支气管哮喘

Lots of factors,such as the virus infection, the acarid and dust in the room, the blackbeetle, the tobacco smoke, the air pollution, the chemical stimulation and the like , can trigger bronchial asthma. The contamination of suspending particulates with the diameter less than 2.5 micron in the atmosphere is the main reason that makes mortality ascend,for the contamination can aggravate the hypersusceptibility which embitter more and more people .

支气管哮喘也称哮喘病，病毒感染、室尘螨与蟑螂等变应原触发因素，以及烟草烟雾、空气污染、化学刺激等均可引起发病，大气中直径不足2.5微米的悬浮微粒污染物是导致死亡率上升的因素，微粒污染会加剧人体过敏反应，全球遭受过敏之苦的人数正与日俱增。

Juvenile bronchial asthma is a severe disease which is harmful to children. It characterized of whoop , dyspnea , chest stuffiness and cough time after time. It is caused by the EOS, T-cell and so on which lead the chronic inflammation of respiratory air-way. Asthma often outbreak or aggravate at nighttime and early morning.

支气管哮喘简称哮喘，是由嗜酸性粒细胞、肥大细胞和T淋巴细胞等多种炎性细胞参与的气道慢性炎症，使易感者对各种激发因子具有气道高反应性，并可引起气道缩窄，表现为反复发作的喘息、呼吸困难、胸闷或咳嗽等症状，常在夜间和清晨发作、加剧，多数患儿可经治疗或自行缓解。

Objective To evaluate the effect of airway responsiveness on asthma and to study the causes of asthma.

目的 评价气道反应性对支气管哮喘发病的影响，探讨哮喘的病因。

The results are compared and analyzed.Results Among the 244 patients' bronchial provocation test results,160 are positive （65.57%）,77 are negative （31.56%） and 7 are suspected positive （2.87%）.The 160 positive patients are treated with glucocorticoid and bronchodilatation,and the symptoms are relieved.

结果 244例患者支气管激发试验阳性160例（65.57%），阴性77例（31.56%），可疑阳性7例（2.87%）。160例支气管激发试验阳性患者按支气管哮喘予吸入糖皮质激素及支气管舒张剂治疗，症状缓解。

The pathogenesis of asthma can be divided into three stages in immunology. The initial stage is sensibilization, which is closely associated with the activation of T cells. B7/CD28 and CD69 also play a significant role in this process. The second stage is chronic allergic inflammation. The immune dysfunction resulting from the disturbance of TH1/TH2 is a major cause of chronic allergic inflammation, and dominates asthma attack. And the third stage is airway remodeling due to chronic inflammation. Airway remodeling is one of the major causes of refractory asthma, which also contributes to the death from asthma.

哮喘的发病从免疫学角度可以分为三期：初期为致敏阶段，与T细胞激活关系密切，B7/CD28和CD69在这一过程也扮演重要角色；第二期为慢性过敏性炎症阶段，TH1/TH2失衡导致免疫功能紊乱是此阶段的主要原因，在哮喘发作过程中起主要作用；第三期为慢性炎症引起的气道结构重构阶段，是难治性支气管哮喘的重要发病和死亡原因。

The bronchial asthmatic model was established by egg protein sensibilization and longterm inhalation provocation.The rats of each treatment groups were lavaged each day from the first time of provocation to execution.After 4 weeks of treatment,the rats were killed to obtain lung tissue for dyeing of HE.A computer assisted image analysis system was used to determine the thickness change of bronchus wall and smooth muscle.The contents of MMP9 and TIMP1 in lung tissue were determined by ELISA double antibody sandwich method.

除正常组外以卵蛋白致敏并吸入激发法制备大鼠支气管哮喘模型，各治疗组均从第1次哮喘激发开始(造模第3周)至处死前每天灌胃给药，激发并给药4 w后处死大鼠，取肺组织HE染色，彩色图像分析仪测量支气管管壁厚度、平滑肌厚度，采用ELISA双抗体夹心法测定肺组织MMP9、TIMP1含量。

Abstract］objectiveto observe the effect of vagal block using ropivacaine on preventing the attack of bronchial asthma during thoracoscopy.

摘要］目的了解并发支气管哮喘的肺部病变病人胸腔镜手术中，用罗哌卡因阻滞迷走神经对预防支气管哮喘发作的效果。

Objective: To observe the expression of GATA-3 in asthmatic mice lungs and to explore the feasibility of interleukin(IL-12) blockading GATA-3 expression in treatment of bronchial asthma.

目的：观察T细胞特异转录因子GATA-3在支气管哮喘小鼠肺部的表达，探讨应用白细胞介素12(IL-12)阻断GATA-3表达治疗支气管哮喘的可能性。

Objective:To observe the expression of GATA-3in asthmatic mice lungs and to explore the feasibility of in-terleukin(IL-12)blockading GATA-3expression in treatment of bronchial asthma.

目的观察T细胞特异转录因子GATA-3在支气管哮喘小鼠肺部的表达，探讨应用白细胞介素12(IL-12)阻断GATA-3表达治疗支气管哮喘的可能性。

Objective To compare the clinical effect of combination inhalation therapy of budesonide and salbutamol and inhalation of salbutamol alone on acute asthma episode of children.

支气管哮喘是儿科常见病，其发病率逐年上升，严重危害儿童的身心健康，吸入疗法仍是目前防治支气管哮喘的首选方法。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。