断裂点

It is revealed that the aberration of sex chromosome causes the most serious spermatogenesis failure and some breakpoints of autosome may also affect spermatogenesis.

由此可见，性染色体数目和结构异常是精子发生障碍的主要原因，其次常染色体的某些断裂点也可能影响精子发生。

A simulated bridge deck is tested for durability and strength to determine its breaking point .

这个模拟桥面用来测试其耐力与强度，以确定断裂点。

Horizontal lines denote size and position of patients exon-deleted; broken lines denote imprecisely defined breakpoints

横线表示患者所缺失外显子的范围及位置；虚线表示未能确定的断裂点

To solve the model, the theory of optimization is applied and a linear objective function is proposed.

根据优化理论建立了线性目标函数并对建立起来的腐蚀、断裂点判断数学模型进行了求解。

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

RT-PCR detection of SYT-SSX mRNA can be used in formalin-fixed, paraffin-embedded tissues as a sensitive and specific technique in the diagnosis and differential diagnosis of synovial sarcoma. 2. The SYT-SSX fusion type is related to histological type and cell proliferative activity of synovial sarcoma. 3. Some characteristic sequence motifs flank genomic breakpoints of chromosomal translocation of synovial sarcoma, including Alu sequences, Translin recognition sequences, topoisomerase Ⅱ recognition sites and palindromic sequences, which may be associated with chromosomal translocation of synovial sarcoma.

1、RT-PCR技术检测SYT-SSX mRNA表达可用于福尔马林固定、石蜡包埋组织，敏感性和特异性高，可用于滑膜肉瘤诊断和鉴别诊断。2、SYT-SSX融合基因类型与滑膜肉瘤组织学分型及细胞增殖活性相关。3、滑膜肉瘤染色体易位断裂点旁存在一些特征性序列，包括Alu序列、易位素识别序列、拓扑异构酶Ⅱ识别位点、回文序列等，可能与其染色体易位发生机制有关。

There were some characteristic sequences flanking the genomic breakpoints of SYT, SSX1 and SSX2. These sequences included Alu sequences, Translin recognition sequences, topoisomerase Ⅱ recognition sites and palindromic sequences. These sequences are speculative to be associated with chromosomal translocation of synovial sarcoma.

在SYT，SSX1和SSX2基因组断裂点旁存在一些特征性序列，包括Alu序列、易位素识别序列、拓扑异构酶Ⅱ识别位点、回文序列等，可能与滑膜肉瘤染色体易位有关。

The Breaking Point Theory is widely used in delimiting urban abstracted regions and dividing up urban economic regions.

P 。D 。Converse提出的城市断裂点理论被广泛用来确定城市的空间影响范围和城市经济区的划分。

Then he jumped again and again and the boat was going fast although line was still racing out and the old man was raising the strain to breaking point and raising it to breaking point again and again.

接着又一次一次地跳起来，虽然线绳仍不断地往前冲，船却移动得好快，老人拼命地拉紧线绳直到濒临断裂点，他继续增强拉力，线绳几度近乎断裂。

It can detect he break-point.move along the phase conductor excluding the head,it is a break point if there is no display there.

用它可以检测断裂点，除去头部，沿着相导线移动验电器，如果没有显示，则那里就是断裂点。

Singer Leona Lewis and former Led Zeppelin guitarist Jimmy Page emerged as the bus transformed into a grass-covered carnival float, and the pair combined for a rendition of "Whole Lotta Love".

歌手leona刘易斯和前率领的飞艇的吉他手吉米页出现巴士转化为基层所涵盖的嘉年华花车，和一双合并为一移交&整个lotta爱&。

This is Kate, and that's Erin.

这是凯特，那个是爱朗。