改变

Results Analysis of the expression of proteins of JAK2 in leukemic blasts, there was no detectable constitutive expression of phosphorylated JAK2 in all the AML samples analyzed; Furthermore, we could detect a constitutive activation of STAT 3 by immunoprecipitation of the targeted protein in primary leukemic blasts from 3 of 11 AML patients without any cytokine treatment; Pretreatment clinical characteristics, and treatment regimens did not differ significantly between patients with and without constitutive STAT3 activity, there was not significant relation between the constitutive activation of STAT3 and the FAB subvariety and chromosome karyotype; However, the 3 patients with constitutive STAT3 activity seemed to have adverse treatment outcome, one did not show remission, the other two patients relapsed shortly after remission; Consistent with the above-mentioned result, leukemic blasts from the 3 samples with constitutive expression of STAT3 showed higher percentage of spontaneous apoptosis and S-phase cells.

在实验研究基础上，本研究进一步运用免疫沉淀和Western Blot印迹方法，检测AML患者原代细胞JAK2和STAT3活化情况，并分析了STAT3活化与AML患者预后有关指标改变的关系。结果我们的初步研究发现，11例AML患者中，有3例呈现STAT3组成型活化（STAT3阳性，下同），无一例呈JAK2组成型活化。上述3例STAT3组成型活化与FAB分型和染色体核型改变未见明显相关性；在此3例患者中，1例未取得缓解，另外2例虽然取得短暂缓解，但均在二个月内复发。上述3例STAT3阳性AML患者S期白血病细胞百分率数值较组高，而凋亡率数值较低。

Experimental process, to determine the most suitable reaction temperature, the temperature in the most appropriate amount of catalyst to change and to identify the most suitable amount of catalyst, in the amount of catalyst and temperature conditions to determine the types of changes in solvent, and to compare the differences reflect under the conditions of the conversion rate of dimethyl sulfoxide.

实验过程中，先确定最适合的反应温度，在最合适的温度下改变催化剂的用量并确定最合适的催化剂用量，在催化剂的用量和温度确定的条件下改变溶剂的种类，并比较在不同反映条件下的二甲基亚砜的转化率。

With the change of the economic foundation, the superstructure has to be transformed too.

随着经济基础的改变，上层建筑也必须改变。

The necessity that he shall conform, that he shall cohere, is not one-sided; what happens when a new work of art is created is somethingthat happens simultaneously to all the works of art which preceded it. The existing monuments form an ideal order among themselves,which is modified by the introduction of the new work of art among them. The existing order is complete before the new work arrives; for order to persist after the supervention of novelty, the whole existing order must be, if ever so slightly,altered; and so the relations, proportions, values of each work of art toward the whole are readjusted; and this is conformity between the old and the new.

他之必须适应，必须符合，并不是单方面的产生一件新艺术作品，成为一个事件，以前的全部艺术作品就同时遭逢了一个新事物现存的艺术经典本身就构成一个理想的秩序，这个秩序出于新的作品被介绍进来而发生变化这个已成的秩序在新作品出现以前本是完整的，加入新花样以后要继续保持完整，整个的秩序就必须改变一下，即使改变得很小；因此每件艺术作品对于整体的关系、比例和价值就重新调整了；这就是新与旧的适应。

The necessity that he shall conform, that he shall cohere, is not one-sided; what happens when a new work of art is created is something that happens simultaneously to all the works of art which preceded it. The existing monuments form an ideal order among themselves, which is modified by the introduction of the new work of art among them. The existing order is complete before the new work arrives; for order to persist after the supervention of novelty, the whole existing order must be, if ever so slightly, altered; and so the relations, proportions, values of each work of art toward the whole are readjusted; and this is conformity between the old and the new.

他之必须适应，必须符合，并不是单方面的产生一件新艺术作品，成为一个事件，以前的全部艺术作品就同时遭逢了一个新事物现存的艺术经典本身就构成一个理想的秩序，这个秩序出于新的作品被介绍进来而发生变化这个已成的秩序在新作品出现以前本是完整的，加入新花样以后要继续保持完整，整个的秩序就必须改变一下，即使改变得很小；因此每件艺术作品对于整体的关系、比例和价值就重新调整了；这就是新与旧的适应。

The former is a tooth surface color change, which is the formation of teeth within the entire tooth color change.

前者是牙齿表面出现的颜色改变，后者是牙齿内部形成的整个牙体的颜色改变。

The former is a tooth surface color changes, which is the formation of teeth within the entire tooth color change.

前者是牙齿表面出现的颜色改变，后者是牙齿内部形成的整个牙体的颜色改变。

If you can ' t change your surroundings, you can change yourself.

你改变不了环境，但是你可以改变自己。

If you can't change your surroundings,you can change yourself

你改变不了环境，但是可以改变自己。

Objective Analyze the X-ray changes of symphysis pubica osteochondrosis.Methods Observe the substantia,the broad of symphysis pubica,and the prognosis of it.

目的 总结耻骨联合骨软骨病的X线改变方法观察耻骨联合间隙、骨质、预后的X线改变。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。