hospital, Bologna, Italy; Department of Organic and Industrial Chemistry, University of Parma, Parma,Italy; and 3Center for Cell and Gene Therapy, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas Abstract We developed an antigene peptide nucleic acid for selective inhibition of MYCN transcription in neuroblastoma cells, targeted against a unique sequence in the antisense DNA strand of exon 2 of MYCN and linked at its NH2 terminus to a nuclear localization signal peptide.

抗原肽核酸抑制MYCN具体表达的神经母细胞瘤细胞,导致细胞生长的抑制和凋亡罗伯托利,斯特凡Purgato ,苏埃洛卡默琳,拉菲尔Fronza ,梅奥尼博洛尼亚,西蒙娜Alboresi ,莫妮卡弗兰索尼,罗伯托Corradini ,斯特凡诺斯福尔扎,安德烈Faccini ,杰森先生Shohet , Rosangela Marchelli ,和安德烈Pession儿科,博洛尼亚大学,圣' Orsola -马尔皮基医院,博洛尼亚,意大利;有机部和工业大学化学帕尔马,帕尔马,意大利和3Center的细胞和基因治疗,德州儿童癌症中心, Baylor医学院,得克萨斯州休斯敦摘要我们开发了一种抗原肽核酸的选择性抑制神经母细胞瘤MYCN转录细胞,针对一个独特的序列反义DNA链的第2外显子,并与在MYCN 其氨基端为核定位信号肽。

Harmodius and Aristogiton, Brutus, Chereas, Stephanus, Cromwell, Charlotte Corday, Sand, have all had their moment of agony when it was too late.

阿尔莫迪乌斯和阿利斯托吉通、布鲁图斯①、谢列阿②、史特方纽斯、克伦威尔③、夏绿蒂·科尔黛④、桑得⑤,他们事后都曾有过苦闷的时刻。

At present the order has a cardinal, Sebastiano Martinelli (formerly Apostolic delegate for the United States), several bishops--Guglielmo Pifferi; Stephen Reville, Bishop of Sandhurst in Australia; Arsenio Campo y Monasterio, Bishop of Nueva Cáceres in the Philippine Islands; Giovanni Camilleri, Bishop of Gozzo; José López de Mendoza y Garcia, Bishop of Pampeluna, Spain; Giuseppe Capecci, Bishop of Alessandria in Italy; Francisco Xavier Valdés y Noriega, Bishop of Salamanca; William A. Jones, Bishop of Porto Rico; the Vicars Luis Perez of Northern Hu-nan and Dominic Murray, Cooktown, Australia; the Prefect Apostolic (Paulino Díaz Alonso) of San León de Amazonas--and, finally, two mitred abbots.

目前,为了有一个基数,塞巴斯马蒂内利,一些主教-古列尔莫P ifferi ;斯蒂芬雷维尔,桑赫斯特主教在澳大利亚;阿塞尼奥坎普y修道院,主教在新卡塞雷斯菲律宾群岛;乔瓦尼卡米莱主教Gozzo ;何塞洛佩斯德门多萨y加西亚,主教Pampeluna ,西班牙;朱塞佩Capecci ,主教在意大利亚历山德里亚;弗朗西斯泽维尔巴尔德斯y诺列加,萨拉曼卡主教;威廉A琼斯,主教波尔图队的路易斯佩雷斯Vicars北胡楠和多米尼克墨累,库克敦,澳大利亚;使徒的省长的圣莱昂的亚马孙-最后,两个m itreda bbots。

Her first film, Ratcatcher, set during the binmen strikes of 70s Glasgow, was the anti-Billy Elliot; her second, adapted from Alan Warner's novel More about Morvern Callar, confirmed her promise.

她的第一部电影,捕鼠者,70年代期间格拉斯哥binmen罢工设置,是反比利埃利奥特,她的第二个,从格林斯潘时代华纳的小说对莫文卡利亚尔更多信息,适应证实了她的承诺。

Christ Church has a fascinating history and many distinguished people have studied here including John Taverner, Philip Sidney, John Locke, Robert Hooke, John Wesley, Robert Peel, William Gladstone, Frederick Lindemann, William Walton, WH Auden, Hugh Trevor Roper, Jan Morris, David Dimbleby, Rowan Williams, Richard Curtis and Howard Goodall.

基督教堂有一个迷人的历史和许多杰出的人在这里学习过,包括约翰Taverner ,菲利普西德尼,洛克,罗伯特虎克,约翰卫斯理,罗伯特皮尔,威廉格拉德斯通,弗雷德里克林德曼,威廉顿,武汉奥登,休特雷弗罗佩尔,一月莫里斯大卫丁布尔比,威廉斯,理查德柯蒂斯和霍华德古道。

Reinhard Mohn was born in 1921 in Gütersloh, in eastern Westphalia, the fifth of six children of strict Protestant parents.

