斑蝥

Methods MTT assay was used to determine the proliferation inhibition by cantharidin to A549 cell. FACS can were applied to detect the change of cell cycle.

采用MTT法检测斑蝥素对A549细胞增殖的抑制作用；流式细胞仪分析A549细胞周期及斑蝥素对细胞周期的影响。

Objective Studying the apoptotic cytology of K562 cells induced by cantharidin and norcantharidin.

目的 研究抗癌药物斑蝥素及去甲斑蝥素诱导人红白血病K562细胞凋亡的细胞学变化特点。

However, it is very toxic. Nocantharidin, a derivative of cantharidin first synthesized in China, is a new anti-tumor drug with strong anti-tumor activities and increases the number of while blood cells.

去甲基斑蝥素(noncantharidion， NCTD)为斑蝥素的衍生物，是我国首先合成的具有较强抗肿瘤活性和独特升高白细胞作用的新型抗肿瘤药物。

According to results of cantharidin structure-activity relationships, a series of cantharidin derivatives for the first time were designed, synthesized and characterized by IR, NMR and elemental analysis.

用IR、〓H NMR初步证实了斑蝥素衍生物和DCC生成稳定中间体是使含有芳香羧酸的斑蝥素衍生物与氨基葡萄糖及其衍生物不能进行反应的主要因素。

The achievements of this paper are as follows:(1) A series of cantharidin derivatives, saccharide-cantharidin derivatives compounds, saccharide-5-fluorouracil derivatives compounds and 5-fluorouracil derivatives organotin complexes have been firstly synthesized.

本论文的创新点在于：首次合成了一系列斑蝥素衍生物，斑蝥素衍生物-糖化合物，5-氟尿嘧啶衍生物-糖化合物和5-氟尿嘧啶衍生物-有机锡配合物。

Physical stability of liposomes plays the critical roles in various stages of the applications and development of liposomes. In this study, we applied low molecular weight chitosan to modify the liposomes surface, and investigated the physical stability of liposomes, Moreover, we encapsulated cantharidin to study the effects of chitosan which cause drug leakage.

微脂粒稳定性的研究在其应用发展上占有举足轻重的影响，因此本研究利用低分子量水溶性几丁聚醣来修饰微脂粒表面，观测几丁聚醣对微脂粒物理稳定性的影响，同时也一并探讨包覆抗癌药物斑蝥素，几丁聚醣对微脂粒包覆斑蝥素的渗漏情形。

The study on soluble protein after eclosion when cantharidin synthesis is active in Mylabris calida Palla would help to clarify the synthesis mechanism of cantharidin and involved enzymes of the synthesis.

研究斑蝥素大量合成期的芫菁体内可溶性蛋白，有助于阐明斑蝥素合成相关酶蛋白的种类和合成机理。

Besides, the series of synthetic compounds were tested for their capability to suppress growth of human hepatocellular carcinoma cell line Hep 3B and Hep G2, and myeloid leukemia cell line HL-60. The results showed compound 20, N-(2-amino- 3-nitrophenyl)cantharidinimide, exhibited more potent than others, but it was still less effective than cantharidin.

此外也利用斑蝥胺的衍生物对人类肝癌细胞Hep 3B和Hep G2，以及血癌细胞HL-60的细胞毒性进行测试，结果显示化合物20 [N-(2-amino-3-nitrophenyl)cantharidinimide]有较好的抑制作用，但是效果仍未比斑蝥素好。

Objective:To investigate the effect of cantharides infections on LoVo cell.

复方斑蝥注射液是从斑蝥、刺五加、黄芪、人参等中药中经现代独有的高科技工艺提取的新型多靶点抗肿瘤药，具有抗肿瘤和免疫调整双重作用，在临床上得到了广泛的应用。

Part II: The structural modification of norcantharidin and the discovery and applications of NCS-DMSO combinatorial system: A series of derivatives of 5,6-dehydronorcantharidin was transferred into their corresponding 5,6-epoxynorcantharidin derivatives with Oxone, and finally 14 new compounds have been synthesized; and we also discover the novel combinatorial system NCS-DMSO to make N-aromatic substituted norcantharidin amic acids to their corresponding imides in high yields.

利用十分廉价的Oxone为氧化剂，成功的得到了14个5，6-环氧去甲斑蝥素系列衍生物；同时我们意外地发现了NCS-DMSO组合体系可以使去氢去甲斑蝥素酰胺类化合物实现分子内脱水而生成亚胺类化合物，首次发现和运用该全新的组合体系实现了该类反应。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。