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Results AQP1 is expressed at the apical and basolateral membrane of the microvascular endothelium; AQP3 was detected at basal cells of both the bronchiole epithelium and submucosal gland acinus; AQP4 is present in the basolateral membrane of columnar cells in bronchiole; while AQP5 is expressed in the apical membrane of type Ⅰ pneumocytes, and also at the apical of columnar cells of superficial epithelium and submucosal gland acinar cells.

结果本研究发现AQPs基因在羊肺中的表达分布与人相似,AQP1在肺内的毛细血管内皮细胞表达;AQP3在小支气管黏膜上皮的基底细胞的基侧膜表达,AQP4存在于小支气管黏膜上皮的柱状纤毛细胞的基侧膜;AQP5存在于Ⅰ型肺泡上皮细胞的顶质膜,存在于小支气管黏膜上皮柱状纤毛细胞,以及在气道黏膜下腺的腺细胞的顶质膜表达。

Machine of concealed source sex turns a sex pneumonic is one kind a qualitative sex that names with clinical pathology is pneumonic, COP was 1985 Epler [the pathology performance that 1] offers is pulmonary alveolus inside, fine bronchus of sex of alveolar canal, breath and eventually the independent disease that end fine bronchus has granulation organization to form inside antrum is planted, say to send a gender especially again machine of fine bronchitic companion turns out-of-the-way sex the gender is pneumonic , will nearly 20 years report gradually grow in quantity, easy infection, n/med tuberculosis, tumour, as nodal as lung disease, other a disease of qualitative sex lung promiscuous, reached my courtyard to received vivid check of treated bronchus lens lung 2008 2007 now (8 case that TBLB) wins pathology to confirm are analysed as follows.

概要: 隐源性机化性肺炎是一类以临床病理命名的间质性肺炎,COP是1985年Epler等[1]提出的病理表现为肺泡内、肺泡管、呼吸性细支气管及终末细支气管腔内有肉芽组织形成的独立病种,又称特发性闭塞性细支气管炎伴机化性肺炎,近20年来报道逐渐增多,易和肺部感染、结核、肿瘤、结节病、其他间质性肺疾病等混淆,现将我院2007年至2008年收治的支气管镜肺活检获得病理证实的8例病例分析如下。

Bronchial asthma is the most common chronic diseases in children.Asthma can not be fully explained by imbalance of Thl/Th2.With the research progress of CD4+ CD25+ Treg cell,it has been found that CD4+ CD25+ Treg cell related factors such as forkhead/winged helix transcription factor,heine oxygenase-1,transforming growth factor-β,cytotoxic T lymphocyte-associated antigen-4 are closely linked to asthmatic mechanisms.

支气管哮喘是一种儿童时期最常见的慢性疾病,单纯的Thl/Th2应答失衡并不能完全解释支气管哮喘的发生,伴随着CD4+CD25+调节性T细胞的研究进展,人们发现与CD4+CD25+Treg细胞相关的因素如叉头/翼状螺旋转录因子、血红蛋白加氧酶-1、转化生长因子β、细胞毒性T淋巴细胞相关抗原-4与支气管哮喘均有密切的联系。

Object: According to the theory of Traditional Chinese Medicine and Modern Medicine, set up the bronchial asthma models and observed the general clinical symptoms and the plasma content of ET, TXB2 and 6-keto-PGF1α in experimental guinea pigs, then, the changes of those can illuminate the mechanism of shegan mahuang syrup.

目的:通过对支气管哮喘豚鼠的实验研究,从内皮素、血栓素B_2(TXB_2)、6-酮-前列腺素F_(1α)6-keto-PGF_(1α的角度说明射干麻黄糖浆可以治疗豚鼠支气管哮喘及其治疗豚鼠支气管哮喘的机理。

Objective: To measure the variation and significance of respiratory impedance and pulmonary ventilation function in patients with bronchial asthma by impulse oscillometry before or after the bronchial provocation test, investigate the relationship between the IOS method and bronchial provocation test, and evaluate the clinical significance in bronchial asthma by IOS method.

目的:应用脉冲振荡法测定支气管哮喘患者在支气管激发试验前后的呼吸阻抗及肺通气功能参数的变化规律和临床意义,探讨IOS测定方法能否作为支气管激发试验的判断方法以及IOS测定参数在哮喘诊断中的价值。

The HRCT findings in patients with BOOP include: 1 patchy consolidation (seen in 80% of cases) or ground-glass opacity (in 60% of cases), often with a subpleural and/or peribronchial distribution; and 2 small ill-defined nodules (30-50% of cases) which may be peribronchial or peribronchiolar.

