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The bronchiole region and the alveolar well fibrosis caused the complaisance of the lung degraded the volume of lung decrease and the dysfunction ventilation.

由于细支气管领域和肺泡壁纤维化使肺的顺应性降低导致肺容量减少和限制性通气障碍。

OBJECTIVE: To study the effects of prolonged 75% oxygen exposure on the expression of vascular endothelial growth factor and its receptors (VEGFR1 and VEGFR2) in the neonatal rat lungs and to elucidate the effects of prolonged exposure of high concentration of oxygen on lung vascular development and its relationship with bronchopulmonary dysplasia.

目的:研究持续吸入75%氧对新生大鼠肺血管内皮生长因子(vascular endothelial growth factor,VEGF)及其受体(VEGFR1和VEGFR2)表达的影响,探讨较高浓度吸氧对肺血管发育的影响及与支气管肺发育不良(bronchopulmonary dysplasia,BPD)的关系。

Objective Oxygen toxicity plays a major role in the pathogenesis of bronchopulmonary dysplasiain neonates requiring ventilation.

支气管肺发育不良(bronchopulmonary dysplasia, BPD)是一种因长期用氧,氧毒性使肺组织纤维化及肺萎陷的病变[1]。

In this report, we analyzed the cellular and noncellular findings of bronchoalveolar lavage fluid in 18 cases with IPF, 12 patients with Sar and 9 healthy volunteers as conirols, using immunohistochemicat staining, we also have estimted collagen typeⅠ and type Ⅲ semiquantitatively in transbronchial lung biopsy specimens from 25 patients with IPF and 10 normal lung tissue. The aim of this investigation is to select the criteria for evaluating the disease actiity.

本文对18例IPF、12例Sar和9例正常对照者的支气管肺泡灌洗液中细胞成份和非细胞成份进行了检测和分析,同时对10例正常肺和25例IPF患者经支气管肺活检的肺组织标本,应用免疫组化方法、半定量剂检测其中Ⅰ型胶原和Ⅲ型胶原的含量结合临床治疗效果,对有助于疾病活动性判断的指标进行了筛选和进一步的评价。

It were found by comprehensive analysis, the precisive diagnosis rates of the markers from bronchoalveolar lavage fluid were much higher than that from blood, and the markers from alveolar macrophage were much higher than that from broncholaveolar lavage fluid. The precisive diagnosis rates of fibronectin secreted by alveolar macrophage, and fibronectin secreted by alveolar macrophage inhibited by cort and inhibitory rate were 96. 2%, 92. 3%, and 92. 3%, with the diagnosis markers of higher sensibitity and specificity.

综合分析发现,支气管肺灌洗液中指标的正确诊断率高于外周血,而肺泡巨噬细胞中诊断指标又优于支气管肺灌洗液,其中肺泡巨噬细胞产生的纤维结合蛋白、皮质激素抑制肺泡巨噬细胞产生纤维结合蛋白和纤维结合蛋白抑制率均为敏感性和特异性较高的诊断指标,其正确诊断率分别为96.2%、92.3%和92.3%。

September 17, 2007 — An implantable endobronchial valve has been found to significantly improve lung function measures and quality of life for patients with emphysema. The valve is designed to block air flow to a diseased region of an emphysematous lung, thereby conferring the benefits of lung volume reduction surgery without the risks of major surgery.

September 17, 2007-一项植入性支气管内瓣膜已经被证实可以显著改善肺气肿病患肺功能、以及生活品质,这个瓣膜被设计来阻断气流进入肺气肿肺的罹病部位,因此提供了肺容积减低手术的好处,却不用冒进行重大手术的风险。

Results The image displays of bronchial rupture are the following ones:atelectasis after bronchial discontinue,"downfallen lung" sign;pneumothorax or hydropneumothorax,and mediastinal emphysema or/and pneumoderma.

结果 支气管断裂的影像表现为:支气管中断后的肺不张,&坠落肺&征;气胸或液气胸;纵隔或/和皮下气肿。

Results: In treatment group, the results showed that inquination rate of segmental bronchus was zero by cultured bacteria of excretion and examed their susceptibility to antibiotics.

经纤维支气管镜,清除支气管分泌物并向感染支气管肺段内注入有效抗生素,是治疗气管切开术后肺部感染的高效、经济、适用的方法。

objective according to 14 cases of patients with post-traumatic bronchial rupture of the ct and x-ray findings.analysis of its causes,trauma type,and ct,x-ray value and the advantages and disadvantages.methods 14 cases of bronchial rupture in patients with clinical data,x-ray,ct-chip analysis and summing up.results traumatic bronchial rupture study the performance of the main image①bronchial cut-off levy;②atelectasis and pulmonary fall levy③pleural effusion,pneumatosis;④mediastinum,subcutaneous emphysema;⑤many thoracic fractures;⑥traumatic wet lung,and so on.conclusion for traumatic bronchial rupture combined with x-ray and ct examination can be clearly diagnosed early.

目的 根据14例患者外伤后支气管断裂的ct和x线表现,分析其起因、外伤类型和ct、x线应用价值及优劣势。方法对14例支气管断裂患者的临床资料、x线平片、ct片进行分析、总结。结果外伤性支气管断裂的主要影像学表现①支气管截断征;②肺不张与肺坠落征;③胸腔积液、积气;④纵隔、皮下气肿;⑤胸廓多发骨折;⑥合并创伤性湿肺等。结论对于外伤性支气管断裂结合x线摄片和ct检查是可以早期明确诊断的。

Drug intervention groups received either daily inhalation of budesonide, ipratropine or heparin respectively, starting on the 8th day or TGF-β1 monoclonal antibody(TB21)0.5 mg twice (6th and 19th day) via the tail veinous injection.

其它各药物干预组于制作模型第8 d起分别雾化吸入布地奈德(布地奈德组,12只)、溴化异丙托品(溴化异丙托品组,12只)和肝素(肝素组,6只)溶液。4周后检测小支气管平滑肌及胶原厚度,用免疫组化法及原位杂交法观察各生长因子在支气管肺内的表达,用放免法检测血清和BALF中细胞外基质成分Ⅲ型前胶原、层粘连蛋白及透明质酸。

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