赖因哈德?莫恩于1921年出生在威斯特伐利亚东部的居特斯洛,在6个孩子中排行第5,父母是行为严谨的新教徒。

Gurr (1981); A Bibliography of Katherine Mansfield by BJ Kirkpatrick (1990); Katherine Mansfield by Jane Phillimore (1990); Katherine Mansfield: A Study of Her Shorter Fiction by JF Kobler (1990); Critical Essays on Katherine Mansfield, ed.

古尔(1981年);由北京帕特里克书目凯瑟琳曼斯菲尔德(1990年);凯瑟琳由Jane菲利莫尔(1990)曼斯菲尔德,凯瑟琳曼斯菲尔德:她的短由JF凯柏勒(1990年)小说研究;在曼斯菲尔德批评文章,编。

World Sites: Sarajevo's Academy of Fine Arts, New Zealand's Porirua City's Pataka Museum, the Cultural Center of the Philippines, NYC's Mercer Park, Spain's Ethnological Museum, Toronto's Wallace Emerson Park, Taipei's Kuandu Museum of Fine Arts, Fine Art Museum of Ho Chi Minh City, Istanbul's Artemis Art Center, Berlin's Bar of Modern Art, etc.

「磁砖计画」终点:世界22个世界据点:沙拉杰佛艺术学院、纽西兰波利洛市、巴塔卡博物馆、菲利宾文化中心、纽约市马瑟公园、西班牙民族博物馆、多伦多华勒士、伊莫森公园、台北关渡美术馆、胡志明市美术馆、伊斯坦堡阿特米斯中心、柏林现代美术酒吧。。。。。。

Journal of Agricultural and Food Chemistry Effect of Different Cooking Methods on Color, Phytochemical Concentration, and Antioxidant Capacity of Raw and Frozen Brassica Vegetables Abstract Full Text HTML Hi-Res PDF[965 KB] PDF w/ Links[892 KB] Nicoletta Pellegrini*, Emma Chiavaro, Claudio Gardana§, Teresa Mazzeo, Daniele Contino§, Monica Gallo#, Patrizia Riso§, Vincenzo Fogliano# and Marisa Porrini§ Department of Public Health, University of Parma, via Volturno 39, 43125 Parma, Italy Department of Industrial Engineering, University of Parma, viale GP Usberti 181/A, 43124 Parma, Italy § Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche, sezione Nutrizione Umana Universit degli Studi di Milano, via Celoria 2, 20133 Milan, Italy # Department of Food Science, University of Napoli "Federico II", Parco Gussone, 80055 Portici, Napoli, Italy J.

农业化学与食品化学杂志对不同烹饪方法对颜色,植物化学浓度,及抗氧化能力的原料和冷冻甘蓝菜抽象全文网页高清晰度PDF格式[965 KB的] PDF格式瓦特/友情链接[892 KB的] 妮可佩莱格里尼*,艾玛基亚瓦罗,克劳迪奥加尔达纳§,特雷莎Mazzeo,丹尼尔蒂诺§,莫妮卡加洛#,帕特里齐亚公共卫生部,帕尔马大学,通过沃尔彻诺39,43125帕尔马,意大利工业工程,帕尔马是:Viale大奖赛乌斯贝蒂大学181 /年,43124帕尔马,意大利§ Dipartimento迪有关科学é Tecnologie Alimentari é Microbiologiche,sezione Nutrizione乌马纳大学德利阿布鲁史都迪迪米兰,通过西洛里亚2,20133米兰,意大利#食品科学系,那不勒斯&费德里科二&大学,Parco公司古索,80055波尔蒂奇,那不勒斯,意大利 j的农耕。

Other rallies will take place at Blytheswood Square, Glasgow; Bedford Square, Exeter; Princes Street, Edinburgh; Bristol city centre; Bold Street, Liverpool; Norwich Forum; Portsmouth's Guildhall Square; Queen Victoria Square, Hull; Tunbridge Wells town centre; Leeds Art Gallery; All Saints Park, Manchester; Grey's Monument, Newcastle; Castle Square, Swansea; St Sampson's Square, York; Morrisons, Caernarfon; Bradford city centre; and Sheffield town hall.

其他集会将在Blytheswood广场,格拉斯哥;贝德福德广场,埃克塞特;王子街,爱丁堡,布里斯托尔城中心;大胆街,利物浦;诺威奇论坛;朴次茅斯的市政厅广场,维多利亚女王广场,赫尔;滕布里奇韦尔斯镇中心;利兹美术馆;诸圣公园,曼彻斯特;灰色的纪念碑,纽卡斯尔;城堡广场,斯旺西;圣桑普森广场,纽约;莫里森,卡纳芬;布拉德福德市中心;和谢菲尔德大会堂。

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推荐网络例句

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。

There is no differences of cell proliferation vitality between labeled and unlabeled NSCs.

双标记神经干细胞的增殖、分化活力与未标记神经干细胞相比无改变。