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Results: The numbers of Bombesin positive pulmonary cells, the lamina propria S-l00 protein, neuron-specific enolase positive nerve fibers, IgE positive cells, mast cells and IgE positive mast cells significantly increased in bronchiectasis. The changes of pulmonary endocrine cells, nerve fibers and IgE positive cells were more significantly in hyperplastic BALT areas. The S-100 and NSE were found in lymphoid tissue and BALT. A close contact was found between mast cells and the S-100 positive nerve fibers. An IgE positive outer zone was found on MC surface. Mast cells and IgE positive cells were seen in the bronchial epithelium and alveolar septa.

结果:支气管扩张症中,支气管上皮蛙皮素阳性细胞、固有膜S-100蛋白和神经特异性烯醇化酶阳性神经纤维、IgE阳性细胞、MC和IgE阳性MC均显著增多,且在支气管相关淋巴组织增生的区域上述肺内分泌细胞、神经纤维和IgE阳性细胞增多尤为显著,S-100蛋白和NSE阳性神经纤维分布於弥散淋巴组织和BALT中,MC与S-100蛋白阳性神经纤维紧密接触,MC表面有IgE阳性环状带,MC和IgE阳性细胞出现在支气管上皮间和肺泡壁。

This is the microscopic appearance of bronchiectasis.

这是支气管扩张的表现。

Objective To investigate the clinical characteristics and diagnosis of chronic obstructive pulmonary disease and bronchiectasis.

目的 探讨慢性阻塞性肺病合并支气管扩张的临床特点及诊断。

The HRCT is best diagnostic method on bronchiectasis for time being.

HRCT是支气管扩张的最佳检查方法。

Methods in the past 5 years, we have diagnosed 61 cases COPD and bronchiectasis, these patients'clinical manifestations, X-ray and computed tomography of chest, pulmonary spirometry were analysed.

回顾性分析本院5年来诊断的61例慢性阻塞性肺病合并支气管扩张的患者的临床表现、影像学特点、肺功能特点。

Objective To compare the bronchodilating effects of ipratropium bromide and theophylline in chronic obstructive pulmonary disease.

目的 比较定量雾化吸入溴化异丙托品与口服氨茶碱片对支气管扩张的作用。

Results The expression of TNF-α in HBE was activated by sputa from bronchiectatic patients and Zhikuoning Mixture might su...

结论支气管上皮细胞TNF-α表达在支气管扩张症发病中可能起到重要的作用;中药支扩宁合剂可抑制支气管上皮细胞TNF-α的表达,从而抑制支气管扩张症气道炎症反应,这可能是其疗效机理之一。

Resujts:① The distribution of lesions are mostly symmetrical, extensive, predominant in the middle and lower lung fields, and posterior areas in peripheral;② There are so many HRCT findings of lung, ILD is predominant: intralobular interstitial thickening 46 cases (100%), ground-glass opacity 41 cases (89.13%), peribronchovascular or centrilobular interstitial thickening 40 cases (86.96%), interlobular septal thickening 38 cases (82.61%), irregular linear opacity 37 cases (80.43%), small nodular opacity 34 cases (73.91%), subpleural line 27 cases (58.70%), bmnchiectasis or bronchiolectasis 19 cases (41.30%), patch opacity 18 cases (39.13%), expiratory mosaic sign 15 cases (32.61%), interface sign 14 cases (30.43%), honeycombing 12 cases (26.09%), emphysema or bulla 3 cases, cystic airspace suspected 1 case, and atelectasis suspected 1 case;③ Mediastinum and pleura: multiple small lymphonodi in mediastinum 41 cases (89.13%), pleural thickening or rough 38 cases (82.61%), esophagoectasis 11 cases (23.91%), unilateral little pleural fluid 1 case, and mediastinal emphysema 1 case.

结果:①皮肌炎肺部病变分布呈对称、广泛、偏中下、偏外后的特点;②肺部HRCT表现多样,以肺间质性改变为主:小叶内间质增厚46例(100%),磨玻璃影41例(89.13%),支气管血管束增宽或小叶核心增大40例(86.96%),小叶间隔增厚38例(82.61%),不规则纤维索条影37例(80.43%),结节影34例(73.91%),胸膜下线27例(58.70%),支气管或细支气管扩张19例(41.30%),斑片影18例(39.13%),呼气相马赛克征15例(32.61%),界面征14例(30.43%),蜂窝影12例(26.09%),肺气肿或肺大泡3例,单纯囊状气腔1例,肺不张l例;③纵隔及胸膜:纵隔小淋巴结影41例(89.13%),胸膜增厚或毛糙38例(82.61%),食管扩张11例(23.91%),单侧少量性胸腔积液1例,纵隔气肿1例。

Results CT and HRCT had more sensitivity and specificity than X-ray chest film.There were more image manifestations in HRCT such as grand grass,net,line,nodular,honeycombing,bronchiectasis,honeycombing cyst,peribronchovascular interstitial thickening and irregularity.There were significant difference between them (P.05).These patients who were suspected IIP had better control and remission after being treated with hormone and immuno-suppressive drug.

结果 胸部CT在诊断方面比常规胸片有较大的优越性,HRCT则有更高的敏感性和特异性,HRCT表现出磨玻璃影、网状、线条、小结节、蜂窝影,支气管扩张、细支气管扩张、支气管壁和血管壁增厚及不规则等征象,12例临床疑诊为间质性肺炎的患者,经胸部HRCT诊断的12例,而胸部平片诊断的仅有2例,二者比较差异有显著性(P.05),HRCT疑诊的IIP患者,经临床激素及免疫抑制剂治疗,病情均得到控制或缓解。

objective to compare image manifestations values between high resolution computerized tomography and x-ray chest film in idiopathic interstitial pneumonia in the elderly.methods we analysed and compared image manifestations between hrct and x-ray chest film with 12 cases of clinically suspected iip in the elderly.results ct and hrct had more sensitivity and specificity than x-ray chest film.there were more image manifestations in hrct such as grand grass,net,line,nodular,honeycombing,bronchiectasis,honeycombing cyst,peribronchovascular interstitial thickening and irregularity.there were significant difference between them (p.05).these patients who were suspected iip had better control and remission after being treated with hormone and immuno-suppressive drug.conclusion it have more significant virtues in hrct to manifest iip in the elderly than x-ray chest film,and it also may manifest iip curative effect.

目的 比较高分辨断层摄影术、x线胸片检查对老年特发性间质性肺炎的诊断价值。方法对12例临床疑诊为间质性肺炎的老年患者,进行胸部hrct与胸部平片检查,并对照分析。结果胸部ct在诊断方面比常规胸片有较大的优越性,hrct则有更高的敏感性和特异性,hrct表现出磨玻璃影、网状、线条、小结节、蜂窝影,支气管扩张、细支气管扩张、支气管壁和血管壁增厚及不规则等征象,12例临床疑诊为间质性肺炎的患者,经胸部hrct诊断的12例,而胸部平片诊断的仅有2例,二者比较差异有显著性(p.05),hrct疑诊的iip患者,经临床激素及免疫抑制剂治疗,病情均得到控制或缓解。结论 hrct表现老年间质性肺炎的特点明显高于胸部平片,且hrct可以反映间质性肺炎的疗效。

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