HRCT上BOOP的表现包括:1、斑片状实变(见于80%的病例)或毛玻璃样影(见于60%的病例),通常位于胸膜下和/或支气管旁;和2、边界不清的小结节(见于30~50%的病例),可于支气管旁或细支气管旁。

The results showed that:(1) In COPD group the alveolar walls were broken. The average area of alveolars was 2.46 times as big as the control group, and the average diameter was 1.42 times as compared with the control group. As the diameter of bronchioles was less than 100μm and 100~200μm respectively, the average area of smooth muscle in bronchioles increased to 3.06-fold and 2.13-fold respectively. By electron microscopic, the proportion of Clara cells of respiratory bronchioles in COPD group decreased, the Clara cells were denaturalized, the proportion of Clara cells containing low density secretory granules increased. The airway resistance was 1.84 times while the dynamic compliance was only 70.45% comparing with the control group.

结果表明:(1)光镜下,COPD组大鼠与正常对照组比较,肺泡壁破坏、肺泡腔扩大,平均肺泡面积和平均肺泡直径分别为正常对照组的2.46倍和1.42倍,在直径<100μm及直径100~200μm的小支气管,COPD组大鼠支气管平滑肌面积分别为正常对照组的3.06倍和2.13倍;电镜下可见,在呼吸性细支气管,Clara细胞占上皮细胞的比例下降,细胞变性,含低电子密度颗粒的Clara细胞比例增加;呼吸功能测定可见COPD组大鼠呼气相气道阻力是正常对照组的1.84倍、动态呼吸系统总顺应性为正常对照组的70.45%。

Results CT and HRCT had more sensitivity and specificity than X-ray chest film.There were more image manifestations in HRCT such as grand grass,net,line,nodular,honeycombing,bronchiectasis,honeycombing cyst,peribronchovascular interstitial thickening and irregularity.There were significant difference between them (P.05).These patients who were suspected IIP had better control and remission after being treated with hormone and immuno-suppressive drug.

结果 胸部CT在诊断方面比常规胸片有较大的优越性,HRCT则有更高的敏感性和特异性,HRCT表现出磨玻璃影、网状、线条、小结节、蜂窝影,支气管扩张、细支气管扩张、支气管壁和血管壁增厚及不规则等征象,12例临床疑诊为间质性肺炎的患者,经胸部HRCT诊断的12例,而胸部平片诊断的仅有2例,二者比较差异有显著性(P.05),HRCT疑诊的IIP患者,经临床激素及免疫抑制剂治疗,病情均得到控制或缓解。

objective to compare image manifestations values between high resolution computerized tomography and x-ray chest film in idiopathic interstitial pneumonia in the elderly.methods we analysed and compared image manifestations between hrct and x-ray chest film with 12 cases of clinically suspected iip in the elderly.results ct and hrct had more sensitivity and specificity than x-ray chest film.there were more image manifestations in hrct such as grand grass,net,line,nodular,honeycombing,bronchiectasis,honeycombing cyst,peribronchovascular interstitial thickening and irregularity.there were significant difference between them (p.05).these patients who were suspected iip had better control and remission after being treated with hormone and immuno-suppressive drug.conclusion it have more significant virtues in hrct to manifest iip in the elderly than x-ray chest film,and it also may manifest iip curative effect.

目的 比较高分辨断层摄影术、x线胸片检查对老年特发性间质性肺炎的诊断价值。方法对12例临床疑诊为间质性肺炎的老年患者,进行胸部hrct与胸部平片检查,并对照分析。结果胸部ct在诊断方面比常规胸片有较大的优越性,hrct则有更高的敏感性和特异性,hrct表现出磨玻璃影、网状、线条、小结节、蜂窝影,支气管扩张、细支气管扩张、支气管壁和血管壁增厚及不规则等征象,12例临床疑诊为间质性肺炎的患者,经胸部hrct诊断的12例,而胸部平片诊断的仅有2例,二者比较差异有显著性(p.05),hrct疑诊的iip患者,经临床激素及免疫抑制剂治疗,病情均得到控制或缓解。结论 hrct表现老年间质性肺炎的特点明显高于胸部平片,且hrct可以反映间质性肺炎的疗效。

Abstract] Objective To investigate the change of bronchial mucosa cilia epithelium structure on children with recurrent respiratory tract infection in acute stage and convalescence stage.Methods Choose 38 cases of patients with RRTI as study group,respiratory ciliated cells were collected by bronchial fiberscope in acute stage and convalescence stage respectively,observe the change of cilia structure by electron microscopy and compare the incidence of cilia cylindrical epithelium structure abnormality.

摘要] 目的研究反复呼吸道感染患儿急性期与恢复期支气管黏膜纤毛上皮结构的特点与变化,临床治疗的有效性提供客观依据方法选择符合儿童RRTI诊断标准的患儿38例作为研究对象,分别于急性期及恢复期在纤维支气管镜下夹取支气管黏膜组织,电镜下观察纤毛上皮结构的特点并比较纤毛异常的发病率,探讨RRTI患儿治疗后纤毛的恢复情况。

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