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Prenatal EGF can improve pulmonary hypoplasia in the Nitrofen-induced CDH rat model, which was manifested as increased Lw/Bw and more mature histological and morphometrical pulmonary appearances. Moreover, EGF can promote type Ⅱ pneumocytes differentiation and increase their amounts, thus increase the production of surfactant.

EGF对大鼠先天性膈疝模型肺发育不良具有明显的改善作用,不仅可以促进肺组织生长,表现在肺重量/体重增加,肺组织形态得到明显改善,而且对Ⅱ型细胞有明显的促分化作用,Ⅱ型细胞密度增加,功能增强;而且随着EGF剂量的增加作用加强,当剂量为150ug/只(600ug/kg)时,作用较为明显。

The four methods all can improve limbs function, activaties daily life, myodynamia, but no significant difference among four methods.

而针刺痉挛侧穴位强、弱刺激治疗前后临床痉挛指数、Ashworth评分未见明显改善,强、弱刺激之间也未见明显差别。4种不同方法对痉挛性偏瘫的肢体活动能力、日常生活能力、肌力均能起到改善作用,但是4种方法之间肢体活动能力、日常生活能力、肌力比较未见明显差别。

"Tuina Manipulation combined with Exercise Therapy" treating the lumbar disc herniation cases has a significant long residual effect. Analying the anatomy, physiological characteristics, mechanics analysis of the waist and LDH's modern research, its mechanism may adjust to lumbar compliance; ease cramps; change the relative positions of disc and nerve roots, reduce or lift the oppression; correct facet dislocation; release adhesions, improve circulation and promote absorption and repair of the inflammation and edema; analgesic pain threshold or enhance the organization; improve the waist myodynamia; reconstruct the balance of the waist and so on.

结合腰部椎体、肌肉及韧带等组织的解剖、生理特点、力学分析和腰椎间盘突出症的现代研究分析,其机制可能是调整腰椎顺应性,缓解痉挛;改变突出髓核与神经根的相对位置,减轻或解除压迫;纠正小关节错位及滑膜崁顿;松解粘连,改善循环,促进炎症、水肿的吸收和损伤修复;镇痛与提高组织痛阈;改善腰部肌力;促进人体生物力学结构重构;恢复腰椎及其周围力学平衡等几个方面。

The recent experimental studies have shown that bone marrow stem cells are capable of regenerating infracted myocardium and inducing myogenesis and angiogenesis, which improving myocardial perfusion and cardiac function.

目前的研究表明,移植的骨髓干细胞可以分化为心肌细胞,使心肌梗死瘢痕区血管和心肌再生,改善缺血心肌血供,改善心脏功能。

2Myocardial ultrastructure was normal in the control group,myoneme arranged disordered,the structure of typical sarcomere disappeared, mitochondrium intumesced,interstitial substance fiber hyperplasy,capillary vessel endothelial cell swelled in DG group.Myocardial ultrastructure improved slightly in rats of SM and LM groups. 3NF-κB p65 and COX-2 had a small quantity to present in the myocardium tissue of control group,while the quantity increased obviously in the diabetic group.The level of it in the group of treatment was significant lower than that in the diabetic group.There was significant difference between the two groups. Conclusion Metformin can protect against the heart injury in diabetic.

结果 1与对照组比较,DG组体重明显减轻,血糖、心脏质量指数、INS、TG、T-CH及FFA明显升高(P<0.01);应用 MT治疗后体重无明显增加,INS有所下降,心脏质量指数、血糖、TG及FFA明显降低(P<0.01);DG组心肌组织MDA明显升高,SOD明显降低(P<0.01),MT治疗后上述指标明显改善;2超微结构观察单纯糖尿病组肌丝结构明显紊乱,典型肌小节结构消失,线粒体肿胀、间质纤维增生,微血管内皮细胞肿胀等表现,而SM及LM组可见组织结构有所改善;3对照组心肌NF-κB p65及COX-2只有少量表达,单纯糖尿病组表达量明显增多(P<0.01),MT治疗后表达量明显减少(P<0.01)。

The treated with glucocorticoid and combined therapy such as anti platelet aggregation, scavenging free radicals, reducing intracranial pressure, improving microcirculation and promoting neuronic metabolism, the condition get better.

