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The outcomemeasures used to assess lung injury included: the change inweight gain and ultrafiltration coefficient, the frequency ofvascular failure, the histological lesions and the concentrationof tumor necrosis factor- and malondialdehyde in the bronchoalveolarlavage fluid.

评估肺损伤程度的项目包括:重量增加和超滤系数的改变,血管功能衰竭的频率,组织学病变及肿瘤坏死因子的浓度和支气管肺泡灌洗液中的丙二醛的量。

Methods:Using Japan Shimadzu 1250Ma CCD DSA X machine,4F RH or 4F YASHIRO catheter and 3F SP microcatheter were employed in superselective chemoembolization for feeding artery of lung cancer and the metastases tumor with rich blood feeding in lung with lipiodol and 2~3 species chemodrug.The period of repetitive treatment was 4~6weeks.After treatment,the change of the symptoms,images of neoplasm and the survival rates were observed.

材料与方法:在日本岛津1250MA CCD数字减影X光机的引导下,使用4F RH或4F YASHIRO超滑导管及3F超滑微导管实施超选择性肿瘤滋养动脉插管,以超液态碘油及2~3种化疗药物对临床及病理证实的原发性支气管肺癌、肺富血供性转移瘤灶实施完全性化疗栓塞,重复治疗间隔时间4~6周,术后随访观察临床症状的变化、肿瘤的影像学改变、生存率等。

METHODS Low-dose Peth 0.01, 0.1 and 1 mgkg^(-1) were given iv 10 min before guinea pigs inhaled 75% cigarette smoke 60 mL. Then, the changes in airway resistance R(subscript aw, dynamic lung compliance C(subscript dyn and vascular permeability in airway tissues were observed. The total leukocyte and the differential leukocyte in bronchoalveolar lavage fluid and nitric oxid e content in BALF were investigated after guinea pigs given iv Peth 0.1 mgkg^(-1) 10 min before cigarette smoke inhalation and consecutively inhaled 360 mL smoke in 2 h.

观察Peth 0.01,0.1和1mgkg^(-1)对豚鼠自主吸入75%香烟烟雾(含25% O2)60mL后,气道阻力和肺动态顺应性变化的影响及气道组织血管通透性变化的影响;观察Peth 0.1mgkg^(-1)对豚鼠2h内分6次吸入(共360mL)75%浓度的香烟烟雾后,支气管肺泡灌洗液中白细胞总数和分类计数改变的影响,测定BALF中一氧化氮含量。

Suggested theories for the etiology of these lesions include congenital malformation of a displaced bronchial anlage, hyperplasia of normal lung tissues, cartilaginous benign neoplasia, and responses to inflammation.

本病的发病机制学说包括支气管原始细胞错位导致的先天性异常,正常肺组织的增生,良性肿瘤的软骨化,以及炎性反应。

DESIGN: In a population based birth cohort, the Avon Longitudinal Study of Parents and Children, we related dietary patterns in pregnancy, previously identified using principal components analysis ('health conscious', 'traditional', 'processed', 'vegetarian', and 'confectionery'), to: early wheezing phenotypes and eczema; wheezing, hayfever, eczema, doctor-diagnosed asthma, atopy and total IgE at 7 years; lung function and bronchial responsiveness at 8-9 years.

试验设计:在一项基于出生的队列研究(Avon双亲与儿童的纵向研究, ALSPAC)中,通过主成分分析(健康意识;传统饮食;食物加工;素食;糕点),研究怀孕母亲的膳食结构与喘息早期表型和湿疹;喘息、枯草热、湿疹、医生诊断的哮喘、7岁时特应性和总IgE水平;8-9岁时的肺功能和支气管反应性之间的关系。

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