经糖皮质激素以及抗血小板聚集、清除自由基、降低颅内压、改善微循环等综合治疗,病情明显改善

After 6-12 months, the therapeutic effect of albendazole was estimated in subcutaneous-muscular cases by the number of subcutaneous nodules, the activity and the morphological change of larvae in cerebral cases by the neuropsychic symptoms, CSF changes, CT fi...

结果皮下肌肉型患者的治愈率为64%,显效率为25.6%,改善率为10.4%:脑型患者治愈率为40.6%,显效率为44%,改善率为15.4%。不良反应较少,较轻,未发现无效病例及因副反应而中止疗程者。

PPAR γ agonist displayed obvious renoprotective action,the mechanism was complicated, it could improve the metabolism of glucose ang lipid, depress blood preasure, protect small vessels endothelium,improve the system activity of blood clotting and fibronolysis, antiinflammation, otherwise the action was more obvious with the time passed, at the early stage the effective was better,so encourage the patients to take the medicine earily; when the patients with the mediate reanl function failure, Avandia did not display significantly renoprotective action, side reaction had no difference compared to the control group,was not necessary to regulate the dose of Avandia.But because of the sample size was small, we needed a biger sample to confirm the results. We confirmed that Prol2Ala had no difference in control case,diabetic nephropathy group and diabete group,In diabetic group and diabetic nephropathy group, Ala carriers compared to noncarrier all kinds of biochemical indicators were not different,Prol2Ala did not have association with diabete and diabetic nephropathy. But because of the sample size was small, weneeded a biger sample to confirm the results.

PPARγ激动剂对糖尿病肾病具有明显的保护作用,保护作用的机制是多方面的,除了改善糖脂代谢,降低血压外,还具有保护小血管内皮,改善凝血和纤溶系统活性,抗炎症等多方面的作用,且作用随着用药时间的延长而日趋明显,在疾病的早期应用效果更佳,故提倡早期用药;对伴有慢性肾功不全的患者,罗格列酮对肾脏靶器官的保护作用显现的并不明显,但副作用与对照组无明显差异,不用根据肾功情况调整用药,但由于样本量较小,上述结论尚需大样本进行进一步证实;本实验研究得出Prol2Ala变异在健康对照组、糖尿病组及糖尿病肾病组均无显著差异,糖尿病组及糖尿病肾病组临床各生化指标与Prol2Ala变异亦无相关性,Prol2Ala与糖尿病及糖尿病肾病不相关。

Results: Among the 1699 subjects included in the efficacy analysis, NXY-059 significantly improved the overall distribution of scores on the modified Rankin scale, as compared with placebo (P = 0.038 by the Cochran-Mantel-Haenszel test). The common odds ratio for improvement across all categories of the scale was 1.20 (95 percent confidence interval, 1.01 to 1.42). Mortality and rates of serious and nonserious adverse events were each similar in the two groups.

结果:在1699例可进行有效分析的患者中,NXY-059较安慰剂显著改善了患者改良Rankin量表评分的总体分布(CMH检验P=0.038),量表所有项目的评分都得到改善的共同OR值为1.20(95%CI1.01~1.42),两组患者的死亡率及严重和不严重副作用的发生率均相似。

In the third part, Ginaton and FK506 were used to improve the reperfusion of the xenograft model. When the rats were pretreated with Ginaton 30min before the transplantation, the PVBF of the xenografts at time 0, 15, 30, 45 and 60min after transplantation were 0.406±0.020, 0.357±0.025, 0.308±0.013, 0.249±0.019 and 0.205 ±0.014kHz respectively, significantly higher than those of the nontreatment rats.

为了改善豚鼠至大鼠肝移植后移植肝的微循环再灌注障碍,在接下来的第三部分中,分别进行了微循环改善剂金纳多、免疫抑制剂FK506和两者联合应用的作用研究。

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